Myeloproliferative neoplasms: from origins to outcomes von Nangalia, Jyoti, Green, Anthony R.

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Population dynamics of normal human blood inferred from somatic mutations von Lee-Six, Henry, Øbro, Nina Friesgaard, Shepherd, Mairi S., Grossmann, Sebastian, Dawson, Kevin, Belmonte, Miriam, Osborne, Robert J., Huntly, Brian J. P., Martincorena, Inigo, Anderson, Elizabeth, O’Neill, Laura, Stratton, Michael R., Laurenti, Elisa, Green, Anthony R., Kent, David G., Campbell, Peter J.

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Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations von Wilson, Nicola K., Kent, David G., Buettner, Florian, Shehata, Mona, Macaulay, Iain C., Calero-Nieto, Fernando J., Sánchez Castillo, Manuel, Oedekoven, Caroline A., Diamanti, Evangelia, Schulte, Reiner, Ponting, Chris P., Voet, Thierry, Caldas, Carlos, Stingl, John, Green, Anthony R., Theis, Fabian J., Göttgens, Berthold

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Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms von Grinfeld, Jacob, Nangalia, Jyoti, Green, Anthony R

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Effect of Mutation Order on Myeloproliferative Neoplasms von Ortmann, Christina A, Kent, David G, Nangalia, Jyoti, Silber, Yvonne, Wedge, David C, Grinfeld, Jacob, Baxter, E. Joanna, Massie, Charles E, Papaemmanuil, Elli, Menon, Suraj, Godfrey, Anna L, Dimitropoulou, Danai, Guglielmelli, Paola, Bellosillo, Beatriz, Besses, Carles, Döhner, Konstanze, Harrison, Claire N, Vassiliou, George S, Vannucchi, Alessandro, Campbell, Peter J, Green, Anthony R

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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis von Kollmann, Karoline, Heller, Gerwin, Schneckenleithner, Christine, Warsch, Wolfgang, Scheicher, Ruth, Ott, Rene G., Schäfer, Markus, Fajmann, Sabine, Schlederer, Michaela, Schiefer, Ana-Iris, Reichart, Ursula, Mayerhofer, Matthias, Hoeller, Christoph, Zöchbauer-Müller, Sabine, Kerjaschki, Dontscho, Bock, Christoph, Kenner, Lukas, Hoefler, Gerald, Freissmuth, Michael, Green, Anthony R., Moriggl, Richard, Busslinger, Meinrad, Malumbres, Marcos, Sexl, Veronika

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Notch Signaling Mediates Secondary Senescence von Teo, Yee Voan, Rattanavirotkul, Nattaphong, Olova, Nelly, Salzano, Angela, Quintanilla, Andrea, Tarrats, Nuria, Kiourtis, Christos, Müller, Miryam, Green, Anthony R., Adams, Peter D., Acosta, Juan-Carlos, Bird, Thomas G., Kirschner, Kristina, Neretti, Nicola, Chandra, Tamir

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Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures von Comoglio, Federico, Park, Hyun Jung, Schoenfelder, Stefan, Barozzi, Iros, Bode, Daniel, Fraser, Peter, Green, Anthony R

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DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype von Nangalia, Jyoti, Nice, Francesca L, Wedge, David C, Godfrey, Anna L, Grinfeld, Jacob, Thakker, Clare, Massie, Charlie E, Baxter, Joanna, Sewell, David, Silber, Yvonne, Campbell, Peter J, Green, Anthony R

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing von Campbell, Peter J, Pleasance, Erin D, Stephens, Philip J, Dicks, Ed, Rance, Richard, Goodhead, Ian, Follows, George A, Green, Anthony R, Futreal, P. Andy, Stratton, Michael R

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JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia von Hobbs, Catherine M., Manning, Harriet, Bennett, Cavan, Vasquez, Louella, Severin, Sonia, Brain, Lauren, Mazharian, Alexandra, Guerrero, Jose A., Li, Juan, Soranzo, Nicole, Green, Anthony R., Watson, Steve P., Ghevaert, Cedric

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Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion von Kent, David G, Li, Juan, Tanna, Hinal, Fink, Juergen, Kirschner, Kristina, Pask, Dean C, Silber, Yvonne, Hamilton, Tina L, Sneade, Rachel, Simons, Benjamin D, Green, Anthony R

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Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm von Beer, Philip A., Delhommeau, François, LeCouédic, Jean-Pierre, Dawson, Mark A., Chen, Edwin, Bareford, David, Kušec, Rajko, McMullin, Mary Frances, Harrison, Claire N., Vannucchi, Alessandro M., Vainchenker, William, Green, Anthony R.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment von Kirschner, Kristina, Chandra, Tamir, Kiselev, Vladimir, Flores-Santa Cruz, David, Macaulay, Iain C., Park, Hyun Jun, Li, Juan, Kent, David G., Kumar, Rupa, Pask, Dean C., Hamilton, Tina L., Hemberg, Martin, Reik, Wolf, Green, Anthony R.

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Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study von Campbell, Peter J, Scott, Linda M, Buck, Georgina, Wheatley, Keith, East, Clare L, Marsden, Joanne T, Duffy, Audrey, Boyd, Elaine M, Bench, Anthony J, Scott, Mike A, Vassiliou, George S, Milligan, Donald W, Smith, Steve R, Erber, Wendy N, Bareford, David, Wilkins, Bridget S, Reilly, John T, Harrison, Claire N, Green, Anthony R

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Inactivating CUX1 mutations promote tumorigenesis von Wong, Chi C, Martincorena, Inigo, Rust, Alistair G, Rashid, Mamunur, Alifrangis, Constantine, Alexandrov, Ludmil B, Tiffen, Jessamy C, Kober, Christina, Green, Anthony R, Massie, Charles E, Nangalia, Jyoti, Lempidaki, Stella, Döhner, Hartmut, Döhner, Konstanze, Bray, Sarah J, McDermott, Ultan, Papaemmanuil, Elli, Campbell, Peter J, Adams, David J

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JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia von Li, Juan, Spensberger, Dominik, Ahn, Jong Sook, Anand, Shubha, Beer, Philip A., Ghevaert, Cedric, Chen, Edwin, Forrai, Ariel, Scott, Linda M., Ferreira, Rita, Campbell, Peter J., Watson, Steve P., Liu, Pentao, Erber, Wendy N., Huntly, Brian J.P., Ottersbach, Katrin, Green, Anthony R.

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JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease von Li, Juan, Kent, David G., Godfrey, Anna L., Manning, Harriet, Nangalia, Jyoti, Aziz, Athar, Chen, Edwin, Saeb-Parsy, Kourosh, Fink, Juergen, Sneade, Rachel, Hamilton, Tina L., Pask, Dean C., Silber, Yvonne, Zhao, Xiaodong, Ghevaert, Cedric, Liu, Pentao, Green, Anthony R.

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Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes von Wilkins, Bridget S., Erber, Wendy N., Bareford, David, Buck, Georgina, Wheatley, Keith, East, Clare L., Paul, Beverley, Harrison, Claire N., Green, Anthony R., Campbell, Peter J.

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