Exome sequencing in multiplex autism families suggests a major role for heterozygous truncating mutations von Toma, C, Torrico, B, Hervás, A, Valdés-Mas, R, Tristán-Noguero, A, Padillo, V, Maristany, M, Salgado, M, Arenas, C, Puente, X S, Bayés, M, Cormand, B

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A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact von Queirós, A C, Villamor, N, Clot, G, Martinez-Trillos, A, Kulis, M, Navarro, A, Penas, E M M, Jayne, S, Majid, A, Richter, J, Bergmann, A K, Kolarova, J, Royo, C, Russiñol, N, Castellano, G, Pinyol, M, Bea, S, Salaverria, I, López-Guerra, M, Colomer, D, Aymerich, M, Rozman, M, Delgado, J, Giné, E, González-Díaz, M, Puente, X S, Siebert, R, Dyer, M J S, López-Otín, C, Rozman, C, Campo, E, López-Guillermo, A, Martín-Subero, J I

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NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome von Villamor, N, Conde, L, Martínez-Trillos, A, Cazorla, M, Navarro, A, Beà, S, López, C, Colomer, D, Pinyol, M, Aymerich, M, Rozman, M, Abrisqueta, P, Baumann, T, Delgado, J, Giné, E, González-Díaz, M, Hernández, J M, Colado, E, Payer, A R, Rayon, C, Navarro, B, José Terol, M, Bosch, F, Quesada, V, Puente, X S, López-Otín, C, Jares, P, Pereira, A, Campo, E, López-Guillermo, A

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Genome analysis of the platypus reveals unique signatures of evolution von WARREN, Wesley C, HILLIER, Ladeana W, YANG, Shiaw-Pyng, HEGER, Andreas, LOCKE, Devin P, MIETHKE, Pat, WATERS, Paul D, VEYRUNES, Frédéric, FULTON, Lucinda, FULTON, Bob, GRAVES, Tina, WALLIS, John, MARSHALL GRAVES, Jennifer A, PUENTE, Xose S, LOPEZ-OTIN, Carlos, ORDONEZ, Gonzalo R, EICHLER, Evan E, LIN CHEN, ZE CHENG, DEAKIN, Janine E, ALSOP, Amber, THOMPSON, Katherine, KIRBY, Patrick, BIRNEY, Ewan, PAPENFUSS, Anthony T, WAKEFIELD, Matthew J, OLENDER, Tsviya, LANCET, Doron, HUTTLEY, Gavin A, SMIT, Arian F. A, PASK, Andrew, TEMPLE-SMITH, Peter, BATZER, Mark A, WALKER, Jerilyn A, PONTING, Chris P, KONKEL, Miriam K, HARRIS, Robert S, WHITTINGTON, Camilla M, WONG, Emily S. W, GEMMELL, Neil J, BUSCHIAZZO, Emmanuel, VARGAS JENTZSCH, Iris M, MERKEL, Angelika, SCHMITZ, Juergen, ZEMANN, Anja, GRUTZNER, Frank, CHURAKOV, Gennady, KRIEGS, Jan Ole, BROSIUS, Juergen, MURCHISON, Elizabeth P, SACHIDANANDAM, Ravi, SMITH, Carly, HANNON, Gregory J, TSEND-AYUSH, Enkhjargal, MCMILLAN, Daniel, ATTENBOROUGH, Rosalind, BELOV, Katherine, MILLER, Webb, CLARKE, Laura, CHINWALLA, Asif T

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Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia von Ramsay, A J, Rodríguez, D, Villamor, N, Kwarciak, A, Tejedor, J R, Valcárcel, J, López-Guillermo, A, Martínez-Trillos, A, Puente, X S, Campo, E, López-Otín, C, Quesada, V

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Human organic cation transporter 1 cells von Arimany-Nardi, C, Montraveta, A, Lee-Verges, E, Puente, X.S, Koepsell, H, Campo, E, Colomer, D, Pastor-Anglada, M

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PS1147 SPATIAL HETEROGENEITY IN CHRONIC LYMPHOCYTIC LEUKAEMIA ANALYSED BY WHOLE‐GENOME/EXOME SEQUENCING AT DIAGNOSIS von Nadeu, F., Royo, R., Maura, F., Dawson, K.J., Dueso, A., Torrents, D., Aymerich, M., Pinyol, M., Beà, S., López‐Guillermo, A., Delgado, J., Puente, X.S., Campo, E.

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PF355 INTEGRATION OF GENOMIC AND EPIGENOMIC DATA REFINES THE REGULATORY MECHANISMS AND BIOLOGICAL SIGNIFICANCE OF CHRONIC LYMPHOCYTIC LEUKEMIA RISK LOCI von Beekman, R., Speedy, H.E., Chapaprieta, V., Orlando, G., Law, P.J., Martín‐García, D., Gutiérrez‐Abril, J., Catovsky, D., Beà, S., Clot, G., Puiggros, M., Torrents, D., Puente, X.S., Allan, J.M., López‐Otín, C., Campo, E., Houlston, R.S., Martín‐Subero, J.I.

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S843 THE PROLIFERATIVE HISTORY SHAPES THE DNA METHYLOME OF B‐CELL TUMORS AND PREDICTS CLINICAL OUTCOME von Duran‐Ferrer, M., Clot, G., Nadeu, F., Beekman, R., Baumann, T., Nordlund, J., Marincevic‐Zuniga, Y., Rivas‐Delgado, A., Ordoñez, R., Castellano, G., Kulis, M., Queirós, A., Seung‐Tae, L., Wiemels, J., Royo, R., Puiggrós, M., Torrents, D., Giné, E., Beà, S., Jares, P., Agirre, X., Prosper, F., López‐Otín, C., Puente, X.S., Delgado, J., López‐Guillermo, A., Campo, E., Martín‐Subero, J.I.

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Ole e 3, an olive-tree allergen, belongs to a widespread family of pollen proteins von Batanero, E, Villalba, M, Ledesma, A, Puente, X.S, Rodriguez, R

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Divergence in properties of two closely related alfa-amylase inhibitors of barley von Garcia Casado G, Sanchez Monge R, Puente X.S, Salcedo G

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