Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts von Huang, S K, Scruggs, A M, Donaghy, J, Horowitz, J C, Zaslona, Z, Przybranowski, S, White, E S, Peters-Golden, M

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo von Sebolt-Leopold, Judith S., Dudley, David T., Herrera, Roman, Becelaere, Keri Van, Wiland, Amy, Gowan, Richard C., Tecle, Haile, Barrett, Stephen D., Bridges, Alexander, Przybranowski, Sally, Leopold, W.R., Saltiel, Alan R.

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B101 ASTHMA PATHOGENESIS: Resident Alveolar Macrophages Suppress While Recruited Macrophages Promote Allergic Lung Inflammation In Murine Models Of Asthma von Zaslona, Z, Przybranowski, S, Wilke, C, Rooijen, N Van, Moore, B B, Peters-Golden, M

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A Role for K-ras in Conferring Resistance to the MEK Inhibitor, CI-1040 von Wangab, Yuli, Van Becelaere, Keri, Jiang, Ping, Przybranowski, Sally, Omer, Charles, Sebolt-Leopold, Judith

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Cellular transport of CI-980 von HOOK, K. E, PRZYBRANOWSKI, S. A, LEOPOLD, W. R

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Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice von KUNKEL, M. W, HOOK, K. E, HOWARD, C. T, PRZYBANOWSKI, S, ROBERTS, B. J, ELLIOTT, W. L, LEOPOLD, W. R

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Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumo... von Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Induc... von Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer von Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Jiang, Hui, Hu, Jiantao, Xu, Fuming, Zhao, Yujun, Liu, Liu, Fernandez-Salas, Ester, Xu, Jing, Dou, Yali, Wen, Bo, Sun, Duxin, Meagher, Jennifer, Stuckey, Jeanne, Hayes, Daniel F, Li, Shunqiang, Ellis, Matthew J, Wang, Shaomeng

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Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling von Bourdonnay, Emilie, Zasłona, Zbigniew, Penke, Loka Raghu Kumar, Speth, Jennifer M, Schneider, Daniel J, Przybranowski, Sally, Swanson, Joel A, Mancuso, Peter, Freeman, Christine M, Curtis, Jeffrey L, Peters-Golden, Marc

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Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma von Zasłona, Zbigniew, Przybranowski, Sally, Wilke, Carol, van Rooijen, Nico, Teitz-Tennenbaum, Seagal, Osterholzer, John J, Wilkinson, John E, Moore, Bethany B, Peters-Golden, Marc

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Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression von Zhou, Bing, Hu, Jiantao, Xu, Fuming, Chen, Zhuo, Bai, Longchuan, Fernandez-Salas, Ester, Lin, Mei, Liu, Liu, Yang, Chao-Yie, Zhao, Yujun, McEachern, Donna, Przybranowski, Sally, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901 von Barrett, Stephen D., Bridges, Alexander J., Dudley, David T., Saltiel, Alan R., Fergus, James H., Flamme, Cathlin M., Delaney, Amy M., Kaufman, Michael, LePage, Sophie, Leopold, Wilbur R., Przybranowski, Sally A., Sebolt-Leopold, Judith, Van Becelaere, Keri, Doherty, Annette M., Kennedy, Robert M., Marston, Dan, Howard, W. Allen, Smith, Yvonne, Warmus, Joseph S., Tecle, Haile

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Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-car... von Aguilar, Angelo, Lu, Jianfeng, Liu, Liu, Du, Ding, Bernard, Denzil, McEachern, Donna, Przybranowski, Sally, Li, Xiaoqin, Luo, Ruijuan, Wen, Bo, Sun, Duxin, Wang, Hengbang, Wen, Jianfeng, Wang, Guangfeng, Zhai, Yifan, Guo, Ming, Yang, Dajun, Wang, Shaomeng

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Discovery of M‑808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity von Xu, Shilin, Aguilar, Angelo, Huang, Liyue, Xu, Tianfeng, Zheng, Ke, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Zawacki, Kaitlin, Liu, Zhaomin, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng

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Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction von Xu, Shilin, Aguilar, Angelo, Xu, Tianfeng, Zheng, Ke, Huang, Liyue, Stuckey, Jeanne, Chinnaswamy, Krishnapriya, Bernard, Denzil, Fernández‐Salas, Ester, Liu, Liu, Wang, Mi, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Wang, Shaomeng

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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras von Lauchle, Jennifer O., Kim, Doris, Le, Doan T., Akagi, Keiko, Crone, Michael, Krisman, Kimberly, Warner, Kegan, Bonifas, Jeannette M., Li, Qing, Coakley, Kristen M., Diaz-Flores, Ernesto, Gorman, Matthew, Przybranowski, Sally, Tran, Mary, Kogan, Scott C., Roose, Jeroen P., Copeland, Neal G., Jenkins, Nancy A., Parada, Luis, Wolff, Linda, Sebolt-Leopold, Judith, Shannon, Kevin

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Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy von Deng, Jing, Paulus, Aneel, Fang, Douglas D, Manna, Alak, Wang, Guangfeng, Wang, Hengbang, Zhu, Saijie, Chen, Jianyong, Min, Ping, Yin, Yan, Dutta, Navnita, Halder, Nabanita, Ciccio, Gina, Copland, John A, Miller, James, Han, Bing, Bai, Longchuan, Liu, Liu, Wang, Mi, McEachern, Donna, Przybranowski, Sally, Yang, Chao-Yie, Stuckey, Jeanne A, Wu, Depei, Li, Caixia, Ryan, Jeremy, Letai, Anthony, Ailawadhi, Sikander, Yang, Dajun, Wang, Shaomeng, Chanan-Khan, Asher, Zhai, Yifan

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Abstract 4870: Targeted MDM2 degradation as a novel and efficacious cancer therapy von Yang, Jiuling, Li, Yangbing, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Fernandez-Salas, Ester, Lu, Jianfeng

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Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor von Zhao, Yujun, Zhou, Bing, Bai, Longchuan, Liu, Liu, Yang, Chao-Yie, Meagher, Jennifer L, Stuckey, Jeanne A, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Ran, Xu, Aguilar, Angelo, Hu, Yang, Kampf, Jeff W, Li, Xiaoqin, Zhao, Ting, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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