Clinical implications of subclonal TP53 mutations in acute myeloid leukemia von Prochazka, Katharina T, Pregartner, Gudrun, Rücker, Frank G, Heitzer, Ellen, Pabst, Gabriel, Wölfler, Albert, Zebisch, Armin, Berghold, Andrea, Döhner, Konstanze, Sill, Heinz

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Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia von Krönke, Jan, Bullinger, Lars, Teleanu, Veronica, Tschürtz, Florian, Gaidzik, Verena I., Kühn, Michael W.M., Rücker, Frank G., Holzmann, Karlheinz, Paschka, Peter, Kapp-Schwörer, Silke, Späth, Daniela, Kindler, Thomas, Schittenhelm, Marcus, Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations von Döhner, Konstanze, Schlenk, Richard F., Habdank, Marianne, Scholl, Claudia, Rücker, Frank G., Corbacioglu, Andrea, Bullinger, Lars, Fröhling, Stefan, Döhner, Hartmut

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Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype von Rücker, Frank G, Dolnik, Anna, Blätte, Tamara J, Teleanu, Veronica, Ernst, Aurélie, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze, Bullinger, Lars

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The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements von Grasedieck, Sarah, Cabantog, Ariene, MacPhee, Liam, Im, Junbum, Ruess, Christoph, Demir, Burcu, Sperb, Nadine, Rücker, Frank G., Döhner, Konstanze, Herold, Tobias, Pollack, Jonathan R., Bullinger, Lars, Rouhi, Arefeh, Kuchenbauer, Florian

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Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia von Lal, Ridhima, Lind, Karin, Heitzer, Ellen, Ulz, Peter, Aubell, Kristina, Kashofer, Karl, Middeke, Jan M., Thiede, Christian, Schulz, Eduard, Rosenberger, Angelika, Hofer, Sybille, Feilhauer, Birgit, Rinner, Beate, Svendova, Vendula, Schimek, Michael G., Rücker, Frank G., Hoefler, Gerald, Döhner, Konstanze, Zebisch, Armin, Wölfler, Albert, Sill, Heinz

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Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing von Dolnik, Anna, Engelmann, Julia C., Scharfenberger-Schmeer, Maren, Mauch, Julian, Kelkenberg-Schade, Sabine, Haldemann, Berit, Fries, Tamara, Krönke, Jan, Kühn, Michael W.M., Paschka, Peter, Kayser, Sabine, Wolf, Stephan, Gaidzik, Verena I., Schlenk, Richard F., Rücker, Frank G., Döhner, Hartmut, Lottaz, Claudio, Döhner, Konstanze, Bullinger, Lars

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New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise von Bohl, Stephan R, Bullinger, Lars, Rücker, Frank G

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Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia von Uckelmann, Hannah J, Kim, Stephanie M, Wong, Eric M, Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y, Krivtsov, Andrei V, Rücker, Frank G, Döhner, Konstanze, McGeehan, Gerard M, Levine, Ross L, Bullinger, Lars, Vassiliou, George S, Armstrong, Scott A

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Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular Characterization von RÜCKER, Frank G, BULLINGER, Lars, RADLWIMMER, Bernhard, KESTLER, Hans A, POLLACK, Jonathan R, LICHTER, Peter, DOHNER, Konstanze, DÖHNER, Hartmut, SCHWAENEN, Carsten, LIPKA, Daniel B, WESSENDORF, Swen, FRÖHLING, Stefan, BENTZ, Martin, MILLER, Simone, SCHOLL, Claudia, SCHLENK, Richard F

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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies von Boettcher, Steffen, Miller, Peter G., Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V., Giacomelli, Andrew O., Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J., Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E., Rücker, Frank G., Flamand, Yael, Neuberg, Donna, Lindsley, R. Coleman, Jänne, Pasi A., Hahn, William C., Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A., Ebert, Benjamin L.

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Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia von Bullinger, Lars, Rücker, Frank G., Kurz, Stephan, Du, Juan, Scholl, Claudia, Sander, Sandrine, Corbacioglu, Andrea, Lottaz, Claudio, Krauter, Jürgen, Fröhling, Stefan, Ganser, Arnold, Schlenk, Richard F., Döhner, Konstanze, Pollack, Jonathan R., Döhner, Hartmut

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Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin von Schmalbrock, Laura K., Dolnik, Anna, Cocciardi, Sibylle, Sträng, Eric, Theis, Frauke, Jahn, Nikolaus, Panina, Ekaterina, Blätte, Tamara J., Herzig, Julia, Skambraks, Sabrina, Rücker, Frank G., Gaidzik, Verena I., Paschka, Peter, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Schroeder, Thomas, Lübbert, Michael, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Larson, Richard A., Ganser, Arnold, Stunnenberg, Hendrik G., Minucci, Saverio, Stone, Richard M., Bloomfield, Clara D., Döhner, Hartmut, Döhner, Konstanze, Bullinger, Lars

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Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib von Schultheiss, Markus, Rücker, Frank G., Möller, Peter, Bullinger, Lars, Barth, Thomas F. E., von Baer, Alexandra, Wittau, Mathias, Brüderlein, Silke, von Witzleben, Adrian, Mellert, Kevin, Jäger, Daniela, Marienfeld, Ralf, Böhm, Michael J., Mayer-Steinacker, Regine

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TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome von Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Kayser, Sabine, Teleanu, Veronica, Kett, Helena, Habdank, Marianne, Kugler, Carla-Maria, Holzmann, Karlheinz, Gaidzik, Verena I., Paschka, Peter, Held, Gerhard, von Lilienfeld-Toal, Marie, Lübbert, Michael, Fröhling, Stefan, Zenz, Thorsten, Krauter, Jürgen, Schlegelberger, Brigitte, Ganser, Arnold, Lichter, Peter, Döhner, Konstanze, Döhner, Hartmut

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Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair von Herzig, Julia K, Bullinger, Lars, Tasdogan, Alpaslan, Zimmermann, Philipp, Schlegel, Martin, Teleanu, Veronica, Weber, Daniela, Rücker, Frank G, Paschka, Peter, Dolnik, Anna, Schneider, Edith, Kuchenbauer, Florian, Heidel, Florian H, Buske, Christian, Döhner, Hartmut, Döhner, Konstanze, Gaidzik, Verena I

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Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial von Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

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Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group von Rücker, Frank G., Agrawal, Mridul, Corbacioglu, Andrea, Weber, Daniela, Kapp-Schwoerer, Silke, Gaidzik, Verena I., Jahn, Nikolaus, Schroeder, Thomas, Wattad, Mohammed, Lübbert, Michael, Koller, Elisabeth, Kindler, Thomas, Götze, Katharina, Ringhoffer, Mark, Westermann, Jörg, Fiedler, Walter, Horst, Heinz A., Greil, Richard, Schroers, Roland, Mayer, Karin, Heinicke, Thomas, Krauter, Jürgen, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, Döhner, Konstanze

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Functional Classification of TP53 Mutations in Acute Myeloid Leukemia von Dutta, Sayantanee, Pregartner, Gudrun, Rücker, Frank G, Heitzer, Ellen, Zebisch, Armin, Bullinger, Lars, Berghold, Andrea, Döhner, Konstanze, Sill, Heinz

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Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia von Russ, A. C., Sander, S., Luck, S. C., Lang, K. M., Bauer, M., Rucker, F. G., Kestler, H. A., Schlenk, R. F., Dohner, H., Holzmann, K., Dohner, K., Bullinger, L.

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