Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c von Hagiwara, Asami, Cornu, Marion, Cybulski, Nadine, Polak, Pazit, Betz, Charles, Trapani, Francesca, Terracciano, Luigi, Heim, Markus H., Rüegg, Markus A., Hall, Michael N.

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WNT7B promotes bone formation in part through mTORC1 von Chen, Jianquan, Tu, Xiaolin, Esen, Emel, Joeng, Kyu Sang, Lin, Congxin, Arbeit, Jeffrey M, Rüegg, Markus A, Hall, Michael N, Ma, Liang, Long, Fanxin

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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy von Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia von Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, Rüegg, Markus A.

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BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle von Delezie, Julien, Weihrauch, Martin, Maier, Geraldine, Tejero, Rocío, Ham, Daniel J., Gill, Jonathan F., Karrer-Cardel, Bettina, Rüegg, Markus A., Tabares, Lucía, Handschin, Christoph

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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I von Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

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Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice von Venkatesh, Aditya, Ma, Shan, Le, Yun Z, Hall, Michael N, Rüegg, Markus A, Punzo, Claudio

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Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9 von Thürkauf, Marco, Lin, Shuo, Oliveri, Filippo, Grimm, Dirk, Platt, Randall J., Rüegg, Markus A.

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice von Inoki, Ken, Mori, Hiroyuki, Wang, Junying, Suzuki, Tsukasa, Hong, SungKi, Yoshida, Sei, Blattner, Simone M, Ikenoue, Tsuneo, Rüegg, Markus A, Hall, Michael N, Kwiatkowski, David J, Rastaldi, Maria P, Huber, Tobias B, Kretzler, Matthias, Holzman, Lawrence B, Wiggins, Roger C, Guan, Kun-Liang

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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation von Ding, Xiaolei, Bloch, Wilhelm, Iden, Sandra, Rüegg, Markus A., Hall, Michael N., Leptin, Maria, Partridge, Linda, Eming, Sabine A.

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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner von Zhang, Lianjun, Tschumi, Benjamin O., Lopez-Mejia, Isabel C., Oberle, Susanne G., Meyer, Marten, Samson, Guerric, Rüegg, Markus A., Hall, Michael N., Fajas, Lluis, Zehn, Dietmar, Mach, Jean-Pierre, Donda, Alena, Romero, Pedro

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Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology von Thomanetz, Venus, Angliker, Nico, Cloëtta, Dimitri, Lustenberger, Regula M, Schweighauser, Manuel, Oliveri, Filippo, Suzuki, Noboru, Rüegg, Markus A

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Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice von SHENDE, Pankaj, PLAISANCE, Isabelle, PEDRAZZINI, Thierry, BRINK, Marijke, MORANDI, Christian, PELLIEUX, Corinne, BERTHONNECHE, Corinne, ZORZATO, Francesco, KRISHNAN, Jaya, LERCH, Rene, HALL, Michael N, RÜEGG, Markus A

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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21 von Guridi, Maitea, Tintignac, Lionel A, Lin, Shuo, Kupr, Barbara, Castets, Perrine, Rüegg, Markus A

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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle von Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

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Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype von McKee, Karen K, Crosson, Stephanie C, Meinen, Sarina, Reinhard, Judith R, Rüegg, Markus A, Yurchenco, Peter D

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice von Gödel, Markus, Hartleben, Björn, Herbach, Nadja, Liu, Shuya, Zschiedrich, Stefan, Lu, Shun, Debreczeni-Mór, Andrea, Lindenmeyer, Maja T, Rastaldi, Maria-Pia, Hartleben, Götz, Wiech, Thorsten, Fornoni, Alessia, Nelson, Robert G, Kretzler, Matthias, Wanke, Rüdiger, Pavenstädt, Hermann, Kerjaschki, Dontscho, Cohen, Clemens D, Hall, Michael N, Rüegg, Markus A, Inoki, Ken, Walz, Gerd, Huber, Tobias B

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Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology von Ruegsegger, Céline, Stucki, David M., Steiner, Silvio, Angliker, Nico, Radecke, Julika, Keller, Eva, Zuber, Benoît, Rüegg, Markus A., Saxena, Smita

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Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis von Cloëtta, Dimitri, Thomanetz, Venus, Baranek, Constanze, Lustenberger, Regula M, Lin, Shuo, Oliveri, Filippo, Atanasoski, Suzana, Rüegg, Markus A

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Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling von Blättler, Sharon M., Cunningham, John T., Verdeguer, Francisco, Chim, Helen, Haas, Wilhelm, Liu, Huifei, Romanino, Klaas, Rüegg, Markus A., Gygi, Steven P., Shi, Yang, Puigserver, Pere

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