Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212) von Pinto, Donald J. P., Orwat, Michael J., Smith, Leon M., Quan, Mimi L., Lam, Patrick Y. S., Rossi, Karen A., Apedo, Atsu, Bozarth, Jeffrey M., Wu, Yiming, Zheng, Joanna J., Xin, Baomin, Toussaint, Nathalie, Stetsko, Paul, Gudmundsson, Olafur, Maxwell, Brad, Crain, Earl J., Wong, Pancras C., Lou, Zhen, Harper, Timothy W., Chacko, Silvi A., Myers, Joseph E., Sheriff, Steven, Zhang, Huiping, Hou, Xiaoping, Mathur, Arvind, Seiffert, Dietmar A., Wexler, Ruth R., Luettgen, Joseph M., Ewing, William R.

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Inhibition of Factor XIa as a New Approach to Anticoagulation von Schumacher, William A, Luettgen, Joseph M, Quan, Mimi L, Seiffert, Dietmar A

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Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys von Wong, Pancras C., Quan, Mimi L.

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In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa von Wong, Pancras C., Quan, Mimi L., Watson, Carol A., Crain, Earl J., Harpel, Mark R., Rendina, Alan R., Luettgen, Joseph M., Wexler, Ruth R., Schumacher, William A., Seiffert, Dietmar A.

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a... von Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R

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Factor XIa Inhibitors as New Anticoagulants von Quan, Mimi L, Pinto, Donald J. P, Smallheer, Joanne M, Ewing, William R, Rossi, Karen A, Luettgen, Joseph M, Seiffert, Dietmar A, Wexler, Ruth R

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Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors von Hu, Zilun, Sitkoff, Doree, Glunz, Peter W., Zou, Yan, Wang, Cailan, Muckelbauer, Jodi K., Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

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Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors von Hu, Zilun, Wang, Cailan, Sitkoff, Doree, Cheadle, Nathan L., Xu, Songmei, Muckelbauer, Jodi K., Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker von Corte, James R, Fang, Tianan, Osuna, Honey, Pinto, Donald J. P, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Harper, Timothy W, Bozarth, Jeffrey M, Wu, Yiming, Luettgen, Joseph M, Seiffert, Dietmar A, Decicco, Carl P, Wexler, Ruth R, Quan, Mimi L

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Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors von Quan, Mimi L, Wong, Pancras C, Wang, Cailan, Woerner, Francis, Smallheer, Joanne M, Barbera, Frank A, Bozarth, Jeffrey M, Brown, Randi L, Harpel, Mark R, Luettgen, Joseph M, Morin, Paul E, Peterson, Tara, Ramamurthy, Vidhyashankar, Rendina, Alan R, Rossi, Karen A, Watson, Carol A, Wei, Anzhi, Zhang, Ge, Seiffert, Dietmar, Wexler, Ruth R

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Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors von Hu, Zilun, Wang, Cailan, Han, Wei, Rossi, Karen A., Bozarth, Jeffrey M., Wu, Yiming, Sheriff, Steven, Myers, Joseph E., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.

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Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies von Hu, Zilun, Wang, Cailan, Glunz, Peter W., Li, Julia, Cheadle, Nathan L., Chen, Alice Y., Chen, Xue-Qing, Myers, Joseph E., Guarino, Victor R., Rose, Anne, Sack, John S., Sitkoff, Doree, Taylor, David S., Xu, Songmei, Yan, Chunhong, Zhang, Hongwei, Zhang, Lisa, Hennan, James, Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

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Macrocyclic factor XIa inhibitors von Wang, Cailan, Corte, James R., Rossi, Karen A., Bozarth, Jeffrey M., Wu, Yiming, Sheriff, Steven, Myers, Joseph E., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.

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Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity von Hangeland, Jon J, Friends, Todd J, Rossi, Karen A, Smallheer, Joanne M, Wang, Cailan, Sun, Zhong, Corte, James R, Fang, Tianan, Wong, Pancras C, Rendina, Alan R, Barbera, Frank A, Bozarth, Jeffrey M, Luettgen, Joseph M, Watson, Carol A, Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E, Bisacchi, Gregory S, Subramaniam, Srinath, Arunachalam, Piramanayagam, Mathur, Arvind, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L

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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency von Corte, James R., Yang, Wu, Fang, Tianan, Wang, Yufeng, Osuna, Honey, Lai, Amy, Ewing, William R., Rossi, Karen A., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Zheng, Joanna J., Harper, Timothy W., Bozarth, Jeffrey M., Wu, Yiming, Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R., Lam, Patrick Y.S.

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Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors von Varnes, Jeffrey G., Wacker, Dean A., Jacobson, Irina C., Quan, Mimi L., Ellis, Christopher D., Rossi, Karen A., He, Ming Y., Luettgen, Joseph M., Knabb, Robert M., Bai, Steven, He, Kan, Lam, Patrick Y.S., Wexler, Ruth R.

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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group von Corte, James R., Fang, Tianan, Pinto, Donald J.P., Orwat, Michael J., Rendina, Alan R., Luettgen, Joseph M., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Myers, Joseph E., Sheriff, Steven, Narayanan, Rangaraj, Harper, Timothy W., Zheng, Joanna J., Li, Yi-Xin, Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.

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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties von Pinto, Donald J.P., Smallheer, Joanne M., Corte, James R., Austin, Erin J.D., Wang, Cailan, Fang, Tianan, Smith, Leon M., Rossi, Karen A., Rendina, Alan R., Bozarth, Jeffrey M., Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Sheriff, Steven, Myers, Joseph E., Morin, Paul E., Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R.

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Novel phenylalanine derived diamides as Factor XIa inhibitors von Smith, Leon M., Orwat, Michael J., Hu, Zilun, Han, Wei, Wang, Cailan, Rossi, Karen A., Gilligan, Paul J., Pabbisetty, Kumar B., Osuna, Honey, Corte, James R., Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., Narayanan, Ranga, Harper, Timothy W., Bozarth, Jeffrey M., Crain, Earl J., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Xin, Baomin, Zheng, Joanna, Seiffert, Dietmar A., Quan, Mimi L., Lam, Patrick Y.S., Wexler, Ruth R., Pinto, Donald J.P.

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Pyridine and pyridinone-based factor XIa inhibitors von Corte, James R., Fang, Tianan, Hangeland, Jon J., Friends, Todd J., Rendina, Alan R., Luettgen, Joseph M., Bozarth, Jeffrey M., Barbera, Frank A., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.

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