Phase 0 trials/ Intra-Target-Microdosing (ITM) and the lung: a review von Quinn, Tom M, Bruce, Annya M, Burt, Tal, Dhaliwal, Kevin

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Bronchiectasis Severity Is an Independent Risk Factor for Vascular Disease in a Bronchiectasis Cohort von Evans, Ieuan Edward Shepherd, MbChB, Bedi, Pallavi, MD, Quinn, Tom M., MbChB, Hill, Adam T., MD

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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics von Quinn, Tom M., Gaughan, Erin E., Bruce, Annya, Antonelli, Jean, O'Connor, Richard, Li, Feng, McNamara, Sarah, Koch, Oliver, MacKintosh, Claire, Dockrell, David, Walsh, Timothy, Blyth, Kevin G., Church, Colin, Schwarze, Jürgen, Boz, Cecilia, Valanciute, Asta, Burgess, Matthew, Emanuel, Philip, Mills, Bethany, Rinaldi, Giulia, Hardisty, Gareth, Mills, Ross, Findlay, Emily Gwyer, Jabbal, Sunny, Duncan, Andrew, Plant, Sinéad, Marshall, Adam D.L., Young, Irene, Russell, Kay, Scholefield, Emma, Nimmo, Alastair F., Nazarov, Islom B., Churchill, Grant C., McCullagh, James S.O., Ebrahimi, Kourosh H., Ferrett, Colin, Templeton, Kate, Rannard, Steve, Owen, Andrew, Moore, Anne, Finlayson, Keith, Shankar-Hari, Manu, Norrie, John, Parker, Richard A., Akram, Ahsan R., Anthony, Daniel C., Dear, James W., Hirani, Nik, Dhaliwal, Kevin

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Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi von Wadhwa, Bharti, Malhotra, Vikas, Kerai, Sukhyanti, Husain, Farah, Pandey, Nalini Bala, Saxena, Kirti N, Singh, Vinay, Quinn, Tom M, Li, Feng, Gaughan, Erin, Shankar-Hari, Manu, Mills, Bethany, Antonelli, Jean, Bruce, Annya, Finlayson, Keith, Moore, Anne, Dhaliwal, Kevin, Edwards, Christopher

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Specific in situ immuno-imaging of pulmonary-resident memory lymphocytes in human lungs von Humphries, Duncan C, O'Connor, Richard A, Stewart, Hazel L, Quinn, Tom M, Gaughan, Erin E, Mills, Beth, Williams, Gareth O S, Stone, James M, Finlayson, Keith, Chabaud-Riou, Martine, Boudet, Florence, Dhaliwal, Kevin, Pavot, Vincent

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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE) von Gaughan, Erin E, Quinn, Tom M, Mills, Andrew, Bruce, Annya M, Antonelli, Jean, MacKinnon, Alison C, Aslanis, Vassilios, Li, Feng, O'Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A, Norrie, John, Dear, James W, Akram, Ahsan R, Koch, Oliver, Templeton, Kate, Dockrell, David H, Walsh, Timothy S, Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J, Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin

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Non-cystic fibrosis bronchiectasis in the elderly: current perspectives von Quinn, Tom M, Hill, Adam T

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A Bayesian analysis of a Test and Vaccinate or Remove study to control bovine tuberculosis in badgers (Meles meles) von Arnold, Mark E., Courcier, Emily A., Stringer, Lesley A., McCormick, Carl M., Pascual-Linaza, Ana, Collins, Shane F., Trimble, Nigel A., Ford, Tom, Thompson, Suzan, Corbett, David, Menzies, Fraser D.

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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors von King, Oliver N F, Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R, Ng, Stanley S, Quinn, Amy M, Rai, Ganesha, Mott, Bryan T, Beswick, Paul, Klose, Robert J, Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D, Maloney, David J, Schofield, Christopher J, Simeonov, Anton

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A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest von Perkins, Gavin D, Ji, Chen, Deakin, Charles D, Quinn, Tom, Nolan, Jerry P, Scomparin, Charlotte, Regan, Scott, Long, John, Slowther, Anne, Pocock, Helen, Black, John J.M, Moore, Fionna, Fothergill, Rachael T, Rees, Nigel, O’Shea, Lyndsey, Docherty, Mark, Gunson, Imogen, Han, Kyee, Charlton, Karl, Finn, Judith, Petrou, Stavros, Stallard, Nigel, Gates, Simon, Lall, Ranjit

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Radiative Absorption Enhancements Due to the Mixing State of Atmospheric Black Carbon von Cappa, Christopher D., Onasch, Timothy B., Massoli, Paola, Worsnop, Douglas R., Bates, Timothy S., Cross, Eben S., Davidovits, Paul, Hakala, Jani, Hayden, Katherine L., Jobson, B. Tom, Kolesar, Katheryn R., Lack, Daniel A., Lerner, Brian M., Li, Shao-Meng, Mellon, Daniel, Nuaaman, Ibraheem, Olfert, Jason S., Petäjä, Tuukka, Quinn, Patricia K., Song, Chen, Subramanian, R., Williams, Eric J., Zaveri, Rahul A.

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Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey von Chow, Nancy A, Gade, Lalitha, Tsay, Sharon V, Forsberg, Kaitlin, Greenko, Jane A, Southwick, Karen L, Barrett, Patricia M, Kerins, Janna L, Lockhart, Shawn R, Chiller, Tom M, Litvintseva, Anastasia P, Adams, Eleanor, Barton, Kerri, Beer, Karlyn D, Bentz, Meghan L, Berkow, Elizabeth L, Black, Stephanie, Bradley, Kristy K, Brooks, Richard, Chaturvedi, Sudha, Clegg, Whitney, Cumming, Melissa, DeMaria, Alfred, Dotson, Nychie, Epson, Erin, Fernandez, Rafael, Fulton, Tara, Greeley, Rebecca, Jackson, Brendan, Kallen, Alexander, Kemble, Sarah, Klevens, Monina, Kuykendall, Randy, Le, Ngoc H, Leung, Vivian, Lutterloh, Emily, Mcateer, Jarred, Pacilli, Massimo, Peterson, Joyce, Quinn, Monica, Ross, Kathleen, Rozwadowski, Faye, Shannon, DJ, Skrobarcek, Kimberly A, Vallabhaneni, Snigdha, Welsh, Rory, Zhu, Yan

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In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity von Lynn, Geoffrey M, Laga, Richard, Darrah, Patricia A, Ishizuka, Andrew S, Balaci, Alexandra J, Dulcey, Andrés E, Pechar, Michal, Pola, Robert, Gerner, Michael Y, Yamamoto, Ayako, Buechler, Connor R, Quinn, Kylie M, Smelkinson, Margery G, Vanek, Ondrej, Cawood, Ryan, Hills, Thomas, Vasalatiy, Olga, Kastenmüller, Kathrin, Francica, Joseph R, Stutts, Lalisa, Tom, Janine K, Ryu, Keun Ah, Esser-Kahn, Aaron P, Etrych, Tomas, Fisher, Kerry D, Seymour, Leonard W, Seder, Robert A

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Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial von Perkins, Gavin D, Prof, Lall, Ranjit, PhD, Quinn, Tom, Prof, Deakin, Charles D, Prof, Cooke, Matthew W, Prof, Horton, Jessica, MSc, Lamb, Sarah E, Prof, Slowther, Anne-Marie, DPhil, Woollard, Malcolm, Prof, Carson, Andy, FRCGP, Smyth, Mike, MSc, Whitfield, Richard, BSc, Williams, Amanda, MA, Pocock, Helen, MSc, Black, John J M, FCEM, Wright, John, FCEM, Han, Kyee, FCEM, Gates, Simon, Prof

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Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates von Costa-Verdera, Helena, Collaud, Fanny, Riling, Christopher R., Sellier, Pauline, Nordin, Jayme M. L., Preston, G. Michael, Cagin, Umut, Fabregue, Julien, Barral, Simon, Moya-Nilges, Maryse, Krijnse-Locker, Jacomina, van Wittenberghe, Laetitia, Daniele, Natalie, Gjata, Bernard, Cosette, Jeremie, Abad, Catalina, Simon-Sola, Marcelo, Charles, Severine, Li, Mathew, Crosariol, Marco, Antrilli, Tom, Quinn, William J., Gross, David A., Boyer, Olivier, Anguela, Xavier M., Armour, Sean M., Colella, Pasqualina, Ronzitti, Giuseppe, Mingozzi, Federico

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Four distinct trajectories of tau deposition identified in Alzheimer’s disease von Vogel, Jacob W., Young, Alexandra L., Oxtoby, Neil P., Smith, Ruben, Ossenkoppele, Rik, Strandberg, Olof T., La Joie, Renaud, Aksman, Leon M., Grothe, Michel J., Iturria-Medina, Yasser, Pontecorvo, Michael J., Devous, Michael D., Rabinovici, Gil D., Alexander, Daniel C., Lyoo, Chul Hyoung, Evans, Alan C., Hansson, Oskar

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Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, doubl... von Tomczak, Piotr, Venugopal, Balaji, Ferguson, Thomas, Chang, Yen-Hwa, Gross-Goupil, Marine, Burgents, Joseph E, Xu, Lei, Imai, Kentaro, Choueiri, Toni K, Venugopal, Balaji, Lin, Tzu-Ping, Symeonides, Stefan N., Sawrycki, Piotr, Haas, Naomi B., Sarwar, Naveed, Thiery-Vuillemin, Antoine, Gross-Goupil, Marine, Doshi, Gurjyot, Melichar, Bohuslav, Kopyltsov, Evgeniy, Hammers, Hans-Joerg, Menezes, Juliana de Janoski, Winquist, Eric W., Hamzaj, Alketa, Karaszewska, Boguslawa, Lipatov, Oleg N., McDermott, David, Kochuparambil, Samith T., Davis, Ian D., Peltola, Katriina, Sabbatini, Roberto, Shkolnik, Michail I., McCune, Steven, Yeung, Carrie, Laguerre, Brigitte, Fomin, Eugeniy A., Zakharia, Yousef, Yorio, Jeffrey T., Yanez Ruiz, Eduardo, Kimura, Go, Nishimura, Kazuo, Masumori, Naoya, Kato, Haruaki, Sala Gonzalez, Nuria, Chiu, Kun-Yuan, Atkins, Michael B., Heath, Elisabeth, Feyerabend, Susan, Numakura, Kazuyuki, Zukov, Ruslan, Maroto Rey, Pablo Jose, Chang, Chao-Hsiang, Vengalil, Salil, Waddell, Tom S., Hauke, Ralph, Jayram, Gautam, Estay, Angela, Rubiano, Juan Andres, Anai, Satoshi, Tsunemori, Hiroyuki, Sikora-Kupis, Bozena, Gunderson, Elizabeth, Koletsky, Alan, Chen, Kevin, Agrawal, Manish, Parnis, Francis, Barbosa, Fernando Maciel, Faucher, Genevieve, Iqbal, Nayyer, Hanna, Nawar, Ibanez, Carolina, Manneh, Ray, Holeckova, Petra, Ronkainen, Hanna, Abadie-Lacourtoisie, Sophie, Goebell, Peter J., Hoefner, Thomas, Schultze-Seemann, Wolfgang, Yokomizo, Akira, Matsukawa, Yoshihisa, Murakami, Yoji, Kim, Miso, Szczylik, Cezary, Humphreys, Alison C., Kumar, Birendra, Karam, Jose Antonio, Fleming, Mark, Zarba, Juan Jose, Leiva, Viviana E., Antonio Junior, Joao Neif, Rocha, Roberto Odebrecht, Muniz, David, Brust, Leandro, Graham, Jeffrey, Borchiellini, Delphine, McDermott, Ray, Miura, Yuji, Prow, Debra M., Hashemi-Sadraei, Neda, Kendall, Stephan D.

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The Additional Disease Burden Accompanying a Delayed Diagnosis of Multiple Myeloma: Utilising a Large Real-World Evidence Base von Quinn, Sandra CM, Kelly, Lauren, Lewis, Tom

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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers von Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

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Geography is more important than host plant use for the population genetic structure of a generalist insect herbivore von Vidal, Mayra C., Quinn, Tom W., Stireman, John O., Tinghitella, Robin M., Murphy, Shannon M.

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