Structural basis for partial agonism in 5-HT3A receptors von Felt, Kevin, Stauffer, Madeleine, Salas-Estrada, Leslie, Guzzo, Peter R., Xie, Dejian, Huang, Jinkun, Filizola, Marta, Chakrapani, Sudha

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Author Correction: Structural basis for partial agonism in 5-HT3A receptors von Felt, Kevin, Stauffer, Madeleine, Salas-Estrada, Leslie, Guzzo, Peter R., Xie, Dejian, Huang, Jinkun, Filizola, Marta, Chakrapani, Sudha

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Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives von Nacro, Kassoum, Zha, Conxiang (Charles), Guzzo, Peter R., Jason Herr, R., Peace, Denise, Friedrich, Thomas D.

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CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome von Roberts, Alexander, Grafton, Gillian, Powell, Andrew D., Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J., Brady, Catherine A., Qureshi, Omar, Stamataki, Zania, Manning, David D., Moore, Nicholas A., Sargent, Bruce J., Guzzo, Peter R., Barnes, Nicholas M.

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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity von Sebhat, Iyassu K, Franklin, Christopher, Lo, Michael M.-C, Chen, David, Jewell, James P, Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Guan, Xiao-Ming, Marsh, Donald J, Kosinski, Jennifer A, Metzger, Joseph M, Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R, Henderson, Alan J, Reitman, Marc L, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S

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From preclinical to clinical development: The example of a novel treatment for obesity von Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Surman, Matthew D

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CSTI-300 (SMP-100); a Novel 5-HT 3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome von Roberts, Alexander, Grafton, Gillian, Powell, Andrew D, Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J, Brady, Catherine A, Qureshi, Omar, Stamataki, Zania, Manning, David D, Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Barnes, Nicholas M

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Bifidenone: Structure–Activity Relationship and Advanced Preclinical Candidate von Huang, Zhongping, Williams, Russell B, Martin, Steven M, Lawrence, Julie A, Norman, Vanessa L, O’Neil-Johnson, Mark, Harding, Jim, Mangette, John E, Liu, Shuang, Guzzo, Peter R, Starks, Courtney M, Eldridge, Gary R

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The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties von Guo, Cheng, Hu, Min, DeOrazio, Russell J., Usyatinsky, Alexander, Fitzpatrick, Kevin, Zhang, Zhenjun, Maeng, Jun-Ho, Kitchen, Douglas B., Tom, Susan, Luche, Michele, Khmelnitsky, Yuri, Mhyre, Andrew J., Guzzo, Peter R., Liu, Shuang

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Synthesis and Biological Evaluation of N‑((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter‑1 von Cioffi, Christopher L, Liu, Shuang, Wolf, Mark A, Guzzo, Peter R, Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J, Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N, Davis, Randall N, Sakwa, Samuel A, Gupta, Priya, Sargent, Bruce J, Moore, Nicholas A, Luche, Michele M, Carr, Grant J, Khmelnitsky, Yuri L, Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya, Mhyre, Andrew J

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Initial Process Development and Scale-Up of the Synthesis of a Triple Reuptake Inhibitor ALB 109780 von Yang, Qiang, Ulysse, Luckner G, McLaws, Mark D, Keefe, Daniel K, Haney, Brian P, Zha, Congxiang, Guzzo, Peter R, Liu, Shuang

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Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and Several Fluorinated Derivatives via [3,3]-Sigmatropic Rearrangement of O-Aryloximes von Guzzo, Peter R, Buckle, Ronald N, Chou, Ming, Dinn, Sean R, Flaugh, Michael E, Kiefer, Anton D, Ryter, Kendal T, Sampognaro, Anthony J, Tregay, Steven W, Xu, Yao-Chang

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Partial Agonism of 5‑HT3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS‑D von Moore, Nicholas A, Sargent, Bruce J, Manning, David D, Guzzo, Peter R

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The discovery of diazepinone-based 5-HT3 receptor partial agonists von Manning, David D., Guo, Cheng, Zhang, Zhenjun, Ryan, Kristen N., Naginskaya, Jennifer, Choo, Sok Hui, Masih, Liaqat, Earley, William G., Wierschke, Jonathan D., Newman, Amy S., Brady, Catherine A., Barnes, Nicholas M., Guzzo, Peter R.

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Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists von Henderson, Alan J., Guzzo, Peter R., Ghosh, Animesh, Kaur, Jagjit, Koo, Jia-Man, Nacro, Kassoum, Panduga, Shailaja, Pathak, Rashmi, Shimpukade, Bharat, Tan, Valentina, Xiang, Kai, Wierschke, Jonathan D., Isherwood, Matthew L.

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Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors von Alstermark, Christer, Amin, Kosrat, Dinn, Sean R, Elebring, Thomas, Fjellström, Ola, Fitzpatrick, Kevin, Geiss, William B, Gottfries, Johan, Guzzo, Peter R, Harding, James P, Holmén, Anders, Kothare, Mohit, Lehmann, Anders, Mattsson, Jan P, Nilsson, Karolina, Sundén, Gunnel, Swanson, Marianne, von Unge, Sverker, Woo, Alex M, Wyle, Michael J, Zheng, Xiaozhang

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Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity von Hadden, Mark, Deering, Dustin M., Henderson, Alan J., Surman, Matthew D., Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 von Cioffi, Christopher L., Wolf, Mark A., Guzzo, Peter R., Sadalapure, Kashinath, Parthasarathy, Visweswaran, Dethe, Dattatraya, Maeng, Jun-Ho, Carulli, Edmund, Loong, David T.J., Fang, Xiao, Hu, Min, Gupta, Priya, Chung, Mark, Bai, Mei, Moore, Nick, Luche, Michele, Khmelnitsky, Yuri, Love, Patrick L., Watson, Megan A., Mhyre, Andrew J., Liu, Shuang

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The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids von MANGETTE, John E, JOHNSON, Matthew R, LE, Van-Duc, SHENOY, Rajesh A, ROARK, Howard, STIER, Michael, BELLIOTTI, Thomas, CAPIRIS, Thomas, GUZZO, Peter R

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5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists von Surman, Matthew D., Freeman, Emily E., Grabowski, James F., Hadden, Mark, Henderson, Alan J., Jiang, Guowei, Jiang, Xiaowu (May), Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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