Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression von Hughes, Z.A., Neal, S.J., Smith, D.L., Sukoff Rizzo, S.J., Pulicicchio, C.M., Lotarski, S., Lu, S., Dwyer, J.M., Brennan, J., Olsen, M., Bender, C.N., Kouranova, E., Andree, T.H., Harrison, J.E., Whiteside, G.T., Springer, D., O'Neil, S.V., Leonard, S.K., Schechter, L.E., Dunlop, J., Rosenzweig-Lipson, S., Ring, R.H.

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WAY‐318068: a novel, potent and selective noradrenaline re‐uptake inhibitor with activity in rodent models of pain and depression von Whiteside, GT, Dwyer, JM, Harrison, JE, Beyer, CE, Cummons, T, Manzino, L, Mark, L, Johnston, GH, Strassle, BW, Adedoyin, A, Lu, P, Piesla, MJ, Pulicicchio, CM, Erve, JCL, Platt, BJ, Hughes, ZA, Rogers, KE, Deecher, DC, Trybulski, EJ, Kennedy, JD, Zhang, P, Leventhal, L

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Characterization of the alpha-7 nicotinic receptor agonist WYE-103914 in models relevant to schizophrenia and interaction with antipsychotics von Marquis, K.L., Comery, T.A., Navarra, R.L., Leiser, S., Grauer, S.M., Pulicicchio, C., Kelley, C., Roncarati, R., Scali, C., Haydar, S., Ghiron, C., Harrison, B., Robichaud, A., Terstappen, G.C., Dunlop, J.

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Discovery of 6‑Fluoro-5‑(R)‑(3‑(S)‑(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)‑yl)-2-methylphenyl)-2‑(S)‑(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro‑1H‑carbazole-8-carbo... von Watterson, Scott H, De Lucca, George V, Shi, Qing, Langevine, Charles M, Liu, Qingjie, Batt, Douglas G, Beaudoin Bertrand, Myra, Gong, Hua, Dai, Jun, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Wang, Chunlei, Zhang, Yingru, Traeger, Sarah C, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Vickery, Rodney, Discenza, Lorell N, D’Arienzo, Celia J, Zhang, Yifan, Heimrich, Elizabeth, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, McIntyre, Kim W, Galella, Michael A, Tebben, Andy J, Muckelbauer, Jodi K, Chang, ChiehYing, Rampulla, Richard, Mathur, Arvind, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A

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WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel Dopamine D2 Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antips... von Brennan, Julie A, Graf, Radka, Grauer, Steven M, Navarra, Rachel L, Pulicicchio, Claudine M, Hughes, Zoë A, Lin, Qian, Wantuch, Caitlin, Rosenzweig-Lipson, Sharon, Pruthi, Farhana, Lai, Margaret, Smith, Deborah, Goutier, Wouter, van de Neut, Martina, Robichaud, Albert J, Rotella, David, Feenstra, Rolf W, Kruse, Chris, Broqua, Pierre, Beyer, Chad E, McCreary, Andrew C, Pausch, Mark H, Marquis, Karen L

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Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK von Srivastava, Anurag S, Ko, Soo, Watterson, Scott H, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Vickery, Rodney, Discenza, Lorell N, D’Arienzo, Celia J, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, McIntyre, Kim W, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Dai, Jun, Wang, Chunlei, Zhang, Yingru, Wang, Bei, Pawluczyk, Joseph, Kempson, James, Zhao, Rulin, Hou, Xiaoping, Rampulla, Richard, Mathur, Arvind, Galella, Michael A, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A

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Discovery of 6-Fluoro-5-( R )-(3-( S )-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4 H )-yl)-2-methylphenyl)-2-( S )-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1 H -carbazo... von Watterson, Scott H., De Lucca, George V., Shi, Qing, Langevine, Charles M., Liu, Qingjie, Batt, Douglas G., Beaudoin Bertrand, Myra, Gong, Hua, Dai, Jun, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Wang, Chunlei, Zhang, Yingru, Traeger, Sarah C., Pattoli, Mark A., Skala, Stacey, Cheng, Lihong, Obermeier, Mary T., Vickery, Rodney, Discenza, Lorell N., D’Arienzo, Celia J., Zhang, Yifan, Heimrich, Elizabeth, Gillooly, Kathleen M., Taylor, Tracy L., Pulicicchio, Claudine, McIntyre, Kim W., Galella, Michael A., Tebben, Andy J., Muckelbauer, Jodi K., Chang, ChiehYing, Rampulla, Richard, Mathur, Arvind, Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Fura, Aberra, Burke, James R., Tino, Joseph A.

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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-1039... von Marquis, Karen L., Comery, Thomas A., Jow, Flora, Navarra, Rachel L., Grauer, Steven M., Pulicicchio, Claudine, Kelley, Cody, Brennan, Julie A., Roncarati, Renza, Scali, Carla, Haydar, Simon, Ghiron, Chiara, Terstappen, Georg C., Dunlop, John

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WS-50030 [7-{4-[3-(1 H -inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3 H )-one]: A Novel Dopamine D 2 Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical A... von Brennan, Julie A., Graf, Radka, Grauer, Steven M., Navarra, Rachel L., Pulicicchio, Claudine M., Hughes, Zoë A., Lin, Qian, Wantuch, Caitlin, Rosenzweig-Lipson, Sharon, Pruthi, Farhana, Lai, Margaret, Smith, Deborah, Goutier, Wouter, van de Neut, Martina, Robichaud, Albert J., Rotella, David, Feenstra, Rolf W., Kruse, Chris, Broqua, Pierre, Beyer, Chad E., McCreary, Andrew C., Pausch, Mark H., Marquis, Karen L.

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The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT1A Antagonists von Childers, Wayne E, Havran, Lisa M, Asselin, Magda, Bicksler, James J, Chong, Dan C, Grosu, George T, Shen, Zhongqi, Abou-Gharbia, Magid, A, Bach, Alvin C, Harrison, Boyd L, Kagan, Natasha, Kleintop, Teresa, Magolda, Ronald, Marathias, Vasilios, Robichaud, Albert J, Sabb, Annmarie L, Zhang, Mei-Yi, Andree, Terrance H, Aschmies, Susan H, Beyer, Chad, Comery, Thomas A, Day, Mark, Grauer, Steven M, Hughes, Zoe A, Rosenzweig-Lipson, Sharon, Platt, Brian, Pulicicchio, Claudine, Smith, Deborah E, Sukoff-Rizzo, Stacy J, Sullivan, Kelly M, Adedoyin, Adedayo, Huselton, Christine, Hirst, Warren D

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The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT 1A Antagonists von Childers, Wayne E., Havran, Lisa M., Asselin, Magda, Bicksler, James J., Chong, Dan C., Grosu, George T., Shen, Zhongqi, Abou-Gharbia, Magid, A., Bach, Alvin C., Harrison, Boyd L., Kagan, Natasha, Kleintop, Teresa, Magolda, Ronald, Marathias, Vasilios, Robichaud, Albert J., Sabb, Annmarie L., Zhang, Mei-Yi, Andree, Terrance H., Aschmies, Susan H., Beyer, Chad, Comery, Thomas A., Day, Mark, Grauer, Steven M., Hughes, Zoe A., Rosenzweig-Lipson, Sharon, Platt, Brian, Pulicicchio, Claudine, Smith, Deborah E., Sukoff-Rizzo, Stacy J., Sullivan, Kelly M., Adedoyin, Adedayo, Huselton, Christine, Hirst, Warren D.

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