Making Better Drugs: Decision Gates in Non-Clinical Drug Development von Pritchard, J. Fred, Jurima-Romet, Malle, Reimer, Mark L. J, Mortimer, Elisabeth, Rolfe, Brenda, Cayen, Mitchell N

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Validation of a liquid chromatography post-column derivatization assay for the determination of cisplatin in plasma von Farrish, H.H., Hsyu, P.-H., Pritchard, J.F., Brouwer, K.R., Jarrett, J.

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Scraper winch motors on South African gold mines-an investigation into their failure von Pritchard, J.F., Landy, C.F.

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Culturing two-to eight-cell caprine embryos using domestic chicken eggs von Blakewood, E.G., Pool, S.H., Pritchard, J.F., Godke, R.A.

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Linear model of a closed three-shaft Brayton cycle von van Niekerk, C.R., van Schoor, G., Pritchard, J.F.

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Stability of Aroclor 1254-induced rat liver postmitochondrial supernatant (S-9) following long-term storage (-75 degrees C) von Oldham, J.W, Pritchard, J.F, Preston, R.F, Nomides, C.T, Patton, W.E, Paulson, J.D

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A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma von Wadt, K.A.W., Aoude, L.G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M.T., Kiilgaard, J.F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J.F., McCarthy, S.W., Goodwin, A., Tsao, H., Jönsson, G., Busam, K., Gupta, R., Trent, J.M., Gerdes, A.-M., Brown, K.M., Scolyer, R.A., Hayward, N.K.

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Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN von Gleitz, Hélène F.E., Dugourd, Aurélien J.F., Leimkühler, Nils B., Snoeren, Inge A.M., Fuchs, Stijn N.R., Menzel, Sylvia, Ziegler, Susanne, Kröger, Nicolaus, Triviai, Ioanna, Büsche, Guntram, Kreipe, Hans, Banjanin, Bella, Pritchard, Jessica E., Hoogenboezem, Remco, Bindels, Eric M., Schumacher, Neele, Rose-John, Stefan, Elf, Shannon, Saez-Rodriguez, Julio, Kramann, Rafael, Schneider, Rebekka K.

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Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins von Miller, Lisa M, Pritchard, John M, Macdonald, Simon J F, Jamieson, Craig, Watson, Allan J B

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Dickeya solani sp. nov., a pectinolytic plant-pathogenic bacterium isolated from potato (Solanum tuberosum) von van der Wolf, Jan M, Nijhuis, Els H, Kowalewska, Malgorzata J, Saddler, Gerry S, Parkinson, Neil, Elphinstone, John G, Pritchard, Leighton, Toth, Ian K, Lojkowska, Ewa, Potrykus, Marta, Waleron, Malgorzata, de Vos, Paul, Cleenwerck, Ilse, Pirhonen, Minna, Garlant, Linda, Hélias, Valérie, Pothier, Joël F, Pflüger, Valentin, Duffy, Brion, Tsror, Leah, Manulis, Shula

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Lead Optimization Using Matched Molecular Pairs: Inclusion of Contextual Information for Enhanced Prediction of hERG Inhibition, Solubility, and Lipophilicity von Papadatos, George, Alkarouri, Muhammad, Gillet, Valerie J, Willett, Peter, Kadirkamanathan, Visakan, Luscombe, Christopher N, Bravi, Gianpaolo, Richmond, Nicola J, Pickett, Stephen D, Hussain, Jameed, Pritchard, John M, Cooper, Anthony W. J, Macdonald, Simon J. F

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Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis von Anderson, Niall A, Campos, Sebastien, Butler, Sharon, Copley, Royston C. B, Duncan, Ian, Harrison, Stephen, Le, Joelle, Maghames, Rosemary, Pastor-Garcia, Aleix, Pritchard, John M, Rowedder, James E, Smith, Claire E, Thomas, Jack, Vitulli, Giovanni, Macdonald, Simon J. F

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Structure–Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode von Miller, Lisa M, Keune, Willem-Jan, Castagna, Diana, Young, Louise C, Duffy, Emma L, Potjewyd, Frances, Salgado-Polo, Fernando, Engel García, Paloma, Semaan, Dima, Pritchard, John M, Perrakis, Anastassis, Macdonald, Simon J. F, Jamieson, Craig, Watson, Allan J. B

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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor(3S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)‑1-methyl-3-(2-(5,6,7,8-tetra... von Barrett, Tim N, Taylor, Jonathan A, Barker, Daniel, Procopiou, Panayiotis A, Thompson, James D. F, Barrett, John, Le, Joelle, Lynn, Sean M, Pogany, Peter, Pratley, Cassie, Pritchard, John M, Roper, James A, Rowedder, James E, Slack, Robert J, Vitulli, Giovanni, Macdonald, Simon J. F, Kerr, William J

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Elevated circulating and placental SPINT2 is associated with placental dysfunction von Murphy, C.N, Walker, S.P, Macdonald, T.M, Keenan, E, Hannan, N.J, Wlodek, M.E, Myers, J, Briffa, J.F, Romano, T, Roddy Mitchell, A, Whigham, C.-A, Cannon, P, Nguyen, T.-V, Kandel, M, Pritchard, N, Tong, S, Kaitu’u-lino, T.J

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Discovery of (S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((R)‑3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin I... von Procopiou, Panayiotis A, Anderson, Niall A, Barrett, John, Barrett, Tim N, Crawford, Matthew H. J, Fallon, Brendan J, Hancock, Ashley P, Le, Joelle, Lemma, Seble, Marshall, Richard P, Morrell, Josie, Pritchard, John M, Rowedder, James E, Saklatvala, Paula, Slack, Robert J, Sollis, Steven L, Suckling, Colin J, Thorp, Lee R, Vitulli, Giovanni, Macdonald, Simon J. F

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Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis von Anderson, Niall A, Campbell, Ian B, Fallon, Brendan J, Lynn, Sean M, Macdonald, Simon J F, Pritchard, John M, Procopiou, Panayiotis A, Sollis, Steven L, Thorp, Lee R

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Do alternative methods of measuring tumor size, including consideration of multicentric/multifocal disease, enhance prognostic information beyond TNM staging in women with early st... von Hilton, J. F., Bouganim, N., Dong, B., Chapman, J. W., Arnaout, A., O’Malley, F., Gelmon, K. A., Yerushalmi, R., Levine, M. N., Bramwell, V. H. C., Whelan, T. J., Pritchard, K. I., Shepherd, L. E., Clemons, M.

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Analysis of Neighborhood Behavior in Lead Optimization and Array Design von Papadatos, George, Cooper, Anthony W. J, Kadirkamanathan, Visakan, Macdonald, Simon J. F, McLay, Iain M, Pickett, Stephen D, Pritchard, John M, Willett, Peter, Gillet, Valerie J

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Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method von Barker, Mike, Clackers, Margaret, Demaine, Derek A, Humphreys, Davina, Johnston, Michael J, Jones, Haydn T, Pacquet, Francois, Pritchard, John M, Salter, Mark, Shanahan, Stephen E, Skone, Philip A, Vinader, Victoria M, Uings, Iain, McLay, Iain M, Macdonald, Simon J. F

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