Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models von Nessler, Ian, Khera, Eshita, Vance, Steven, Kopp, Anna, Qiu, Qifeng, Keating, Thomas A., Abu-Yousif, Adnan O., Sandal, Thomas, Legg, James, Thompson, Lorraine, Goodwin, Normann, Thurber, Greg M.

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs) von Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J

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The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models von Hicks, Stuart W, Tarantelli, Chiara, Wilhem, Alan, Gaudio, Eugenio, Li, Min, Arribas, Alberto J, Spriano, Filippo, Bordone, Roberta, Cascione, Luciano, Lai, Katharine C, Qiu, Qifeng, Taborelli, Monica, Rossi, Davide, Stussi, Georg, Zucca, Emanuele, Stathis, Anastasios, Sloss, Callum M, Bertoni, Francesco

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Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair von Christman, Michael F, Bird, Alexander W, Yu, David Y, Pray-Grant, Marilyn G, Qiu, Qifeng, Harmon, Kirsty E, Megee, Paul C, Grant, Patrick A, Smith, M. Mitchell

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Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates von Li, Wei, Veale, Karen H, Qiu, Qifeng, Sinkevicius, Kerstin W, Maloney, Erin K, Costoplus, Juliet A, Lau, Janet, Evans, Helen L, Setiady, Yulius, Ab, Olga, Abbott, Stephen M, Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A, Chari, Ravi V. J, Widdison, Wayne C

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Catalytic-Site Mutations in the MYST Family Histone Acetyltransferase Esa1 von Decker, Peter V, Yu, David Y, Iizuka, Masayoshi, Qiu, Qifeng, Smith, M. Mitchell

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Effects of Drug–Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody–Maytansinoid Conjugates von Sun, Xiuxia, Ponte, Jose F, Yoder, Nicholas C, Laleau, Rassol, Coccia, Jennifer, Lanieri, Leanne, Qiu, Qifeng, Wu, Rui, Hong, Erica, Bogalhas, Megan, Wang, Lintao, Dong, Ling, Setiady, Yulius, Maloney, Erin K, Ab, Olga, Zhang, Xiaoyan, Pinkas, Jan, Keating, Thomas A, Chari, Ravi, Erickson, Hans K, Lambert, John M

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Asphalt Pavement Performance Evaluation Based on SOM Neural Network von Qiu, Qi Feng, Hu, Man Jiang, Ge, Ru Hai, Jin, Qiao

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Abstract 753: Development of an in vivo model system to assess the interplay between the various drivers of antibody-drug conjugate (ADC) activity von Lanieri, Leanne, Boule, Steven, Dong, Ling, Drake, Tara, Laleau, Rassol, Lee, Jenny, Liu, Fenghua, Qiu, Qifeng, Kohli, Neeraj, Ponte, Jose, Setiady, Yulius, Gregory, Richard

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Abstract 2890: IMGN151 - A next generation folate receptor alpha targeting antibody drug conjugate active against tumors with low, medium and high receptor expression von Ab, Olga, Bartle, Laura M., Lanieri, Leanne, Ponte, Jose F., Qiu, Qifeng, Sikka, Surina, Costoplus, Juliet A., Deats, Wayne, Yoder, Nicholas C., Widdison, Wayne C., Mucciarone, Katherine, Selvitelli, Kate, Chen, Ying, Kohli, Neeraj, Chittenden, Thomas, Gregory, Richard, Setiady, Yulius, Westin, Eric H.

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Abstract 2186: Peptide-cleavable maytansinoid (ADCs) induce high bystander killing leading to improved anti-tumor activity in vivo von Widdison, Wayne C., Costoplus, Juliet A., Ponte, Jose F., Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Wu, Rui, Qiu, Qifeng, Kovtun, Yelena, Chari, Ravi V.

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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells von Singh, Rajeeva, Setiady, Yulius Y, Ponte, Jose, Kovtun, Yelena V, Lai, Katharine C, Hong, E Erica, Fishkin, Nathan, Dong, Ling, Jones, Gregory E, Coccia, Jennifer A, Lanieri, Leanne, Veale, Karen, Costoplus, Juliet A, Skaletskaya, Anna, Gabriel, Rabih, Salomon, Paulin, Wu, Rui, Qiu, Qifeng, Erickson, Hans K, Lambert, John M, Chari, Ravi V J, Widdison, Wayne C

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Abstract 215: Generation of site-specific DARPin® drug conjugates using EGFR as a model system von Laviolette, Laura A., Guidi, Cynthia J., Reichen, Christian, Qiu, Qifeng, Harris, Luke, Schildknecht, Patricia, Fischer, Stefanie, Arany, Zita, Hospodarsch, Tanja, Skaletskaya, Anna, Fuller, Megan, Abbott, Stephen, McCarthy, Rebecca, Lee, Jenny, Francisco, Katherine, Sinkevicius, Kerstin, Adams, Sharlene, Espelin, Christopher, Reid, Emily, Li, Wei, Marashio, Carla, Donahue, Kerry, Hicks, Stuart, Snell, Dan

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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing von Widdison, Wayne C, Ponte, Jose F, Coccia, Jennifer A, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Hong, E. Erica, Wu, Rui, Qiu, Qifeng, Singh, Rajeeva, Salomon, Paulin, Fishkin, Nathan, Harris, Luke, Maloney, Erin K, Kovtun, Yelena, Veale, Karen, Wilhelm, Sharon D, Audette, Charlene A, Costoplus, Juliet A, Chari, Ravi V. J

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Abstract 5325: A c-Kit targeting antibody-drug conjugate is efficiently metabolized and activated inside cancer cell lines and xenograft tumors von Hong, Erica, Qiu, Qifeng, Wu, Rui, Wilhelm, Alan, Whiteman, Kathleen, Pinkas, Jan, Erickson, Hans, Abrams, Tinya, Schleyer, Siew

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Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae von Baker, Stephen P, Qiu, Qifeng, Hunt, Donald F, Shabanowitz, Jeffrey, Phillips, Jennifer, Grant, Patrick A, Anderson, Scott, Smith, M. Mitchell, Yates, John R

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Abstract 2651: A novel CD19 targeting antibody-drug conjugate, huB4-DGN462, shows promising in vitro and in vivo activity in CD19-positive lymphoma models von Gaudio, Eugenio, Tarantelli, Chiara, Arribas, Alberto J., Bordone, Roberta Pittau, Rinaldi, Andrea, Stussi, Georg, Zucca, Emanuele, Rossi, Davide, Stathis, Anastasios, Li, Min, Wilhem, Alan, Lai, Kate, Qiu, Qifeng, Hicks, Stuart, Sloss, Callum, Bertoni, Francesco

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Abstract 53: Antibody-drug conjugates (ADCs) of peptide-linked Indolino-Benzodiazepine (IGN) DNA-alkylator provides improved anti-tumor activity over that of a crosslinker von Miller, Michael L., Shizuka, Manami, Ponte, Jose F., Lanieri, Leanne, Vitharana, Dilrukshi, Qiu, Qifeng, Reid, Emily E., Archer, Katie E., Wu, Rui, Maloney, Erin K., Ab, Olga, Pinkas, Jan, Chari, Ravi V.

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Abstract 71: Bystander activity and in vivo efficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker von Qiu, Qifeng, Wu, Rui, Lanieri, Leanne, Maloney, Erin, Skaletskaya, Anna, Jin, Shan, Wang, Lintao, Ab, Olga, Ponte, Joe, Setiady, Yulius, Widdison, Wayne, Keating, Thomas, Chari, Ravi, Gregory, Richard, Hong, Erica

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Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing von Costoplus, Juliet A, Veale, Karen H, Qiu, Qifeng, Ponte, Jose F, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M, Salomon, Paulin, Wu, Rui, Maloney, Erin K, Kovtun, Yelena V, Ab, Olga, Lai, Kate, Chari, Ravi V. J, Widdison, Wayne C

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