opsin shift and mechanism of spectral tuning in rhodopsin von Rajamani, Ramkumar, Lin, Yen-Lin, Gao, Jiali

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Balancing Kinetic and Thermodynamic Control:  the Mechanism of Carbocation Cyclization by Squalene Cyclase von Rajamani, Ramkumar, Gao, Jiali

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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor von Zheng, Barbara, D’Andrea, Stanley V, Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Yan, Hrnciar, Peter, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Yu, Fei, Sheaffer, Amy K, Knipe, Jay O, Mosure, Kathy, Rajamani, Ramkumar, Good, Andrew C, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Paruchuri, Manjula, Ng, Alicia, Gao, Qi, Rampulla, Richard A, Mathur, Arvind, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M

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Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain von Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., Macor, John E.

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Combined QM/MM study of the opsin shift in bacteriorhodopsin von Rajamani, Ramkumar, Gao, Jiali

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A two-state homology model of the hERG K + channel: application to ligand binding von Rajamani, Ramkumar, Tounge, Brett A., Li, Jian, Reynolds, Charles H.

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Implementation of an adaptive umbrella sampling method for the calculation of multidimensional potential of mean force of chemical reactions in solution von Rajamani, Ramkumar, Naidoo, Kevin J., Gao, Jiali

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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatmen... von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Inf... von Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

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Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain von Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Ditta, Jonathan, Robbins, Kevin J, Rajamani, Ramkumar, Easton, Amy, Newton, Amy, Bourin, Clotilde, Mosure, Kathleen, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Bristow, Linda J, Meanwell, Nicholas A, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn

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Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Sun, Li-Qiang, Mull, Eric, D’Andrea, Stanley, Zheng, Barbara, Hiebert, Sheldon, Gillis, Eric, Bowsher, Michael, Kandhasamy, Sarkunam, Baratam, Venkata Rao, Puttaswamy, Sunitha, Pulicharla, Nagalakshmi, Vishwakrishnan, Sureshbabu, Reddy, Subba, Trivedi, Ravi, Sinha, Sarmistha, Sivaprasad, Sankar, Rao, Abhijith, Desai, Salil, Ghosh, Kaushik, Anumula, Rushith, Kumar, Amit, Rajamani, Ramkumar, Wang, Ying-Kai, Fang, Hua, Mathur, Arvind, Rampulla, Richard, Zvyaga, Tatyana A, Mosure, Kathy, Jenkins, Susan, Falk, Paul, Tagore, Debarati M, Chen, Chaoqun, Rendunchintala, Kishore, Loy, James, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M

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Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors von Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Venables, Brian, Rajamani, Ramkumar, Robbins, Kevin J., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Herrington, James, Bristow, Linda J., Meanwell, Nicholas A., Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn

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Modeling the Protonation States of the Catalytic Aspartates in β-Secretase von Rajamani, Ramkumar, Reynolds, Charles H

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CAChe 6.1 WorkSystem Pro plus Active Site Add-On. CAChe Group, Fujitsu America, Inc., 15244 Greenbriar Parkway, Beaverton, OR 97006. http://www.cachesoftware.com/. Contact CAChe gr... von Rajamani, Ramkumar

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor von Venables, Brian L., Sin, Ny, Wang, Alan Xiangdong, Sun, Li-Qiang, Tu, Yong, Hernandez, Dennis, Sheaffer, Amy, Lee, Min, Dunaj, Cindy, Zhai, Guangzhi, Barry, Diana, Friborg, Jacques, Yu, Fei, Knipe, Jay, Sandquist, Jason, Falk, Paul, Parker, Dawn, Good, Andrew C., Rajamani, Ramkumar, McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.

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A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site von Rajamani, Ramkumar, Wu, Sophie, Rodrigo, Iyoncy, Gao, Mian, Low, Simon, Megson, Lisa, Wensel, David, Pieschl, Rick L., Post-Munson, Debra J., Watson, John, Langley, David R., Ahlijanian, Michael K., Bristow, Linda J., Herrington, James

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Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors von Wu, Yong-Jin, Venables, Brian, Guernon, Jason, Chen, Jie, Sit, Sing-Yuen, Rajamani, Ramkumar, Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Herrington, James, Bristow, Linda J., Meanwell, Nicholas A., Thompson, Lorin A., Dzierba, Carolyn

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Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors von Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Marcin, Lawrence, Higgins, Mendi, Rajamani, Ramkumar, Muckelbauer, Jodi, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A

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