Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance von Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response von Quanz, Maria, Chassoux, Danielle, Berthault, Nathalie, Agrario, Céline, Sun, Jian-Sheng, Dutreix, Marie

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A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma von Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie

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DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation von Kotula, Ewa, Faigle, Wolfgang, Berthault, Nathalie, Dingli, Florent, Loew, Damarys, Sun, Jian-Sheng, Dutreix, Marie, Quanz, Maria

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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A von Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot

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Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy von QUANZ, Maria, BERTHAULT, Nathalie, COSSET, Jean-Marc, LARUE, Lionel, SUN, Jian-Sheng, DUTREIX, Marie, ROULIN, Christophe, ROY, Maryline, HERBETTE, Aurélie, AGRARIO, Celine, ALBERTI, Christophe, JOSSERAND, Véronique, COLL, Jean-Luc, SASTRE-GARAU, Xavier

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Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models von Quanz, Maria, Hagemann, Urs B, Zitzmann-Kolbe, Sabine, Stelte-Ludwig, Beatrix, Golfier, Sven, Elbi, Cem, Mumberg, Dominik, Ziegelbauer, Karl, Schatz, Christoph A

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Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci von Quanz, Maria, Herbette, Aurélie, Sayarath, Mano, de Koning, Leanne, Dubois, Thierry, Sun, Jian-Sheng, Dutreix, Marie

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Kinesin KIFC1 actively transports bare double-stranded DNA von Farina, Francesca, Pierobon, Paolo, Delevoye, Cédric, Monnet, Jordan, Dingli, Florent, Loew, Damarys, Quanz, Maria, Dutreix, Marie, Cappello, Giovanni

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Abstract 1049: Pharmacological characterization of a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with robust in vivo efficacy and increased therapeutic in... von Quanz, Maria, Merz, Claudia, Bernthaler, Andreas, Kaulfuss, Stefan, Richter, Anja, Bauser, Marcus, Haegebarth, Andrea

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Abstract 1780: Anetumab ravtansine has single-agent activity in mesothelin-expressing human ovarian cancer models and potentiates the activity of chemotherapeutics and targeted age... von Schatz, Christoph A., Quanz, Maria, Hagemann, Urs B., Zitzmann-Kolbe, Sabine, Stelte-Ludwig, Beatrix, Golfier, Sven, Kopitz, Charlotte, Elbi, Cem, Ziegelbauer, Karl, Mumberg, Dominik

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Inhibition of DNA damage repair by artificial activation of PARP with siDNA von Croset, Amelie, Cordelières, Fabrice P, Berthault, Nathalie, Buhler, Cyril, Sun, Jian-Sheng, Quanz, Maria, Dutreix, Marie

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Kinesin KIFC1 Actively Transports Double-Stranded DNA in Eukaryotic Cells von Farina, Francesca, Delevoye, Cédric, Dutreix, Marie, Quanz, Maria, Cappello, Giovanni

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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications von Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

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Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target von Ellermann, Manuel, Giese, Anja, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Rahm, Fredrik, Viklund, Jenny, Andersson, Martin, Ginman, Tobias, Forsblom, Rickard, Lindström, Johan, Trésaugues, Lionel, Gorjanacz, Matyas

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Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 von Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

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Abstract 1164: Metabolic responses in cancer cells with differential susceptibility to GLUT1 inhibition von Gruenewald, Sylvia, Rennefahrt, Ulrike, Maldonado, Sandra G., Walter, Alexander, Petrul, Heike, Héroult, Mélanie, Heisler, Iring, Quanz, Maria, Steigemann, Patrick, Buchmann, Bernd, Haegebarth, Andrea

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A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma1 von Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie

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Abstract 1442: Effects of selective and broad glucose transporter (GLUT) inhibition on glucose distribution in tumor bearing mice von Heroult, Melanie, Steinke, Wolfram, Frisk, Anna-Lena, Borkowski, Sandra, Meyer, Kirstin, Petrul, Heike, Heisler, Iring, Quanz, Maria, Neuhaus, Roland, Buchmann, Bernd, Mueller, Thomas, Bauser, Marcus, Haegebarth, Andrea, Brands, Michael, Ziegelbauer, Karl

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