Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood von Quancard, Jean, Simic, Oliver, Pissot Soldermann, Carole, Aichholz, Reiner, Blatter, Markus, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Endres, Ralf, Sorge, Mickael, Kieffer, Laurence, Wagner, Trixie, Beltz, Karen, Mcsheehy, Paul, Wartmann, Markus, Régnier, Catherine H, Calzascia, Thomas, Radimerski, Thomas, Bigaud, Marc, Weiss, Andreas, Bornancin, Frédéric, Schlapbach, Achim

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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing von Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H

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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation von Bornancin, Frédéric, Renner, Florian, Touil, Ratiba, Sic, Heiko, Kolb, Yeter, Touil-Allaoui, Ismahane, Rush, James S, Smith, Paul A, Bigaud, Marc, Junker-Walker, Ursula, Burkhart, Christoph, Dawson, Janet, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, Zamurovic, Natasa, McCoy, Kathy D, Rolink, Antonius, Régnier, Catherine H, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar D, Calzascia, Thomas

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The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling von Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A., Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M., Priatel, John J., Schweigler, Patrick, Melkko, Samu, Gold, Michael R., Viner, Rosa I., Régnier, Catherine H., Turvey, Stuart E., Overall, Christopher M.

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Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation von Ginster, Stefanie, Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Renner, Florian, Lam, Stephen, Freuler, Felix, Gerrits, Bertran, Voshol, Johannes, Calzascia, Thomas, Régnier, Catherine H, Renatus, Martin, Nikolay, Rainer, Israël, Laura, Bornancin, Frédéric

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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition von Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric

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N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity von Schlapbach, Achim, Revesz, Laszlo, Pissot Soldermann, Carole, Zoller, Thomas, Régnier, Catherine H., Bornancin, Frédéric, Radimerski, Thomas, Blank, Jutta, Schuffenhauer, Ansgar, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Heng, Richard, Simic, Oliver, Endres, Ralf, Wartmann, Markus, Quancard, Jean

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Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates von Bell, Peter A., Scheuermann, Sophia, Renner, Florian, Pan, Christina L., Lu, Henry Y., Turvey, Stuart E., Bornancin, Frédéric, Régnier, Catherine H., Overall, Christopher M.

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Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimi... von Martin, Kea, Touil, Ratiba, Cvijetic, Grozdan, Israel, Laura, Kolb, Yeter, Sarret, Sophie, Valeaux, Stéphanie, Degl'Innocenti, Elena, Le Meur, Thomas, Caesar, Nadja, Bardet, Maureen, Beerli, Christian, Zerwes, Hans‐Guenter, Kovarik, Jiri, Beltz, Karen, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H., Bigaud, Marc, Junt, Tobias, Wieczorek, Grazyna, Isnardi, Isabelle, Littlewood‐Evans, Amanda, Bornancin, Frédéric, Calzascia, Thomas

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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805 von Baffert, Fabienne, Régnier, Catherine H, De Pover, Alain, Pissot-Soldermann, Carole, Tavares, Gisele A, Blasco, Francesca, Brueggen, Josef, Chène, Patrick, Drueckes, Peter, Erdmann, Dirk, Furet, Pascal, Gerspacher, Marc, Lang, Marc, Ledieu, David, Nolan, Lynda, Ruetz, Stephan, Trappe, Joerg, Vangrevelinghe, Eric, Wartmann, Markus, Wyder, Lorenza, Hofmann, Francesco, Radimerski, Thomas

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Hereditary complement C7 deficiency in nine families: Subtotal C7 deficiency revisited von Rameix‐Welti, Marie‐Anne, Régnier, Catherine H., Bienaimé, Frank, Blouin, Jacques, Schifferli, Jurg, Fridman, Wolf H., Sautès‐Fridman, Catherine, Frémeaux‐Bacchi, Veronique

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Characterization of immune functions in TRAF4-deficient mice von Cherfils-Vicini, Julien, Vingert, Benoit, Varin, Audrey, Tartour, Eric, Fridman, Wolf-Herman, Sautès-Fridman, Catherine, Régnier, Catherine H, Cremer, Isabelle

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The prevalence, characteristics and treatment of hemorrhoidal disease: results of an international web-based survey von Sheikh, Parvez, Régnier, Catherine, Goron, Fabienne, Salmat, Ghislaine

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Tumor Necrosis Factor (TNF)-Mediated Kinase Cascades: Bifurcation of Nuclear Factor-κ B and c-Jun N-Terminal Kinase (JNK/SAPK) Pathways at TNF Receptor-Associated Factor 2 von Song, Ho Yeong, Regnier, Catherine H., Kirschning, Carsten J., Goeddel, David V., Rothe, Mike

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Identification and Characterization of an IκB Kinase von Régnier, Catherine H, Song, Ho Yeong, Gao, Xiong, Goeddel, David V, Cao, Zhaodan, Rothe, Mike

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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition von Weigert, Oliver, Lane, Andrew A, Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V, Marubayashi, Sachie, Christie, Amanda L, McKeown, Michael, Paranal, Ronald M, Bradner, James E, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H, Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J, Sallan, Stephen E, Levine, Ross L, Kung, Andrew L, Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M

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Impaired Neural Tube Closure, Axial Skeleton Malformations, and Tracheal Ring Disruption in TRAF4-Deficient Mice von Régnier, Catherine H., Masson, Régis, Kedinger, Valérie, Textoris, Julien, Stoll, Isabelle, Chenard, Marie-Pierre, Dierich, Andrée, Tomasetto, Catherine, Rio, Marie-Christine

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Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent von Andraos, Rita, Qian, Zhiyan, Bonenfant, Débora, Rubert, Joëlle, Vangrevelinghe, Eric, Scheufler, Clemens, Marque, Fanny, Régnier, Catherine H, De Pover, Alain, Ryckelynck, Hugues, Bhagwat, Neha, Koppikar, Priya, Goel, Aviva, Wyder, Lorenza, Tavares, Gisele, Baffert, Fabienne, Pissot-Soldermann, Carole, Manley, Paul W, Gaul, Christoph, Voshol, Hans, Levine, Ross L, Sellers, William R, Hofmann, Francesco, Radimerski, Thomas

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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality von Shi, Tiffany, Burg, Ashley R, Caldwell, J Timothy, Roskin, Krishna M, Castro-Rojas, Cyd M, Chukwuma, P Chukwunalu, Gray, George I, Foote, Sara G, Alonso, Jesus A, Cuda, Carla M, Allman, David A, Rush, James S, Regnier, Catherine H, Wieczorek, Grazyna, Alloway, Rita R, Shields, Adele R, Baker, Brian M, Woodle, E Steve, Hildeman, David A

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The prevalence, disease characteristics and treatment of chronic venous disease: an international web-based survey von Rabe, Eberhard, Régnier, Catherine, Goron, Fabienne, Salmat, Ghislaine, Pannier, Felizitas

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