The Mechanistic Impact of N-Glycosylation on Stability, Pharmacokinetics, and Immunogenicity of Therapeutic Proteins von Zhou, Qun, Qiu, Huawei

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Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life von Mackness, Brian C, Jaworski, Julie A, Boudanova, Ekaterina, Park, Anna, Valente, Delphine, Mauriac, Christine, Pasquier, Olivier, Schmidt, Thorsten, Kabiri, Mostafa, Kandira, Abdullah, Radošević, Katarina, Qiu, Huawei

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Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting... von Qiu, Yu, Stegalkina, Svetlana, Zhang, Jianxin, Boudanova, Ekaterina, Park, Anna, Zhou, Yanfeng, Prabakaran, Ponraj, Pougatcheva, Svetlana, Ustyugova, Irina, Vogel, Thorsten U., Mundle, Sophia T., Oomen, Ray, Delagrave, Simon, Ross, Ted M., Kleanthous, Harry, Qiu, Huawei

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Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease von Zhou, Yan-Feng, Metcalf, Matthew C., Garman, Scott C., Edmunds, Tim, Qiu, Huawei, Wei, Ronnie R.

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Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function von Zhou, Qun, Shankara, Srinivas, Roy, Andre, Qiu, Huawei, Estes, Scott, McVie-Wylie, Alison, Culm-Merdek, Kerry, Park, Anna, Pan, Clark, Edmunds, Tim

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Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues von Zhou, Qun, Kyazike, Josephine, Boudanova, Ekaterina, Drzyzga, Michael, Honey, Denise, Cost, Robert, Hou, Lihui, Duffieux, Francis, Brun, Marie-Priscille, Park, Anna, Qiu, Huawei

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Engineering an anti-CD52 antibody for enhanced deamidation stability von Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q, Sendak, Rebecca

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Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models von Valente, Delphine, Mauriac, Christine, Schmidt, Thorsten, Focken, Ingo, Beninga, Jochen, Mackness, Brian, Qiu, Huawei, Vicat, Pascale, Kandira, Abdullah, Radosevic, Katarina, Rao, Srini, Darbyshire, John, Kabiri, Mostafa

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Engineered Fc-glycosylation switch to eliminate antibody effector function von Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei

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XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer von Jenkins, Kurt A, Park, Miso, Pederzoli-Ribeil, Magali, Eskiocak, Ugur, Johnson, Parker, Guzman, Wilson, McLaughlin, Megan, Moore-Lai, Deborah, O’Toole, Caitlin, Liu, Zhen, Nicholson, Benjamin, Flesch, Veronica, Qiu, Huawei, Clackson, Tim, O’Hagan, Ronan C, Rodeck, Ulrich, Karow, Margaret, O’Neil, Jennifer, Williams, John C

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Carbohydrate-Mediated Polyethylene Glycol Conjugation of TSH Improves Its Pharmacological Properties von Park, Anna, Honey, Denise M, Hou, Lihui, Bird, Julie J, Zarazinski, Christine, Searles, Michelle, Braithwaite, Christian, Kingsbury, Jonathan S, Kyazike, Josephine, Culm-Merdek, Kerry, Greene, Ben, Stefano, James E, Qiu, Huawei, McPherson, John M, Pan, Clark Q

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Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease von Van Patten, Scott M, Hughes, Heather, Huff, Michael R, Piepenhagen, Peter A, Waire, James, Qiu, Huawei, Ganesa, Chandrashekar, Reczek, David, Ward, Paul V, Kutzko, Joseph P, Edmunds, Tim

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Effect of exemestane endocrine therapy for hormone-receptor-positive breast cancer patients with varying levels of ctDNA von Chen, Yanning, Huawei, Qiu

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719 XTX301, a protein-engineered IL-12, exhibits tumor-selective activity in mice without peripheral toxicities and is well tolerated in non-human primates von Patel, Ekta, Malkova, Natalia, Vu, Sallyann, O'Donnell, Rebekah, Fanny, Manoussa, Guzman, Wilson, Johnson, Parker, McLaughlin, Megan, Yerov, Oleg, Jenkins, Kurt, Madala, Hanumantha Rao, O'Toole, Caitlin, Pederzoli-Ribeil, Magali, Chen, Jia, Nicholson, Benjamin, Avery, Bill, Qiu, Huawei, O'Hagan, Ronan, O'Neil, Jennifer

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Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology von Papalia, Giuseppe A., Leavitt, Stephanie, Bynum, Maggie A., Katsamba, Phinikoula S., Wilton, Rosemarie, Qiu, Huawei, Steukers, Mieke, Wang, Siming, Bindu, Lakshman, Phogat, Sanjay, Giannetti, Anthony M., Ryan, Thomas E., Pudlak, Victoria A., Matusiewicz, Katarzyna, Michelson, Klaus M., Nowakowski, Agnes, Pham-Baginski, Anh, Brooks, Jonathan, Tieman, Bryan C., Bruce, Barry D., Vaughn, Michael, Baksh, Michael, Cho, Yun Hee, Wit, Mieke De, Smets, Alexandra, Vandersmissen, Johan, Michiels, Lieve, Myszka, David G.

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Activation of Human Acid Sphingomyelinase through Modification or Deletion of C-terminal Cysteine von Qiu, Huawei, Edmunds, Tim, Baker-Malcolm, Jennifer, Karey, Kenneth P., Estes, Scott, Schwarz, Cordula, Hughes, Heather, Van Patten, Scott M.

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568 XTX201, a protein-engineered IL-2, exhibits tumor-selective activity in mice without peripheral toxicities in non-human primates von Zhang, Minjie, Guzman, Wilson, Johnson, Parker, McLaughlin, Megan, Jenkins, Kurt, Wu, Hsin-Jung, Madala, Hanumantha Rao, O’Toole, Caitlin, Pederzoli-Ribeil, Magali, Rozenfeld, Raphael, Qiu, Huawei, Karow, Margaret, Clackson, Tim, O’Hagan, Ronan, O’Neil, Jennifer, Eskiocak, Ugur

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A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes von Zhao, Hongmei, Karman, Jozsef, Jiang, Ji-Lei, Zhang, Jinhua, Gumlaw, Nathan, Lydon, John, Zhou, Qun, Qiu, Huawei, Jiang, Canwen, Cheng, Seng H, Zhu, Yunxiang

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A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells von Seung, Edward, Xing, Zhen, Wu, Lan, Rao, Ercole, Cortez-Retamozo, Virna, Ospina, Beatriz, Chen, Liqing, Beil, Christian, Song, Zhili, Zhang, Bailin, Levit, Mikhail, Deng, Gejing, Hebert, Andrew, Kirby, Patrick, Li, Aiqun, Poulton, Emma-Jane, Vicente, Rita, Garrigou, Audrey, Piepenhagen, Peter, Ulinski, Greg, Sanicola-Nadel, Michele, Bangari, Dinesh S., Qiu, Huawei, Pao, Lily, Wiederschain, Dmitri, Wei, Ronnie, Yang, Zhi-yong, Nabel, Gary J.

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Clinical poisoning events involving yunaconitine may be highly correlated with metabolism-based interactions: A critical role of CYP3A4 von Li, Xiaocui, Fu, Yu, Qiu, Huawei, Xu, Xueyu, Lin, Tingting, Hou, Weiqing, Chen, Weiying, Zhang, Rong, Liu, Zhongqiu, Zhu, Lijun

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