Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans von Gelernter, Joel, Sun, Ning, Polimanti, Renato, Pietrzak, Robert, Levey, Daniel F., Bryois, Julien, Lu, Qiongshi, Hu, Yiming, Li, Boyang, Radhakrishnan, Krishnan, Aslan, Mihaela, Cheung, Kei-Hoi, Li, Yuli, Rajeevan, Nallakkandi, Sayward, Frederick, Harrington, Kelly, Chen, Quan, Cho, Kelly, Pyarajan, Saiju, Sullivan, Patrick F., Quaden, Rachel, Shi, Yunling, Hunter-Zinck, Haley, Gaziano, J. Michael, Concato, John, Zhao, Hongyu, Stein, Murray B.

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Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci von Gelernter, Joel, Sun, Ning, Polimanti, Renato, Pietrzak, Robert H., Levey, Daniel F., Lu, Qiongshi, Hu, Yiming, Li, Boyang, Radhakrishnan, Krishnan, Aslan, Mihaela, Cheung, Kei-Hoi, Li, Yuli, Rajeevan, Nallakkandi, Sayward, Fred, Harrington, Kelly, Chen, Quan, Cho, Kelly, Honerlaw, Jacqueline, Pyarajan, Saiju, Lencz, Todd, Quaden, Rachel, Shi, Yunling, Hunter-Zinck, Haley, Gaziano, J. Michael, Kranzler, Henry R., Concato, John, Zhao, Hongyu, Stein, Murray B.

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Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism von Lindström, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Damrauer, Scott M., Natarajan, Pradeep, Klarin, Derek, de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, Trégouët, David-Alexandre, Smith, Nicholas L.

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Integration Of Multi Ancestry Osteoarthritis Genetic Association Findings, In Silico Transcriptomics And Drug Repurposing Highlights Mechanism For Efficacy Of Anti-Epileptics For O... von McDonald, M.-L.N., Kumar, P. Lakshman, Srinivasasainagendra, V., Nair, A., Rocco, A., Wilson, A.C., Chiles, J., Richman, J., Pinson, S.A., Dennis, R., Jagadale, V., Brown, C., Pyarajan, S., Tiwari, H.K., Bamman, M., Singh, J.

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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses von Gaziano, Liam, Arnold, Matthew, Bell, Steven, Song, Rebecca J., Burgess, Stephen, Posner, Daniel C., Mosconi, Katja, Robinson-Cohen, Cassianne, Mason, Amy M., Tao, Ran, Allara, Elias, Schubert, Petra, Chen, Lingyan, Staley, James R., Staplin, Natalie, Altay, Servet, Amiano, Pilar, Arndt, Volker, Ärnlöv, Johan, Barr, Elizabeth L.M., Björkelund, Cecilia, Boer, Jolanda M.A., Brenner, Hermann, Casiglia, Edoardo, Chiodini, Paolo, Cooper, Jackie A., Coresh, Josef, Cushman, Mary, Dankner, Rachel, Davidson, Karina W., de Jongh, Renate T., Donfrancesco, Chiara, Engström, Gunnar, Freisling, Heinz, de la Cámara, Agustín Gómez, Gudnason, Vilmundur, Hankey, Graeme J., Hansson, Per-Olof, Heath, Alicia K., Hoorn, Ewout J., Imano, Hironori, Jassal, Simerjot K., Kaaks, Rudolf, Katzke, Verena, Kiechl, Stefan, Koenig, Wolfgang, Kronmal, Richard A., Kyrø, Cecilie, Lawlor, Deborah A., Ljungberg, Börje, MacDonald, Conor, Masala, Giovanna, Meisinger, Christa, Melander, Olle, Moreno Iribas, Conchi, Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Børge G., Onland-Moret, Charlotte, Petrova, Dafina, Garcia, Jose Ramón Quirós, Rosengren, Annika, Sacerdote, Carlotta, Sakurai, Masaru, Santiuste, Carmen, Schulze, Matthias B., Sieri, Sabina, Sundström, Johan, Tikhonoff, Valérie, Tjønneland, Anne, Tong, Tammy, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne T., Monique Verschuren, W.M., Völzke, Henry, Wannamethee, S. Goya, Weiderpass, Elisabete, Willeit, Peter, Yamagishi, Kazumasa, Zamora-Ros, Raul, Akwo, Elvis A., Pyarajan, Saiju, Gagnon, David R., Tsao, Philip S., Muralidhar, Sumitra, Edwards, Todd L., Joseph, Jacob, Pennells, Lisa, Harrison, Seamus, Gaziano, Thomas A., Inouye, Michael, Baigent, Colin, Casas, Juan P., Langenberg, Claudia, Wareham, Nick, Riboli, Elio, Danesh, John, Hung, Adriana M., Di Angelantonio, Emanuele

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High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning von Dhaubhadel, Sayera, Ganguly, Kumkum, Ribeiro, Ruy M., Cohn, Judith D., Hyman, James M., Hengartner, Nicolas W., Kolade, Beauty, Singley, Anna, Bhattacharya, Tanmoy, Finley, Patrick, Levin, Drew, Thelen, Haedi, Cho, Kelly, Costa, Lauren, Ho, Yuk-Lam, Justice, Amy C., Pestian, John, Santel, Daniel, Zamora-Resendiz, Rafael, Crivelli, Silvia, Tamang, Suzanne, Martins, Susana, Trafton, Jodie, Oslin, David W., Beckham, Jean C., Kimbrel, Nathan A., McMahon, Benjamin H.

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Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses von Gaziano, L, Sun, L, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Mason, A, Bolton, TR, Tao, R, Allara, E, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Ärnlöv, J, Barr, ELM, Björkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, De Jongh, RT, Donfrancesco, C, Engström, G, De la Cámara, AG, Gudnason, V, Hankey, GJ, Hansson, P-O, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyrø, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Meisinger, C, Melander, O, Moreno Iribas, C, Ninomiya, T, Nitsch, D, Nordestgaard, BG, Onland-Moret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sakurai, M, Sieri, S, Sundström, J, Tikhonoff, V, Tjønneland, A, Tong, T, Tumino, R, Van der Schouw, YT, Monique Verschuren, WM, Völzke, H, Wallace, RB, Goya Wannamethee, S, Woodward, M, Yamagishi, K, Zamora-Ros, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S, Inouye, M, Million Veteran Program, Baigent, C, Casas, JP, Langenberg, C, Wareham, N, Riboli, E, Michael Gaziano, J, Danesh, J, Hung, AM, Butterworth, AS, Wood, AM, Di Angelantonio, E, Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program

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Genome-wide Association Study of Posttraumatic Stress Disorder (PTSD) Re-Experiencing Symptoms in >165,000 US Veterans von Gelernter, J., Sun, N., Polimanti, R., Pietrzak, R., Levey, Daniel F, Bryois, J., Lu, Q., Hu, Y, Li, B., Radhakrishnan, K., Aslan, M., Cheung, K.H., Li, Y., Rajeevan, N., Sayward, F., Harrington, K., Chen, Q., Cho, K., Pyarajan, S., Sullivan, P.F., Quaden, R., Shi, Y., Hunter-Zinck, H., Gaziano, J. M., Concato, J., Zhao, H., Stein, M.B.

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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 von Gaziano, L, Giambartolomei, C, Pereira, AC, Gaulton, A, Posner, DC, Swanson, SA, Ho, Y-L, Iyengar, SK, Kosik, NM, Vujkovic, M, Gagnon, DR, Bento, AP, Barrio-Hernandez, I, Rönnblom, L, Hagberg, N, Lundtoft, C, Langenberg, C, Pietzner, M, Valentine, D, Gustincich, S, Tartaglia, GG, Allara, E, Surendran, P, Burgess, S, Zhao, JH, Peters, JE, Prins, BP, Angelantonio, ED, Devineni, P, Shi, Y, Lynch, KE, DuVall, SL, Garcon, H, Thomann, LO, Zhou, JJ, Gorman, BR, Huffman, JE, O'Donnell, CJ, Tsao, PS, Beckham, JC, Pyarajan, S, Muralidhar, S, Huang, GD, Ramoni, R, Beltrao, P, Danesh, J, Hung, AM, Chang, K-M, Sun, YV, Joseph, J, Leach, AR, Edwards, TL, Cho, K, Gaziano, JM, Butterworth, AS, Casas, JP, VA Million Veteran Program COVID-19 Science Initiative

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Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder von Deak, Joseph D, Levey, Daniel F, Wendt, Frank R, Zhou, Hang, Galimberti, Marco, Kranzler, Henry R, Gaziano, J Michael, Stein, Murray B, Polimanti, Renato, Gelernter, Joel

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Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin‐mediated killing von Su, Michael Wei‐Chih, Pyarajan, Saiju, Chang, Jin‐Hong, Yu, Chao‐Lan, Jin, Yong‐Jiu, Stierhof, York‐Dieter, Walden, Peter, Burakoff, Steven J.

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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses von Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Robinson-Cohen, C, Mason, AM, Bolton, TR, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Arndt, V, Ärnlöv, J, Barr, ELM, Björkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, De Jongh, RT, Donfrancesco, C, Engström, G, Freisling, H, De La Cámara, AG, Gudnason, V, Hankey, GJ, Hansson, PO, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyrø, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Masala, G, Meisinger, C, Melander, O, Moreno Iribas, C, Ninomiya, T, Nitsch, D, Nordestgaard, BG, Onland-Moret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sacerdote, C, Sakurai, M, Santiuste, C, Schulze, MB, Sieri, S, Sundström, J, Tikhonoff, V, Tjønneland, A, Tong, T, Tumino, R, Tzoulaki, I, Van Der Schouw, YT, Monique Verschuren, WM, Völzke, H, Wallace, RB, Wannamethee, SG, Weiderpass, E, Willeit, P, Woodward, M, Yamagishi, K, Zamora-Ros, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Damrauer, SM, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S

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Million Veteran Program: A mega-biobank to study genetic influences on health and disease von Gaziano, John Michael, Concato, John, Brophy, Mary, Fiore, Louis, Pyarajan, Saiju, Breeling, James, Whitbourne, Stacey, Deen, Jennifer, Shannon, Colleen, Humphries, Donald, Guarino, Peter, Aslan, Mihaela, Anderson, Daniel, LaFleur, Rene, Hammond, Timothy, Schaa, Kendra, Moser, Jennifer, Huang, Grant, Muralidhar, Sumitra, Przygodzki, Ronald, O'Leary, Timothy J

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Pharmacogenetic allele variant frequencies: An analysis of the VA's Million Veteran Program (MVP) as a representation of the diversity in US population von Markianos, Kyriacos, Dong, Frederic, Gorman, Bryan, Shi, Yunling, Dochtermann, Daniel, Saxena, Uma, Devineni, Poornima, Moser, Jennifer, Muralidhar, Sumitra, Ramoni, Rachel, Tsao, Philip, Pyarajan, Saiju, Przygodzki, Ronald

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With equal access, African American patients have superior survival compared to white patients with multiple myeloma: a VA study von Fillmore, Nathanael R., Yellapragada, Sarvari V., Ifeorah, Chizoba, Mehta, Ansh, Cirstea, Diana, White, Paul S., Rivero, Gustavo, Zimolzak, Andrew, Pyarajan, Saiju, Do, Nhan, Brophy, Mary, Munshi, Nikhil C.

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Genetic Architecture of Chronic Back Pain: A Multi-Ancestry Genome-Wide Association Study in The Million Veteran Program von Stanaway, Ian B., Suri, Pradeep, Afari, Niloofar, Dochtermann, Daniel, Pyarajan, Saiju, Roseen, Eric J., Gasperi, Marianna

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Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk von Gorman, Bryan R., Ji, Sun-Gou, Francis, Michael, Sendamarai, Anoop K., Shi, Yunling, Devineni, Poornima, Saxena, Uma, Partan, Elizabeth, DeVito, Andrea K., Byun, Jinyoung, Han, Younghun, Xiao, Xiangjun, Sin, Don D., Timens, Wim, Moser, Jennifer, Muralidhar, Sumitra, Ramoni, Rachel, Hung, Rayjean J., McKay, James D., Bossé, Yohan, Sun, Ryan, Amos, Christopher I., Pyarajan, Saiju

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Genotyping Array Design and Data Quality Control in the Million Veteran Program von Hunter-Zinck, Haley, Shi, Yunling, Li, Man, Gorman, Bryan R., Ji, Sun-Gou, Sun, Ning, Webster, Teresa, Liem, Andrew, Hsieh, Paul, Devineni, Poornima, Karnam, Purushotham, Gong, Xin, Radhakrishnan, Lakshmi, Schmidt, Jeanette, Assimes, Themistocles L., Huang, Jie, Pan, Cuiping, Humphries, Donald, Brophy, Mary, Moser, Jennifer, Muralidhar, Sumitra, Huang, Grant D., Przygodzki, Ronald, Concato, John, Gaziano, John M., Gelernter, Joel, O’Donnell, Christopher J., Hauser, Elizabeth R., Zhao, Hongyu, O’Leary, Timothy J., Tsao, Philip S., Pyarajan, Saiju

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Mo1420 THE IMPACT OF PHENOTYPIC HETEROGENEITY ON GENOME WIDE ASSOCIATION STUDIES OF PANCREATIC DUCTAL ADENOCARCINOMA von Wang, Louise, Zhang, Chi, Larki, Navid Rahimi, Dochtermann, Daniel R., Pyarajan, Saiju, Dewan, Andrew, Voight, Ben, Kember, Rachel, Justice, Amy C., Zhao, Hongyu

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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 von Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

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