Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study von McCarthy, James S, Prof, Lotharius, Julie, PhD, Rückle, Thomas, PhD, Chalon, Stephan, MD, Phillips, Margaret A, Prof, Elliott, Suzanne, PhD, Sekuloski, Silvana, PhD, Griffin, Paul, MD, Ng, Caroline L, PhD, Fidock, David A, Prof, Marquart, Louise, PhD, Williams, Noelle S, PhD, Gobeau, Nathalie, PhD, Bebrevska, Lidiya, PhD, Rosario, Maria, PhD, Marsh, Kennan, PhD, Möhrle, Jörg J, Dr

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A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study von McCarthy, James S, Rückle, Thomas, Djeriou, Elhadj, Cantalloube, Cathy, Ter-Minassian, Daniel, Baker, Mark, O'Rourke, Peter, Griffin, Paul, Marquart, Louise, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J

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PI3Kγ inhibition: towards an 'aspirin of the 21st century'? von Schwarz, Matthias K, Rommel, Christian, Rückle, Thomas

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BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity von Gamell, Cristina, Osses, Nelson, Bartrons, Ramon, Rückle, Thomas, Camps, Montserrat, Rosa, José Luis, Ventura, Francesc

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Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax mal... von Llanos-Cuentas, Alejandro, Casapia, Martin, Chuquiyauri, Raúl, Hinojosa, Juan-Carlos, Kerr, Nicola, Rosario, Maria, Toovey, Stephen, Arch, Robert H, Phillips, Margaret A, Rozenberg, Felix D, Bath, Jade, Ng, Caroline L, Cowell, Annie N, Winzeler, Elizabeth A, Fidock, David A, Baker, Mark, Möhrle, Jörg J, Hooft van Huijsduijnen, Rob, Gobeau, Nathalie, Araeipour, Nada, Andenmatten, Nicole, Rückle, Thomas, Duparc, Stephan

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Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study von Hartung, Hans-Peter, Derfuss, Tobias, Cree, Bruce AC, Sormani, Maria Pia, Selmaj, Krzysztof, Stutters, Jonathan, Prados, Ferran, MacManus, David, Schneble, Hans-Martin, Lambert, Estelle, Porchet, Hervé, Glanzman, Robert, Warne, David, Curtin, Francois, Kornmann, Gabrielle, Buffet, Bénédicte, Kremer, David, Küry, Patrick, Leppert, David, Rückle, Thomas, Barkhof, Frederik

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Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo von Ali, Khaled, Camps, Montserrat, Pearce, Wayne P, Ji, Hong, Rückle, Thomas, Kuehn, Nicolas, Pasquali, Christian, Chabert, Christian, Rommel, Christian, Vanhaesebroeck, Bart

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Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis von Rommel, Christian, Camps, Montserrat, Rückle, Thomas, Ji, Hong, Ardissone, Vittoria, Rintelen, Felix, Shaw, Jeffrey, Ferrandi, Chiara, Chabert, Christian, Gillieron, Corine, Françon, Bernard, Martin, Thierry, Gretener, Denise, Perrin, Dominique, Leroy, Didier, Vitte, Pierre-Alain, Hirsch, Emilio, Wymann, Matthias P, Cirillo, Rocco, Schwarz, Matthias K

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Regulation of the severity of neuroinflammation and demyelination by TLR‐ASK1‐p38 pathway von Guo, Xiaoli, Harada, Chikako, Namekata, Kazuhiko, Matsuzawa, Atsushi, Camps, Monsterrat, Ji, Hong, Swinnen, Dominique, Jorand‐Lebrun, Catherine, Muzerelle, Mathilde, Vitte, Pierre‐Alain, Rückle, Thomas, Kimura, Atsuko, Kohyama, Kuniko, Matsumoto, Yoh, Ichijo, Hidenori, Harada, Takayuki

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Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes von FOUGERAT, Anne, GAYRAL, Stéphanie, PERRET, Bertrand, BRETON-DOUILLON, Monique, WYMANN, Matthias P, LAFFARGUE, Muriel, GOURDY, Pierre, SCHAMBOURG, Alexia, RÜCKLE, Thomas, SCHWARZ, Matthias K, ROMMEL, Christian, HIRSCH, Emilio, ARNAL, Jean-Francois, SALLES, Jean-Pierre

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Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells von PIGEAU, Gary M, KOLIC, Jelena, BALL, Brandon J, HOPPA, Michael B, WANG, Ying W, RÜCKLE, Thomas, WOO, Minna, MANNING FOX, Jocelyn E, MACDONALD, Patrick E

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PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus von Carrera, Ana C, Barber, Domingo F, Bartolomé, Almira, Hernandez, Carmen, Flores, Juana M, Redondo, Clara, Fernandez-Arias, Cristina, Camps, Montserrat, Rückle, Thomas, Schwarz, Matthias K, Rodríguez, Santiago, Martinez-A, Carlos, Balomenos, Dimitrios, Rommel, Christian

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Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis von Cummings, Hannah E, Barbi, Joseph, Reville, Patrick, Oghumu, Steve, Zorko, Nicholas, Sarkar, Anasuya, Keiser, Tracy L, Lu, Bao, Rückle, Thomas, Varikuti, Sanjay, Lezama-Davila, Claudio, Wewers, Mark D, Whitacre, Caroline, Radzioch, Danuta, Rommel, Christian, Seveau, Stéphanie, Satoskar, Abhay R

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Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation von Ji, Hong, Rintelen, Felix, Waltzinger, Caroline, Bertschy Meier, Dominique, Bilancio, Antonio, Pearce, Wayne, Hirsch, Emilio, Wymann, Matthias P., Rückle, Thomas, Camps, Montserrat, Vanhaesebroeck, Bart, Okkenhaug, Klaus, Rommel, Christian

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DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection von Sulyok, Mihály, Dr, Rückle, Thomas, PhD, Roth, Alexandra, PhD, Mürbeth, Raymund E, MD, Chalon, Stephan, PhD, Kerr, Nicola, BA(Mod), Samec, Sonia Schnieper, PhD, Gobeau, Nathalie, PhD, Calle, Carlos Lamsfus, MSc, Ibáñez, Javier, MSc, Sulyok, Zita, MD, Held, Jana, PhD, Gebru, Tamirat, MSc, Granados, Patricia, MSc, Brückner, Sina, PhD, Nguetse, Christian, PhD, Mengue, Juliana, MSc, Lalremruata, Albert, MSc, Sim, Kim Lee, PhD, Hoffman, Stephen L, MD, Möhrle, Jörg J, PhD, Kremsner, Peter G, Prof, Mordmüller, Benjamin, MD

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Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate von Clark, Robert L., Edwards, Tammye L., Longo, Monica, Kinney, Joseph, Walker, Don K., Rhodes, Jon, Clode, Sally A., Rückle, Thomas, Wells, Timothy, Andenmatten, Nicole, Huber, Anna Christine

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PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells von Barbi, Joseph, Cummings, Hannah E., Lu, Bao, Oghumu, Steve, Rückle, Thomas, Rommel, Christian, Lafuse, William, Whitacre, Caroline C., Satoskar, Abhay R.

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DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum von Collins, Katharine A, Rückle, Thomas, Elliott, Suzanne, Marquart, Louise, Ballard, Emma, Chalon, Stephan, Griffin, Paul, Möhrle, Jörg J, McCarthy, James S

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A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum i... von McCarthy, James S., Rueckle, Thomas, Elliott, Suzanne L., Ballard, Emma, Collins, Katharine A., Marquart, Louise, Griffin, Paul, Chalon, Stephan, Moehrle, Jerg J.

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The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors von Williams, Roger L, Berndt, Alex, Miller, Simon, Williams, Olusegun, Le, Daniel D, Houseman, Benjamin T, Pacold, Joseph I, Gorrec, Fabrice, Hon, Wai-Ching, Ren, Pingda, Liu, Yi, Rommel, Christian, Gaillard, Pascale, Rückle, Thomas, Schwarz, Matthias K, Shokat, Kevan M, Shaw, Jeffrey P

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