Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations von Prins, Bram P., Kuchenbaecker, Karoline B., Bao, Yanchun, Smart, Melissa, Zabaneh, Delilah, Fatemifar, Ghazaleh, Luan, Jian’an, Wareham, Nick J., Scott, Robert A., Perry, John R. B., Langenberg, Claudia, Benzeval, Michaela, Kumari, Meena, Zeggini, Eleftheria

Volltext

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age von Harris, Sarah E., Cox, Simon R., Bell, Steven, Marioni, Riccardo E., Prins, Bram P., Pattie, Alison, Corley, Janie, Muñoz Maniega, Susana, Valdés Hernández, Maria, Morris, Zoe, John, Sally, Bronson, Paola G., Tucker-Drob, Elliot M., Starr, John M., Bastin, Mark E., Wardlaw, Joanna M., Butterworth, Adam S., Deary, Ian J.

Volltext

Genomic atlas of the human plasma proteome von Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

Volltext

Genetics of coronary artery disease: Genome-wide association studies and beyond von Prins, Bram P, Lagou, Vasiliki, Asselbergs, Folkert W, Snieder, Harold, Fu, Jingyuan

Volltext

Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study von Sleiman, Patrick M., Qu, Hui‐Qi, Connolly, John J., Mentch, Frank, Pereira, Alexandre, Lotufo, Paulo A., Tollman, Stephen, Choudhury, Ananyo, Ramsay, Michele, Kato, Norihiro, Ozaki, Kouichi, Mitsumori, Risa, Jeon, Jae‐Pil, Hong, Chang Hyung, Son, Sang Joon, Roh, Hyun Woong, Lee, Dong‐gi, Mukadam, Naaheed, Foote, Isabelle F., Marshall, Charles R., Butterworth, Adam, Prins, Bram P., Glessner, Joseph T., Hakonarson, Hakon

Volltext

Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study von Amini, Marzyeh, Bashirova, Dinara, Prins, Bram P, Corpeleijn, Eva, Bruinenberg, Marcel, Franke, Lude, Harst, Pim van der, Navis, Gerjan, Wolffenbuttel, Bruce H R, Stolk, Ronald P, Wijmenga, Cisca, Postma, Dirkje S, Koppelman, Gerard H, Boezen, H Marike, Vonk, Judith, Snieder, Harold, Alizadeh, Behrooz Z

Volltext

QCGWAS: A flexible R package for automated quality control of genome-wide association results von van der Most, Peter J, Vaez, Ahmad, Prins, Bram P, Munoz, M Loretto, Snieder, Harold, Alizadeh, Behrooz Z, Nolte, Ilja M

Volltext

lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection von Vaez, Ahmad, van der Most, Peter J, Prins, Bram P, Snieder, Harold, van den Heuvel, Edwin, Alizadeh, Behrooz Z, Nolte, Ilja M

Volltext

Beyond Genome-Wide Association Studies: New Strategies for Identifying Genetic Determinants of Hypertension von Wang, Xiaoling, Prins, Bram P., Sõber, Siim, Laan, Maris, Snieder, Harold

Volltext

Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study von Amini, Marzyeh, Vonk, Judith M., Abbasi, Ali, Prins, Bram P., Bruinenberg, Marcel, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Koppelman, Gerard H., Wolffenbuttel, Bruce H. R., Boezen, H. Marike, Snieder, Harold, Chasman, Daniel I., Alizadeh, Behrooz Z.

Volltext

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons von Vaez, Ahmad, Jansen, Rick, Prins, Bram P, Hottenga, Jouke-Jan, de Geus, Eco J C, Boomsma, Dorret I, Penninx, Brenda W J H, Nolte, Ilja M, Snieder, Harold, Alizadeh, Behrooz Z

Volltext

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals von Ntalla, Ioanna, Karthikeyan, Savita, Mifsud, Borbala, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Prins, Bram P., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Bielak, Lawrence F., Brody, Jennifer A., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Franceschini, Nora, Gao, He, Giulianini, Franco, Hwang, Shih-Jen, Kanoni, Stavroula, Lindström, Jaana, Luan, Jian’an, Mahajan, Anubha, Malerba, Giovanni, Perola, Markus, Richard, Melissa, Richardson, Tom G., Sepúlveda, Nuno, Thériault, Sébastien, Trompet, Stella, Varga, Tibor V., Velez Edwards, Digna R., Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Young, Robin, Zhang, Weihua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Mutsert, Renée de, Dörr, Marcus, Gaziano, J. Michael, Have, Christian T., Kajantie, Eero, Kamat, Mihir, Karpe, Fredrik, Koistinen, Heikki A., Moitry, Marie, Peters, James, Rossouw, Jacques, Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan V., Trabetti, Elisabetta, Vaartjes, Ilonca, Buring, Julie E., Chowdhury, Rajiv, Correa, Adolfo, Deary, Ian J., Deloukas, Panos, Ferrières, Jean, Fornage, Myriam, Gaunt, Tom R., Harris, Tamara B., Järvelin, Marjo-Riitta, Kooperberg, Charles, Launer, Lenore J., Majumder, Abdulla al Shafi, Laakso, Markku, Melander, Olle, Mohlke, Karen L., Orho-Melander, Marju, Palmas, Walter, Polasek, Ozren, Province, Michael A., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome I., Samani, Nilesh J., Soranzo, Nicole, Spector, Timothy D., Starr, John M., van der Harst, Pim, van der Meer, Peter, Verweij, Niek, Virtamo, Jarmo, Wareham, Nicholas J., Langenberg, Claudia, Liu, Chunyu, Manning, Alisa K., Morrison, Alanna C., O’Donnell, Christopher J., Saleheen, Danish, Boerwinkle, Eric, Chasman, Daniel I.

Volltext

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 von Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

Volltext

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study von Prins, Bram P, Abbasi, Ali, Wong, Anson, Vaez, Ahmad, Nolte, Ilja, Franceschini, Nora, Stuart, Philip E, Guterriez Achury, Javier, Mistry, Vanisha, Bradfield, Jonathan P, Valdes, Ana M, Bras, Jose, Shatunov, Aleksey, Lu, Chen, Han, Buhm, Raychaudhuri, Soumya, Bevan, Steve, Mayes, Maureen D, Tsoi, Lam C, Evangelou, Evangelos, Nair, Rajan P, Grant, Struan F A, Polychronakos, Constantin, Radstake, Timothy R D, van Heel, David A, Dunstan, Melanie L, Wood, Nicholas W, Al-Chalabi, Ammar, Dehghan, Abbas, Hakonarson, Hakon, Markus, Hugh S, Elder, James T, Knight, Jo, Arking, Dan E, Spector, Timothy D, Koeleman, Bobby P C, van Duijn, Cornelia M, Martin, Javier, Morris, Andrew P, Weersma, Rinse K, Wijmenga, Cisca, Munroe, Patricia B, Perry, John R B, Pouget, Jennie G, Jamshidi, Yalda, Snieder, Harold, Alizadeh, Behrooz Z

Volltext

Rare variant associations with plasma protein levels in the UK Biobank von Dhindsa, Ryan S., Burren, Oliver S., Sun, Benjamin B., Prins, Bram P., Matelska, Dorota, Wheeler, Eleanor, Mitchell, Jonathan, Oerton, Erin, Hristova, Ventzislava A., Smith, Katherine R., Carss, Keren, Wasilewski, Sebastian, Harper, Andrew R., Paul, Dirk S., Fabre, Margarete A., Runz, Heiko, Viollet, Coralie, Challis, Benjamin, Platt, Adam, Vitsios, Dimitrios, Ashley, Euan A., Whelan, Christopher D., Pangalos, Menelas N., Wang, Quanli, Petrovski, Slavé

Volltext

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study von Behr, Elijah R, Savio-Galimberti, Eleonora, Barc, Julien, Holst, Anders G, Petropoulou, Evmorfia, Prins, Bram P, Jabbari, Javad, Torchio, Margherita, Berthet, Myriam, Mizusawa, Yuka, Yang, Tao, Nannenberg, Eline A, Dagradi, Federica, Weeke, Peter, Bastiaenan, Rachel, Ackerman, Michael J, Haunso, Stig, Leenhardt, Antoine, Kääb, Stefan, Probst, Vincent, Redon, Richard, Sharma, Sanjay, Wilde, Arthur, Tfelt-Hansen, Jacob, Schwartz, Peter, Roden, Dan M, Bezzina, Connie R, Olesen, Morten, Darbar, Dawood, Guicheney, Pascale, Crotti, Lia, Jamshidi, Yalda

Volltext

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals von Ntalla, Ioanna, Karthikeyan, Savita, Mifsud, Borbala, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Prins, Bram P., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Bielak, Lawrence F., Brody, Jennifer A., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Franceschini, Nora, Gao, He, Giulianini, Franco, Hwang, Shih-Jen, Kanoni, Stavroula, Lindström, Jaana, Luan, Jian’an, Mahajan, Anubha, Malerba, Giovanni, Perola, Markus, Richard, Melissa, Richardson, Tom G., Sepúlveda, Nuno, Thériault, Sébastien, Trompet, Stella, Varga, Tibor V., Velez Edwards, Digna R., Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Young, Robin, Zhang, Weihua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Mutsert, Renée de, Dörr, Marcus, Gaziano, J. Michael, Have, Christian T., Kajantie, Eero, Kamat, Mihir, Karpe, Fredrik, Moitry, Marie, Peters, James, Rossouw, Jacques, Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan V., Trabetti, Elisabetta, Vaartjes, Ilonca, Buring, Julie E., Chowdhury, Rajiv, Correa, Adolfo, Deary, Ian J., Deloukas, Panos, Ferrières, Jean, Fornage, Myriam, Gaunt, Tom R., Harris, Tamara B., Järvelin, Marjo-Riitta, Kooperberg, Charles, Launer, Lenore J., Lind, Lars, Majumder, Abdulla al Shafi, Laakso, Markku, Melander, Olle, Mohlke, Karen L., Orho-Melander, Marju, Palmas, Walter, Polasek, Ozren, Province, Michael A., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome I., Samani, Nilesh J., Soranzo, Nicole, Spector, Timothy D., Starr, John M., van der Harst, Pim, van der Meer, Peter, Verweij, Niek, Virtamo, Jarmo, Wareham, Nicholas J., Langenberg, Claudia, Liu, Chunyu, Manning, Alisa K., Morrison, Alanna C., O’Donnell, Christopher J., Saleheen, Danish, Boerwinkle, Eric, Chasman, Daniel I.

Volltext

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function von Aschard, Hugues, Tobin, Martin D, Hancock, Dana B, Skurnik, David, Sood, Akshay, James, Alan, Vernon Smith, Albert, Manichaikul, Ani W, Campbell, Archie, Prins, Bram P, Hayward, Caroline, Loth, Daan W, Porteous, David J, Strachan, David P, Zeggini, Eleftheria, O'Connor, George T, Brusselle, Guy G, Boezen, H Marike, Schulz, Holger, Deary, Ian J, Hall, Ian P, Rudan, Igor, Kaprio, Jaakko, Wilson, James F, Wilk, Jemma B, Huffman, Jennifer E, Hua Zhao, Jing, de Jong, Kim, Lyytikäinen, Leo-Pekka, Wain, Louise V, Jarvelin, Marjo-Riitta, Kähönen, Mika, Fornage, Myriam, Polasek, Ozren, Cassano, Patricia A, Barr, R Graham, Rawal, Rajesh, Harris, Sarah E, Gharib, Sina A, Enroth, Stefan, Heckbert, Susan R, Lehtimäki, Terho, Gyllensten, Ulf, Jackson, Victoria E, Gudnason, Vilmundur, Tang, Wenbo, Dupuis, Josée, Soler Artigas, María, Joshi, Amit D, London, Stephanie J, Kraft, Peter

Volltext

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 von Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

Volltext

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 von Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C, Gaulton, Anna, Posner, Daniel C, Swanson, Sonja A, Ho, Yuk-Lam, Iyengar, Sudha K, Kosik, Nicole M, Vujkovic, Marijana, Gagnon, David R, Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E, Prins, Bram P, Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E, DuVall, Scott L, Garcon, Helene, Thomann, Lauren O, Zhou, Jin J, Gorman, Bryan R, Huffman, Jennifer E, O’Donnell, Christopher J, Tsao, Philip S, Beckham, Jean C, Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D, Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M, Chang, Kyong-Mi, Sun, Yan V, Joseph, Jacob, Leach, Andrew R, Edwards, Todd L, Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S, Casas, Juan P, Casas

Volltext