Enantioselective Pictet−Spengler-Type Cyclizations of Hydroxylactams:  H-Bond Donor Catalysis by Anion Binding von Raheem, Izzat T, Thiara, Parvinder S, Peterson, Emily A, Jacobsen, Eric N

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Regio- and Enantioselective Catalytic Cyclization of Pyrroles onto N-Acyliminium Ions von Raheem, Izzat T, Thiara, Parvinder S, Jacobsen, Eric N

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Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase von Hayes, Robert P., Heo, Mee Ra, Mason, Mark, Reid, John, Burlein, Christine, Armacost, Kira A., Tellers, David M., Raheem, Izzat, Shaw, Anthony W., Murray, Edward, McKenna, Philip M., Abeywickrema, Pravien, Sharma, Sujata, Soisson, Stephen M., Klein, Daniel

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Highly Enantioselective Aza-Baylis-Hillman Reactions Catalyzed by Chiral Thiourea Derivatives von Raheem, Izzat T., Jacobsen, Eric N.

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Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates von Wu, Chengwei, Raheem, Izzat T, Nahas, Debbie D, Citron, Michael, Kim, Peter S, Montefiori, David C, Ottinger, Elizabeth A, Hepler, Robert W, Hrin, Renee, Patel, Sangita B, Soisson, Stephen M, Joyce, Joseph G

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CO Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols von Maligres, Peter E., Li, Jing, Krska, Shane W., Schreier, John D., Raheem, Izzat T.

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Catalytic Asymmetric Total Syntheses of Quinine and Quinidine von Raheem, Izzat T, Goodman, Steven N, Jacobsen, Eric N

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Sustainable chromatography (an oxymoron?) von Peterson, Emily A, Dillon, Barry, Raheem, Izzat, Richardson, Paul, Richter, Daniel, Schmidt, Rachel, Sneddon, Helen F

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The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey von Smith, Sean M., Uslaner, Jason M., Cox, Christopher D., Huszar, Sarah L., Cannon, Christopher E., Vardigan, Joshua D., Eddins, Donnie, Toolan, Dawn M., Kandebo, Monika, Yao, Lihang, Raheem, Izzat T., Schreier, John D., Breslin, Michael J., Coleman, Paul J., Renger, John J.

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Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4′-Ethynyl-2-fluoro-2′-deoxyadenosine) von Alexandre, François-René, Rahali, Rachid, Rahali, Houcine, Guillon, Sandra, Convard, Thierry, Fillgrove, Kerry, Lai, Ming-Tain, Meillon, Jean-Christophe, Xu, Min, Small, James, Dousson, Cyril B, Raheem, Izzat T

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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia von Raheem, Izzat T., Schreier, John D., Fuerst, Joy, Gantert, Liza, Hostetler, Eric D., Huszar, Sarah, Joshi, Aniket, Kandebo, Monika, Kim, Somang H., Li, Jing, Ma, Bennett, McGaughey, Georgia, Sharma, Sujata, Shipe, William D., Uslaner, Jason, Vandeveer, George H., Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.

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Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance von Nawrocki, Andrea R, Rodriguez, Carlos G, Toolan, Dawn M, Price, Olga, Henry, Melanie, Forrest, Gail, Szeto, Daphne, Keohane, Carol Ann, Pan, Yie, Smith, Karen M, Raheem, Izzat T, Cox, Christopher D, Hwa, Joyce, Renger, John J, Smith, Sean M

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Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV von Schreier, John D., Embrey, Mark W., Raheem, Izzat T., Barbe, Guillaume, Campeau, Louis-Charles, Dubost, David, McCabe Dunn, Jamie, Grobler, Jay, Hartingh, Timothy J., Hazuda, Daria J., Klein, Daniel, Miller, Michael D., Moore, Keith P., Nguyen, Natalie, Pajkovic, Natasa, Powell, David A., Rada, Vanessa, Sanders, John M., Sisko, John, Steele, Thomas G., Wai, John, Walji, Abbas, Xu, Min, Coleman, Paul J.

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Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors von Cox, Christopher D., Hostetler, Eric D., Flores, Broc A., Evelhoch, Jeffrey L., Fan, Hong, Gantert, Liza, Holahan, Marie, Eng, Waisi, Joshi, Aniket, McGaughey, Georgia, Meng, Xiangjun, Purcell, Mona, Raheem, Izzat T., Riffel, Kerry, Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J.

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Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors von Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Miller, Michael D, Moore, Keith P, Pajkovic, Natasa, Patel, Sangita, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J

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Merck’s Reaction Review Policy: An Exercise in Process Safety von Bassan, Ephraim, Ruck, Rebecca T, Dienemann, Erik, Emerson, Khateeta M, Humphrey, Guy R, Raheem, Izzat T, Tschaen, David M, Vickery, Thomas P, Wood, Harold B, Yasuda, Nobuyoshi

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Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia von Raheem, Izzat T., Breslin, Michael J., Fandozzi, Christine, Fuerst, Joy, Hill, Nicole, Huszar, Sarah, Kandebo, Monika, Kim, Somang H., Ma, Bennett, McGaughey, Georgia, Renger, John J., Schreier, John D., Sharma, Sujata, Smith, Sean, Uslaner, Jason, Yan, Youwei, Coleman, Paul J., Cox, Christopher D.

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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant von Raheem, Izzat T., Breslin, Michael J., Bruno, Joseph, Cabalu, Tamara D., Cooke, Andrew, Cox, Christopher D., Cui, Donghui, Garson, Susan, Gotter, Anthony L., Fox, Steven V., Harrell, C. Meacham, Kuduk, Scott D., Lemaire, Wei, Prueksaritanont, Thomayant, Renger, John J., Stump, Craig, Tannenbaum, Pamela L., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.

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Efficient synthesis of highly functionalized tetrahydropyridopyrimidines by a novel three-component coupling reaction von Raheem, Izzat T., Schreier, John D., Breslin, Michael J.

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Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193 von Hostetler, Eric D., Fan, Hong, Joshi, Aniket D., Zeng, Zhizhen, Eng, Waisi, Gantert, Liza, Holahan, Marie, Meng, Xianjun, Miller, Patricia, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Salinas, Cristian, Williams, Mangay, Ma, Bennett, Buist, Nicole, Smith, Sean M., Coleman, Paul J., Cox, Christopher D., Flores, Brock A., Raheem, Izzat T., Cook, Jacquelynn J., Evelhoch, Jeffrey L.

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