A Model for Human Cytochrome P450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding von Modi, S, Paine, M. J, Sutcliffe, M. J, Lian, L.-Y, Primrose, W. U, Wolf, C. R, Roberts, G. C. K

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6:  Allosteric Effects of NADPH−Cytochrome P450 Reductase von Modi, S, Gilham, D. E, Sutcliffe, M. J, Lian, L.-Y, Primrose, W. U, Wolf, C. R, Roberts, G. C. K

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2-Hydroxyethyl-alpha-D-glucopyranoside-2,3',4'-trisphosphate, a novel, metabolically resistant, adenophostin A and myo-inositol-1,4,5-trisphosphate analogue, potently interacts wit... von Wilcox, R A, Erneux, C, Primrose, W U, Gigg, R, Nahorski, S R

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New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor von Wilcox, Robert A, Primrose, William U, Nahorski, Stefan R, Challiss, R.A.John

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Changes in the structure of bovine phospholipase A2 upon micelle binding von Kilby, P M, Primrose, W U, Roberts, G C

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A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation von Oliver, Catherine F, Modi, Sandeep, Sutcliffe, Michael J, Primrose, William U, Lian, Lu-Yun, Roberts, Gordon C. K

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A Model for Human Cytochrome P 450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding von Modi, S., Paine, M. J., Sutcliffe, M. J., Lian, L.-Y., Primrose, W. U., Wolf, C. R., Roberts, G. C. K.

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Design and synthesis of some substrate analog inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor... von Bennion, Colin, Connolly, Stephen, Gensmantel, Nigel P, Hallam, Catherine, Jackson, Clive G, Primrose, William U, Roberts, Gordon C. K, Robinson, David H, Slaich, Pritpal K

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Equilibrium and kinetic studies of substrate binding to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli von Bermingham, A, Bottomley, J R, Primrose, W U, Derrick, J P

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Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds von Oliver, C F, Modi, S, Primrose, W U, Lian, L Y, Roberts, G C

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The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction von Modi, Sandeep, Sutcliffe, Michael J., Primrose, William U., Lian, Lu-Yun, Roberts, Gordon C.K.

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Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity von Modi, S, Primrose, W U, Lian, L Y, Roberts, G C

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NMR Studies of Substrate Binding to Cytochrome P450 BM3: Comparisons to Cytochrome P450 cam von Modi, Sandeep, Primrose, William U, Boyle, James M. B, Gibson, Catherine F, Lian, Lu-Yun, Roberts, Gordon C. K

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13C NMR study of the ionizations within a trypsin-chloromethyl ketone inhibitor complex von MALTHOUSE, J. P. G, PRIMROSE, W. U, MACKENZIE, N. E, SCOTT, A. I

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The binding of amide substrate analogues to phospholipase A2 : studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy von SLAICH, P. K, PRIMROSE, W. U, ROBINSON, D. H, WHARTON, C. W, WHITE, A. J, DRABBLE, K, ROBERTS, G. C. K

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Crystallization and Preliminary X-Ray Diffraction Studies of Human Cytochrome P450 Reductase von Zhao, Qiang, Smith, Graeme, Modi, Sandeep, Paine, Mark, Wolf, Roland C., Tew, David, Lian, Lu-Yun, Primrose, William U., Roberts, Gordon C.K., Driessen, Huub P.C.

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Synthesis of a tritium labelled phospholipase A2 inhibitor: A ligand for macromolecular 3H NMR spectroscopy von Culf, A. S., Morimoto, H., Williams, P. G., Lockley, W. J. S., Primrose, W. U., Jones, J. R.

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Inhibitors of phosphopantetheine adenylyltransferase von Zhao, Lihua, Allanson, Nigel M., Thomson, Samantha P., Maclean, John K.F., Barker, John J., Primrose, William U., Tyler, Paul D., Lewendon, Ann

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1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution von FISHER, J, PRIMROSE, W. U, ROBERTS, G. C. K, DEKKER, N, BOELENS, R, KAPTEIN, R, SLOTBOOM, A. J

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Proton NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution von Fisher, J, Primrose, W. U, Roberts, G. C. K, Dekker, N, Boelens, R, Kaptein, R, Slotboom, A. J

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