Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential von Buys, E.S., Zimmer, D.P., Chickering, J., Graul, R., Chien, Y.T., Profy, A., Hadcock, J.R., Masferrer, J.L., Milne, G.T.

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PRO 2000 Gel Inhibits HIV and Herpes Simplex Virus Infection Following Vaginal Application: A Double-Blind Placebo-Controlled Trial von Keller, Marla J., Zerhouni-Layachi, Bouchra, Cheshenko, Natalia, John, Minnie, Hogarty, Kathleen, Kasowitz, Andrea, Goldberg, Cindy L., Wallenstein, Sylvan, Profy, Albert T., Klotman, Mary E., Herold, Betsy C.

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Principal Neutralizing Domain of the Human Immunodeficiency Virus Type 1 Envelope Protein von Javaherian, Kashi, Langlois, Alphonse J., McDanal, Charlene, Ross, Karen L., Eckler, Lawrence I., Jellis, Cindy L., Profy, Albert T., Rusche, James R., Bolognesi, Dani P., Putney, Scott D., Matthews, Thomas J.

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Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing Fabs von Stanfield, RL, Cabezas, E, Satterthwait, AC, Stura, EA, Profy, AT, Wilson, IA

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Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread von CHESHENKO, Natalia, KELLER, Marla J, ZANEVELD, Lourens J. D, PROFY, Albert T, KLOTMAN, Mary E, HEROLD, Betsy C, MASCASULLO, Veronica, JARVIS, Gary A, HUI CHENG, JOHN, Minnie, LI, Jin-Hua, HOGARTY, Kathleen, ANDERSON, Robert A, WALLER, Donald P

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Crystal Structure of the Principal Neutralization Site of HIV-1 von Ghiara, Jayant B., Stura, Enrico A., Stanfield, Robyn L., Profy, Albert T., Wilson, Ian A.

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Crystal Structure of a Human Immunodeficiency Virus Type 1 Neutralizing Antibody, 50.1, in Complex with Its V3 Loop Peptide Antigen von Rini, James M., Stanfield, Robyn L., Stura, Enrico A., Salinas, Paul A., Profy, Albert T., Wilson, Ian A.

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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities von RUSCONI, S, MOONIS, M, HIRSCH, M. S, MERRILL, D. P, PALLAI, P. V, NEIDHARDT, E. A, SINGH, S. K, WILLIS, K. J, OSBURNE, M. S, PROFY, A. T, JENSON, J. C

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Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant von LaRosa, Gregory J., Davide, Joseph P., Weinhold, Kent, Waterbury, Julie A., Profy, Albert T., Lewis, John A., Langlois, Alphonse J., Dreesman, Gordon R., Boswell, R. Neal, Shadduck, Phillip, Holley, L. Howard, Karplus, Martin, Bolognesi, Dani P., Matthews, Thomas J., Emini, Emilio A., Putney, Scott D.

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Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1 von Javaherian, Kashi, Langlois, Alphonse J., LaRosa, Greg J., Profy, Albert T., Bolognesi, Dani P., Herlihy, Walter C., Putney, Scott D., Matthews, Thomas J.

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Predictive Power of an In Vitro System to Assess Drug Interactions of an Antimuscarinic Medication: A Comparison of In Vitro and In Vivo Drug-Drug Interaction Studies of Trospium C... von Sandage, B., Sabounjian, L., Shipley, J., Profy, A., Lasseter, K., Fox, L., Harnett, M.

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The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model von Bourne, Nigel, Bernstein, David I., Ireland, James, Sonderfan, Andrew J., Profy, Albert T., Stanberry, Lawrence R.

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Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop von Stanfield, Robyn L, Ghiara, Jayant B, Ollmann Saphire, Erica, Profy, Albert T, Wilson, Ian A

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A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women von Van Damme, L, Wright, A, Depraetere, K, Rosenstein, I, Vandersmissen, V, Poulter, L, McKinlay, M, Van Dyck, E, Weber, J, Profy, A, Laga, M, Kitchen, V

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Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study von LACEY, Charles J. N, WRIGHT, Anne, WEBER, Jonathan N, PROFY, Albert T

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PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity von KELLER, Marla J, GUZMAN, Esmeralda, HOGARTY, Kathleen, HEROLD, Betsy C, HAZRATI, Ehsan, KASOWITZ, Andrea, CHESHENKO, Natalia, WALLENSTEIN, Sylvan, COLE, Amy L, COLE, Alexander M, PROFY, Albert T, WIRA, Charles R

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Major antigen-induced domain rearrangements in an antibody von Stanfield, Robyn L, Takimoto-Kamimura, Midori, Rini, James M, Profy, Albert T, Wilson, Ian A

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The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1 von Huskens, Dana, Vermeire, Kurt, Profy, Albert T., Schols, Dominique

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HPTN 035 phase II/IIb randomised safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 for the prevention of sexually transmitted infections in wom... von Guffey, M Bradford, Richardson, Barbra, Husnik, Marla, Makanani, Bonus, Chilongozi, David, Yu, Elmer, Ramjee, Gita, Mgodi, Nyaradzo, Gomez, Kailazarid, Hillier, Sharon L, Karim, Salim Abdool

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Safety and Acceptability of Penile Application of 2 Candidate Topical Microbicides: BufferGel and PRO 2000 Gel: 3 Randomized Trials in Healthy Low-Risk Men and HIV-Positive Men von Tabet, Stephen R, Callahan, Marianne M, Mauck, Christine K, Gai, Fang, Coletti, Anne S, Profy, Albert T, Moench, Thomas R, Soto-Torres, Lydia E, Poindexter, Alfred N, Frezieres, Ron G, Walsh, Terri L, Kelly, Clifton W, Richardson, Barbra A, van Damme, Lut, Celum, Constance L

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