Recombinant pharmaceuticals from microbial cells: a 2015 update von Sanchez-Garcia, Laura, Martín, Lucas, Mangues, Ramon, Ferrer-Miralles, Neus, Vázquez, Esther, Villaverde, Antonio

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A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models von Falgàs, Aïda, Pallarès, Victor, Unzueta, Ugutz, Céspedes, María Virtudes, Arroyo-Solera, Irene, Moreno, María José, Sierra, Jorge, Gallardo, Alberto, Mangues, María Antonia, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda

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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma von Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon

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GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases von Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon

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Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models von Céspedes, María Virtudes, PhD, Unzueta, Ugutz, PhD, Álamo, Patricia, PhD, Gallardo, Alberto, MD, PhD, Sala, Rita, Casanova, Isolda, PhD, Pavón, Miguel Angel, PhD, Mangues, María Antonia, PhD, Trías, Manuel, MD, PhD, Lopez-Pousa, Antonio, Villaverde, Antonio, PhD, Vazquez, Esther, MD, PhD, Mangues, Ramon, PhD

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CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis von Moreno, María José, Gallardo, Alberto, Novelli, Silvana, Mozos, Ana, Aragó, Marc, Pavón, Miguel Ángel, Céspedes, María Virtudes, Pallarès, Víctor, Falgàs, Aïda, Alcoceba, Miguel, Blanco, Oscar, Gonzalez-Díaz, Marcos, Sierra, Jorge, Mangues, Ramon, Casanova, Isolda

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An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination von Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A, Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

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CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival von Moreno, María José, Bosch, Rosa, Dieguez-Gonzalez, Rebeca, Novelli, Silvana, Mozos, Ana, Gallardo, Alberto, Pavón, Miguel Ángel, Céspedes, María Virtudes, Grañena, Albert, Alcoceba, Miguel, Blanco, Oscar, Gonzalez-Díaz, Marcos, Sierra, Jorge, Mangues, Ramon, Casanova, Isolda

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Ion-dependent slow protein release from in vivo disintegrating micro-granules von Álamo, Patricia, Parladé, Eloi, López-Laguna, Hèctor, Voltà-Durán, Eric, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio

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Artificial Inclusion Bodies for Clinical Development von Sánchez, Julieta M., López‐Laguna, Hèctor, Álamo, Patricia, Serna, Naroa, Sánchez‐Chardi, Alejandro, Nolan, Verónica, Cano‐Garrido, Olivia, Casanova, Isolda, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio

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T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo von Núñez, Yáiza, Garcia-León, Annabel, Falgàs, Aïda, Serna, Naroa, Sánchez-García, Laura, Garrido, Ana, Sierra, Jorge, Gallardo, Alberto, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda

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Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors von Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier

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Selective depletion of metastatic stem cells as therapy for human colorectal cancer von Céspedes, María Virtudes, Unzueta, Ugutz, Aviñó, Anna, Gallardo, Alberto, Álamo, Patricia, Sala, Rita, Sánchez‐Chardi, Alejandro, Casanova, Isolda, Mangues, María Antònia, Lopez‐Pousa, Antonio, Eritja, Ramón, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramón

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uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy von Pavón, Miguel Angel, Arroyo-Solera, Irene, Céspedes, Maria Virtudes, Casanova, Isolda, León, Xavier, Mangues, Ramón

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Protein-Based Therapeutic Killing for Cancer Therapies von Serna, Naroa, Sánchez-García, Laura, Unzueta, Ugutz, Díaz, Raquel, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio

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Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs von Céspedes, María Virtudes, Fernández, Yolanda, Unzueta, Ugutz, Mendoza, Rosa, Seras-Franzoso, Joaquin, Sánchez-Chardi, Alejando, Álamo, Patricia, Toledo-Rubio, Verónica, Ferrer-Miralles, Neus, Vázquez, Esther, Schwartz, Simó, Abasolo, Ibane, Corchero, José Luis, Mangues, Ramon, Villaverde, Antonio

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Divalent Cations: A Molecular Glue for Protein Materials von López-Laguna, Hèctor, Sánchez, Julieta, Unzueta, Ugutz, Mangues, Ramón, Vázquez, Esther, Villaverde, Antonio

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A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model von Rioja-Blanco, Elisa, Gallardo, Alberto, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon

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Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic Sites von Céspedes, María Virtudes, Espina, Carolina, García-Cabezas, Miguel Angel, Trias, Manuel, Boluda, Alicia, Gómez del Pulgar, María Teresa, Sancho, Francesc Josep, Nistal, Manuel, Lacal, Juan Carlos, Mangues, Ramon

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Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease von Medina-Gutiérrez, Esperanza, Céspedes, María Virtudes, Gallardo, Alberto, Rioja-Blanco, Elisa, Pavón, Miquel Àngel, Asensio-Puig, Laura, Farré, Lourdes, Alba-Castellón, Lorena, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon

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