Discovery of IDO1 Inhibitors: From Bench to Bedside von Prendergast, George C, Malachowski, William P, DuHadaway, James B, Muller, Alexander J

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Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond von Muller, Alexander J., Manfredi, Mark G., Zakharia, Yousef, Prendergast, George C.

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Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment von Thomas, Sunil, Mercogliano, Giancarlo, Prendergast, George C

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Gut-brain connections in neurodegenerative disease: immunotherapeutic targeting of Bin1 in inflammatory bowel disease and Alzheimer's disease von Thomas, Sunil, Prendergast, George C

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Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis von Thomas, Sunil, Dilbarov, Nickey, Kelly, Joseph, Mercogliano, Giancarlo, Prendergast, George C.

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CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion von Jiao, Xuanmao, Velasco-Velázquez, Marco A, Wang, Min, Li, Zhiping, Rui, Hallgeir, Peck, Amy R, Korkola, James E, Chen, Xuelian, Xu, Shaohua, DuHadaway, James B, Guerrero-Rodriguez, Sandra, Addya, Sankar, Sicoli, Daniela, Mu, Zhaomei, Zhang, Gang, Stucky, Andres, Zhang, Xi, Cristofanilli, Massimo, Fatatis, Alessandro, Gray, Joe W, Zhong, Jiang F, Prendergast, George C, Pestell, Richard G

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IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation von Muller, Alexander J, Mondal, Arpita, Dey, Souvik, Prendergast, George C

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Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses von Merlo, Lauren M F, DuHadaway, James B, Montgomery, James D, Peng, Wei-Dan, Murray, Peter J, Prendergast, George C, Caton, Andrew J, Muller, Alexander J, Mandik-Nayak, Laura

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IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan von Metz, Richard, Rust, Sonja, DuHadaway, James B., Mautino, Mario R., Munn, David H., Vahanian, Nicholas N., Link, Charles J., Prendergast, George C.

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Amino acid catabolism: a pivotal regulator of innate and adaptive immunity von McGaha, Tracy L., Huang, Lei, Lemos, Henrique, Metz, Richard, Mautino, Mario, Prendergast, George C., Mellor, Andrew L.

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Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer von Fox, Eric, Oliver, Thomas, Rowe, Melissa, Thomas, Sunil, Zakharia, Yousef, Gilman, Paul B, Muller, Alexander J, Prendergast, George C

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The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism von Merlo, Lauren M F, Peng, Weidan, DuHadaway, James B, Montgomery, James D, Prendergast, George C, Muller, Alexander J, Mandik-Nayak, Laura

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IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation von Metz, Richard, Smith, Courtney, DuHadaway, James B, Chandler, Phillip, Baban, Babak, Merlo, Lauren M F, Pigott, Elizabeth, Keough, Martin P, Rust, Sonja, Mellor, Andrew L, Mandik-Nayak, Laura, Muller, Alexander J, Prendergast, George C

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IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis von Merlo, Lauren M F, Pigott, Elizabeth, DuHadaway, James B, Grabler, Samantha, Metz, Richard, Prendergast, George C, Mandik-Nayak, Laura

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Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan von METZ, Richard, DUHADAWAY, James B, KAMASANI, Uma, LAURY-KLEINTOP, Lisa, MUTTER, Alexander J, PRENDERGAST, George C

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IDO is a nodal pathogenic driver of lung cancer and metastasis development von Smith, Courtney, Chang, Mee Young, Parker, Katherine H, Beury, Daniel W, DuHadaway, James B, Flick, Hollie E, Boulden, Janette, Sutanto-Ward, Erika, Soler, Alejandro Peralta, Laury-Kleintop, Lisa D, Mandik-Nayak, Laura, Metz, Richard, Ostrand-Rosenberg, Suzanne, Prendergast, George C, Muller, Alexander J

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Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase von Winters, Maria, DuHadaway, James B., Pham, Khoa N., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Sheikh, Eesha, Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J., Malachowski, William P.

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Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15 von Van, Nguyen T., Zhang, Karen, Wigmore, Rachel M., Kennedy, Anne I., DaSilva, Carolina R., Huang, Jialing, Ambelil, Manju, Villagomez, Jose H., O’Connor, Gerald J., Longman, Randy S., Cao, Miao, Snook, Adam E., Platten, Michael, Kasenty, Gerard, Sigal, Luis J., Prendergast, George C., Kim, Sangwon V.

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Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS -Driven Sporadic Pancreatic Cancers von Nevler, Avinoam, Muller, Alexander J, Sutanto-Ward, Erika, DuHadaway, James B, Nagatomo, Kei, Londin, Eric, O'Hayer, Kevin, Cozzitorto, Joseph A, Lavu, Harish, Yeo, Theresa P, Curtis, Mark, Villatoro, Tatiana, Leiby, Benjamin E, Mandik-Nayak, Laura, Winter, Jordan M, Yeo, Charles J, Prendergast, George C, Brody, Jonathan R

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Cancer: Why tumours eat tryptophan von Prendergast, George C

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