Development of a Commercial Process for Odalasvir von Tran, Duc N, Zhdanko, Alexander, Barroso, Santiago, Nieste, Patrick, Rahmani, Ramdane, Holan, Jan, Hoefnagels, Roel, Reniers, Peter, Vermoortele, Frederik, Duguid, Stewart, Cazanave, Lionel, Figlus, Marek, Muir, Colin, Elliott, Alain, Zhao, Peichao, Paden, Warren, Diaz, Cristina Hernandez, Bell, Stephen J, Hashimoto, Akihiro, Phadke, Avinash, Wiles, Jason A, Vogels, Ilse, Farina, Vittorio

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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A process toward the manufacture of (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-1... von WAGSCHAL Simon Albert, CAO Duy Chi Trung, MOWER Matthew Penfield, PEREGO Luca Alessandro, BROGGINI Diego Fernando Domenico, GALLAGHER William P, WEI Carolyn S, SCHMALZBAUER Bj?rn, KOSCHKER Philipp, ZHDANKO Alexander, WISNIEWSKI Steven R, MUKHERJEE Subha, SINGH Amarjit, CHERNICHENKO Kostiantyn, TRAN Ngoc Duc, XIOURAS Christos, ORTIZ Adrian, CUNIERE Nicolas, ZHENG Bin, JAMISON Christopher Robert, SKLIAR Dimitri, EASTGATE Martin D, KOLOTUCHIN Sergei, MATCHA Kiran, LUO Helen Y, SFOUGGATAKIS Chris, LEMAIRE S?bastien Fran?ois Emmanuel, JUSSEAU Xavier Jean-Marie, BEN HA?M Cyril, REUTER Karl, RAHMANI Ramdane

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-1... von REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, MATCHA, KIRAN, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG

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Procedimiento para la fabricación de compuestos orgánicos von Duy Chi Trung CAO, Karl REUTER, Christos XIOURAS, Nicolas CUNIERE, Kostiantyn CHERNICHENKO, Dimitri SKLIAR, Ramdane RAHMANI, Björn SCHMALZBAUER, Steven R. WISNIEWSKI, Cyril BEN HAÏM, Kiran MATCHA, Matthew Penfield MOWER, Xavier Jean-Marie JUSSEAU, Amarjit SINGH, Diego Fernando Domenico BROGGINI, Martin D. EASTGATE, Helen Y. LUO, Philipp KOSCHKER, Bin ZHENG, Adrian ORTIZ, Carolyn S. WEI, Luca Alessandro PEREGO, Sébastien François Emmanuel LEMAIRE, Ngoc Duc TRAN, Christopher Robert JAMISON, Simon Albert WAGSCHAL, Chris SFOUGGATAKI, Sergei KOLOTUCHIN, William P. GALLAGHER, Subha MUKHERJEE, Alexander ZHDANKO

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PROCEDIMIENTO PARA LA FABRICACION DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}- 1-(DIFLUOROMETIL)-6-METIL-1 4,7,8,9,10-HEXAHIDRO-11,1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, MUKHERJEE, Subha, WEI, Carolyn S, SCHMALZBAUER, Bjorn, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, BEN HAIM, Cyril, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, CHERNICHENKO, Kostiantyn, GALLAGHER, William P, JUSSEAU, Xavier Jean-Marie, LEMAIRE, Sebastien François Emmanuel, ZHDANKO, Alexander

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Procedimiento para la fabricación de (6r,10s)-10-{4-[5-cloro-2-(4-cloro-1h-1,2,3-triazol-1-il)fenil]-6-oxo-1(6h)-pirimidinil}- 1-(difluorometil)-6-metil-1 4,7,8,9,10-hexahidro-11,1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander

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(6R,10S)-10-{4-[5-클로로-2-(4-클로로-1H-1,2,3-트리아졸-1-일)페닐]-6-옥소-1(6H)-피리미디닐}-1-피라졸로[4,3-B][1,7]디아자시클로테트라데신-5(6H)-온을 제조하는 방법... von SKLIAR DIMITRI, JUSSEAU XAVIER JEAN MARIE, LUO HELEN Y, PEREGO LUCA ALESSANDRO, BROGGINI DIEGO FERNANDO DOMENICO, XIOURAS CHRISTOS, RAHMANI RAMDANE, EASTGATE MARTIN D, CHERNICHENKO KOSTIANTYN, MUKHERJEE SUBHA, JAMISON CHRISTOPHER ROBERT, SFOUGGATAKIS CHRIS, WAGSCHAL SIMON ALBERT, GALLAGHER WILLIAM P, KOLOTUCHIN SERGEI, LEMAIRE SEBASTIEN FRANCOIS EMMANUEL, MATCHA KIRAN, WEI CAROLYN S, CAO DUY CHI TRUNG, REUTER KARL, ZHDANKO ALEXANDER, TRAN NGOC DUC, CUNIERE NICOLAS, SINGH AMARJIT, MOWER MATTHEW PENFIELD, WISNIEWSKI STEVEN R, KOSCHKER PHILIPP, ZHENG BIN, ORTIZ ADRIAN, BEN HAIM CYRIL, SCHMALZBAUER BJOERN

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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4 -CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1 -(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO... von WAGSCHAL Simon Albert, CAO Duy Chi Trung, LEMAIRE Sebastien François Emmanuel, MOWER Matthew Penfield, PEREGO Luca Alessandro, BROGGINI Diego Fernando Domenico, GALLAGHER William P, WEI Carolyn S, KOSCHKER Philipp, ZHDANKO Alexander, WISNIEWSKI Steven R, MUKHERJEE Subha, SINGH Amarjit, CHERNICHENKO Kostiantyn, TRAN Ngoc Duc, SCHMALZBAUER Björn, XIOURAS Christos, BEN HAÏM Cyril, ORTIZ Adrian, ZHENG Bin, CUNIERE Nicolas, JAMISON Christopher Robert, SKLIAR Dimitri, EASTGATE Martin D, KOLOTUCHIN Sergei, MATCHA Kiran, LUO Helen Y, SFOUGGATAKIS Chris, REUTER Karl, RAHMANI Ramdane, JUSSEAU Xavier Jean-marie

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PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO... von NICOLAS CUNIERE, NGOC DUC TRAN, XAVIER JEAN-MARIE JUSSEAU, HELEN Y. LUO, RAMDANE RAHMANI, SÉBASTIEN FRANÇOIS EMMANUEL LEMAIRE, CHRISTOPHER ROBERT JAMISON, CYRIL BEN HAIM, SIMON ALBERT WAGSCHAL, CAROLYN S. WEI, BJÖRN SCHMALZBAUER, AMARJIT SINGH, LUCA ALESSANDRO PEREGO, SUBHA MUKHERJEE, DIEGO FERNANDO DOMENICO BROGGINI, CHRIS SFOUGGATAKIS, BIN ZHENG, DUY CHI TRUNG CAO, PHILIPP KOSCHKER, WILLIAM P. GALLAGHER, KOSTIANTYN CHERNICHENKO, SERGEI KOLOTUCHIN, DIMITRI SKLIAR, STEVEN R. WISNIEWSKI, MARTIN D. EASTGATE, ADRIAN ORTIZ, KARL REUTER, ALEXANDER ZHDANKO, MATTHEW PENFIELD MOWER, KIRAN MATCHA, CHRISTOS XIOURAS

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PROCEDIMIENTO PARA LA FABRICACIÓN DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAHIDRO-11,15... von REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, SCHMALZBAUER, BJRN, BEN HAM, CYRIL, JAMISON, CHRISTOPHER ROBERT, MARIE - MATCHA, KIRAN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, LEMAIRE, SBASTIEN FRANOIS EMMANUEL, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, JUSSEAU, XAVIER JEAN, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG

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A process toward the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-... von REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, MATCHABA, KIRAN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG

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PROCEDIMIENTO PARA LA FABRICACIÓN DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}- 1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAHIDRO-11,1... von SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, BEN HA¿M. Cyril, SKLIAR, Dimitri, EASTGATE, Martin D, CAO, Duyt Chi Trung, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, WEI, Carolyn S, MUKHERJEE, SUBHA, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, ZHDANKO, Alexander

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The two-echelon multi-products location-routing problem with pickup and delivery: formulation and heuristic approaches von Rahmani, Younes, Ramdane Cherif-Khettaf, Wahiba, Oulamara, Ammar

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Scheduling: Agreement graph vs resource constraints von Cherif, W. Ramdane, Rahmani, Younes, Ramdane, Wahiba, Kovalyov, Mikhail, Soukhal, Ameur, Bendraouche, Mohamed, Boudhar, Mourad, Oulamara, Ammar

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A Local Search approach for the Two–Echelon Multi-products Location–Routing problem with Pickup and Delivery von Rahmani, Y., Cherif-Khettaf, W. Ramdane, Oulamara, A.

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