Hypoxia and transforming growth factor‐beta1 pathway activation promote Chinese Hamster Ovary cell aggregation von Qian, Yueming, Rehmann, Matthew S., Qian, Nan‐Xin, He, Aiqing, Borys, Michael C., Kayne, Paul S., Li, Zheng Jian

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Early identification of unusually clustered mutations and root causes in therapeutic antibody development von Qian, Yueming, Chen, Zhiqiang, Huang, Xin, Wang, Xuning, Xu, Xuankuo, Kirov, Stefan, Ludwig, Richard, Qian, Nan‐Xin, Ravi, Kandasamy, Tao, Li, Borys, Michael C., Li, Zheng Jian

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Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines von Tian, Jun, He, Qin, Oliveira, Christopher, Qian, Yueming, Egan, Susan, Xu, Jianlin, Qian, Nan‐Xin, Langsdorf, Erik, Warrack, Bethanne, Aranibar, Nelly, Reily, Michael, Borys, Michael, Li, Zheng Jian

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Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells von Qian, Yueming, Khattak, Sarwat F., Xing, Zizhuo, He, Aiqing, Kayne, Paul S., Qian, Nan-Xin, Pan, Shih-Hsie, Li, Zheng Jian

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Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses von Kremer, Kimberly N, Clift, Ian C, Miamen, Alexander G, Bamidele, Adebowale O, Qian, Nan-Xin, Humphreys, Troy D, Hedin, Karen E

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Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks von Qian, Yueming, Xing, Zizhuo, Lee, Sherry, Mackin, Nancy A., He, Aiqing, Kayne, Paul S., He, Qin, Qian, Nan-Xin, Li, Zheng Jian

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Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning von He, Qin, Rehmann, Matthew S, Tian, Jun, Xu, Jianlin, Sabino, Luzmary, Vandermark, Erik, Basson, Ziev, Po, Iris, Bierilo, Kathleen, Tremml, Gabi, Rizzi, Giovanni, Langsdorf, Erik F, Qian, Nan-Xin, Borys, Michael C, Khetan, Anurag, Li, Zheng-Jian

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Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media von Xu, Jianlin, Rehmann, Matthew S, Xu, Xuankuo, Huang, Chao, Tian, Jun, Qian, Nan-Xin, Li, Zheng Jian

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Brown drug substance color investigation in cell culture manufacturing using chemically defined media: A case study von Xu, Jianlin, Jin, Mi, Song, Hangtian, Huang, Chao, Xu, Xuankuo, Tian, Jun, Qian, Nan-Xin, Steger, Kirby, Lewen, Nancy S., Tao, Li, Li, Zheng Jian

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LongR3 enhances Fc-fusion protein N-linked glycosylation while improving protein productivity in an industrial CHO cell line von Qian, Yueming, Lewis, Amanda M., Sidnam, Sarah M., Bergeron, Alison, Abu-Absi, Nicholas R., Vaidyanathan, Nisha, Deresienski, Adam, Qian, Nan-Xin, Borys, Michael C., Li, Zheng Jian

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Mitogen-Activated Protein Kinase Activation Resulting from Selective Oncogene Expression in NIH 3T3 and Rat 1a Cells von Gallego, Carme, Gupta, Sunil K., Heasley, Lynn E., Qian, Nan-Xin, Johnson, Gary L.

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Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal... von Kremer, Kimberly N, Humphreys, Troy D, Kumar, Ashok, Qian, Nan-Xin, Hedin, Karen E

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Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C von NEMENOFF, R. A, WINITZ, S, NAN-XIN QIAN, VAN PUTTEN, V, JOHNSON, G. L, HEASLEY, L. E

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How does the G protein, Gi2, transduce mitogenic signals? von Johnson, Gary L., Gardner, Anne M., Lange-Carter, Carol, Qian, Nan-Xin, Russell, Marijane, Winitz, Sim

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Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase von WINITZ, S, RUSSELL, M, NAN-XIN QIAN, GARDNER, A, DWYER, L, JOHNSON, G. L

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Evidence for Coordinate Regulation of the A System for Amino Acid Transport and the mRNA for the α1Subunit of the Na+, K+-ATPase Gene in Chinese Hamster Ovary Cells von Qian, Nan-Xin, Pastor-Anglada, Marcal, Englesberg, Ellis

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Epitope-tagged Gq alpha subunits: expression of GTPase-deficient alpha subunits persistently stimulates phosphatidylinositol-specific phospholipase C but not mitogen-activated prot... von NAN-XIN QIAN, WINITZ, S, JOHNSON, G. L

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Expression of GTPase-deficient Gα16 inhibits Swiss 3T3 cell growth von NAN-XIN QIAN, RUSSEL, M, BUHL, A. M, JOHNSON, G. L

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Stromal Cell-Derived Factor-1 Signaling via the CXCR4-TCR Heterodimer Requires Phospholipase C- beta 3 and Phospholipase C- gamma 1 for Distinct Cellular Responses von Kremer, Kimberly N, Clift, Ian C, Miamen, Alexander G, Bamidele, Adebowale O, Qian, Nan-Xin, Humphreys, Troy D, Hedin, Karen E

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Acetylcholine muscarinic receptor regulation of the Ras/Raf/Map kinase pathway von Qian, Nan-Xin, Russell, Marijane, Johnson, Gary L.

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