MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L., Bedo, Justin, McCabe, Mark J., Pajic, Marina, Croucher, David R., Rajal, Alvaro Gonzalez, Junankar, Simon R., Saunders, Darren N., Lobachevsky, Pavel, Papenfuss, Anthony T., Nessem, Danielle, Nobis, Max, Warren, Sean C., Timpson, Paul, Cowley, Mark, Vargas, Ana C., Qiu, Min R., Generali, Daniele G., Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M., Long, Georgina Y., Blay, Jean-Yves, Thomas, David M.

Volltext

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients von Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

Volltext

Crosstalk and signaling switches in mitogen-activated protein kinase cascades von Fey, Dirk, Croucher, David R, Kolch, Walter, Kholodenko, Boris N

Volltext

Revisiting the biological roles of PAI2 (SERPINB2) in cancer von Ranson, Marie, Croucher, David R, Saunders, Darren N, Lobov, Sergei

Volltext

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers von Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N

Volltext

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer von Kennedy, Sean P, Han, Jeremy Z R, Portman, Neil, Nobis, Max, Hastings, Jordan F, Murphy, Kendelle J, Latham, Sharissa L, Cadell, Antonia L, Miladinovic, Dushan, Marriott, Gabriella R, O'Donnell, Yolande E I, Shearer, Robert F, Williams, James T, Munoz, Amaya Garcia, Cox, Thomas R, Watkins, D Neil, Saunders, Darren N, Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R

Volltext

Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells von HOCHGRÄFE, Falko, LUXI ZHANG, SHEARER, Robert, NAIR, Radhika, SWARBRICK, Alexander, FARATIAN, Dana, MULLEN, Peter, HARRISON, David J, BIANKIN, Andrew V, SUTHERLAND, Robert L, RAFTERY, Mark J, DALY, Roger J, O'TOOLE, Sandra A, BROWNE, Brigid C, PINESE, Mark, PORTA CUBAS, Ana, LEHRBACH, Gillian M, CROUCHER, David R, RICKWOOD, Danny, BOULGHOURJIAN, Alice

Volltext

Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases von Trevelyan, Sarah J., Brewster, Jodi L., Burgess, Abigail E., Crowther, Jennifer M., Cadell, Antonia L., Parker, Benjamin L., Croucher, David R., Dobson, Renwick C. J., Murphy, James M., Mace, Peter D.

Volltext

A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma von Rajal, Alvaro Gonzalez, Marzec, Kamila A., McCloy, Rachael A., Nobis, Max, Chin, Venessa, Hastings, Jordan F., Lai, Kaitao, Kennerson, Marina, Hughes, William E., Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E., Watkins, D. Neil, Croucher, David R., Burgess, Andrew

Volltext

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway von CROUCHER, David R, HOCHGRÄFE, Falko, SHEARER, Robert, GALLEGO-ORTEGA, David, SAUNDERS, Darren N, SWARBRICK, Alexander, DALY, Roger J, LUXI ZHANG, LING LIU, LYONS, Ruth J, RICKWOOD, Danny, TACTACAN, Carole M, BROWNE, Brigid C, ALI, Naveid, CHAN, Howard

Volltext

A zebrafish functional genomics model to investigate the role of human A20 variants in vivo von Cultrone, Daniele, Zammit, Nathan W., Self, Eleanor, Postert, Benno, Han, Jeremy Z. R., Bailey, Jacqueline, Warren, Joanna, Croucher, David R., Kikuchi, Kazu, Bogdanovic, Ozren, Chtanova, Tatyana, Hesselson, Daniel, Grey, Shane T.

Volltext

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages von Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J

Volltext

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma von Phimmachanh, Monica, Han, Jeremy Z. R., O'Donnell, Yolande E., Latham, Sharissa L., Croucher, David R.

Volltext

The extracellular matrix as a key regulator of intracellular signalling networks von Hastings, Jordan F, Skhinas, Joanna N, Fey, Dirk, Croucher, David R, Cox, Thomas R

Volltext

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions von Freeman, Roxann, Niego, Be׳eri, R. Croucher, David, Pedersen, Lars O, Medcalf, Robert L

Volltext

The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family von Kennedy, Sean P, Hastings, Jordan F, Han, Jeremy Z R, Croucher, David R

Volltext

Nedd4 controls animal growth by regulating IGF-1 signaling von Cao, Xiao R, Lill, Nancy L, Boase, Natasha, Shi, Peijun P, Croucher, David R, Shan, Hongbo, Qu, Jing, Sweezer, Eileen M, Place, Trenton, Kirby, Patricia A, Daly, Roger J, Kumar, Sharad, Yang, Baoli

Volltext

Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover von Raftopulos, Nikki L, Washaya, Tinashe C, Niederprüm, Andreas, Egert, Antonia, Hakeem-Sanni, Mariam F, Varney, Bianca, Aishah, Atqiya, Georgieva, Mariya L, Olsson, Ellinor, Dos Santos, Diandra Z, Nassar, Zeyad D, Cochran, Blake J, Nagarajan, Shilpa R, Kakani, Meghna S, Hastings, Jordan F, Croucher, David R, Rye, Kerry-Anne, Butler, Lisa M, Grewal, Thomas, Hoy, Andrew J

Volltext

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma von Hastings, Jordan F., Rajal, Alvaro Gonzalez, Latham, Sharissa L., Han, Jeremy Z. R., McCloy, Rachael A., O'Donnell, Yolande Ei, Phimmachanh, Monica, Murphy, Alexander D., Nagrial, Adnan, Daneshvar, Dariush, Chin, Venessa, Watkins, D. Neil, Burgess, Andrew, Croucher, David R.

Volltext

Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma von Gonzalez-Rajal, Alvaro, Hastings, Jordan F., Watkins, D. Neil, Croucher, David R., Burgess, Andrew

Volltext