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    HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials von Swerdlow, Daniel I, Dr, Preiss, David, Dr, Holmes, Michael V, PhD, Shah, Tina, PhD, Sofat, Reecha, MD, Johnson, Paul C D, PhD, Verweij, Niek, MD, Sharp, Stephen J, MSc, Giambartolomei, Claudia, MSc, Chung, Christina, MSc, Peasey, Anne, PhD, Amuzu, Antoinette, MSc, Li, KaWah, MSc, Cooper, Jackie A, MSc, Drenos, Fotios, PhD, Li, Yun R, BSc, Lowe, Gordon, Prof, Gallacher, John, PhD, Stewart, Marlene C W, PhD, Tzoulaki, Ioanna, PhD, van der A, Daphne L, PhD, Forouhi, Nita G, MRCP, Onland-Moret, N Charlotte, PhD, Schnabel, Renate B, MD, Hubacek, Jaroslav A, PhD, Kubinova, Ruzena, MD, Baceviciene, Migle, MD, Tamosiunas, Abdonas, Prof, Topor-Madry, Romanvan, MD, Stepaniak, Urszula, PhD, Malyutina, Sofia, Prof, Baldassarre, Damiano, PhD, Sennblad, Bengt, PhD, Tremoli, Elena, Prof, Veglia, Fabrizio, PhD, Ford, Ian, Prof, Westendorp, Rudi G J, Prof, Algra, Ale, Prof, der Zee, Anke H Maitland-van, PhD, Eaton, Charles B, Prof, Robinson, Jennifer G, Prof, Duggan, David, PhD, Downs, John R, MD, Gotto, Antonio M, MD, Keech, Anthony C, MD, Marchioli, Roberto, MD, Tognoni, Gianni, MD, Sever, Peter S, Prof, Waters, David D, MD, Pedersen, Terje R, MD, Nakamura, Haruo, MD, McMurray, John J V, Prof, Lewsey, James D, PhD, Chasman, Daniel I, PhD, Ridker, Paul M, MD, Maggioni, Aldo P, Prof, Tavazzi, Luigi, Prof, Manson, JoAnn E, Prof, Price, Jackie F, MD, Whincup, Peter H, Prof, Morris, Richard W, Prof, Lawlor, Debbie A, Prof, Ben-Shlomo, Yoav, Prof, Schreiner, Pamela J, Prof, Fornage, Myriam, Prof, Siscovick, David S, Prof, Cushman, Mary, MD, Kumari, Meena, PhD, Verschuren, W M Monique, PhD, Redline, Susan, Prof, Patel, Sanjay R, MD, Whittaker, John C, Prof, Hamsten, Anders, Prof, Delaney, Joseph A, PhD, Dale, Caroline, PhD, Gaunt, Tom R, PhD, Wong, Andrew, PhD, Hardy, Rebecca, Prof, Kathiresan, Sekar, MD, Castillo, Berta A, PhD, van der Harst, Pim, Prof, Brunner, Eric J, Prof, Tybjaerg-Hansen, Anne, Prof, Krauss, Ronald M, MD, Tsai, Michael, Prof, Coresh, Josef, Prof, Psaty, Bruce M, Prof, Hakonarson, Hakon, Prof, Dudbridge, Frank, PhD, Humphries, Steve E, Prof, Timpson, Nicholas J, PhD, Langenberg, Claudia, MD, Asselbergs, Folkert W, MD, Voevoda, Mikhail, Prof, Bobak, Martin, Prof, Pikhart, Hynek, PhD, Reiner, Alex P, Prof, Keating, Brendan J, PhD, Hingorani, Aroon D, Prof, Sattar, Naveed, Prof

    Veröffentlicht in The Lancet (British edition)

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    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 von Schmidt, Amand F, Swerdlow, Daniel I, Denaxas, Spiros, Faraway, Rupert, Finan, Chris, Fairhurst-Hunter, Zammy, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, Van Iperen, Erik, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Welch, Catherine, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N. Charlotte, Van Der Schouw, Yvonne T, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Scott, Robert A, Bobak, Martin, Malyutina, Sofia, Grarup, Niels, Humphries, Steve E, Brilliant, Murray, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, De Andrade, Mariza, Denny, Joshua C, Carty, Cara, Hancock, Stephen, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Van Der Harst, Pim, Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, D. O, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Völzke, Henry, Meade, Tom, Maitland-Van Der Zee, Anke H, Ford, Ian, Campbell, Archie, Froguel, Philippe, Thuillier, Dorothée, Bonnefond, Amélie, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Reiner, Alex P, Dobbins, Sara E, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Casas, Juan P


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    PCSK9 genetic variants and risk of type 2 diabetes: A mendelian randomisation study von Schmidt, Amand F, Holmes, Michael V, Fairhurst-Hunter, Zammy, Lyall, Donald M, Hartwig, Fernando Pires, Horta, Bernardo Lessa, Hyppönen, Elina, Power, Christine, Moldovan, Max, van Iperen, Erik, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Liu, Tian, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Onland-Moret, N. Charlotte, van der Schouw, Yvonne T, Matullo, Giuseppe, Guarrera, Simonetta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert, Malyutina, Sofia, Pajak, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Husemoen, Lise Lotte Nystrup, Grarup, Niels, Linneberg, Allan, Simonsen, Kenneth Starup, Humphries, Steve E, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Crosslin, David R, de Andrade, Mariza, Roden, Dan M, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, Donnell, Martin O, Yusuf, Salim, Chong, Michael, Said, M. Abdullah, Verweij, Niek, Snieder, Harold, Mook-Kanamori, Dennis O, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Franco, Oscar, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M, Völzke, Henry, Ward, Joey, Pell, Jill P, Smith, Daniel J, Maitland-van der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Froguel, Philippe, Thuillier, Dorothée, Balkau, Beverley, Cariou, Bertrand, Smart, Melissa, Kumari, Meena, Mahajan, Anubha, Ridker, Paul M, Reiner, Alex P, Lange, Leslie A, Ritchie, Marylyn D, Asselbergs, Folkert W, Casas, Juan Pablo, Keating, Brendan J, Preiss, David, Sattar, Naveed


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    PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study von Schmidt, Amand F, Holmes, Michael V, Fairhurst-Hunter, Zammy, Lyall, Donald M, Hartwig, Fernando Pires, Power, Christine, Moldovan, Max, van Iperen, Erik, Hovingh, G Kees, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Liu, Tian, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, van der Schouw, Yvonne T, Matullo, Giuseppe, Guarrera, Simonetta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert, Malyutina, Sofia, Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Husemoen, Lise Lotte Nystrup, Grarup, Niels, Linneberg, Allan, Simonsen, Kenneth Starup, Humphries, Steve E, Carrell, David S, McCarty, Catherine A, Crosslin, David R, de Andrade, Mariza, Roden, Dan M, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Said, M Abdullah, Verweij, Niek, Snieder, Harold, LifeLines Cohort study group, Christen, Tim, Mook-Kanamori, Dennis O, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Dörr, Marcus, Lerch, Markus M, Völker, Uwe, Ward, Joey, Pell, Jill P, Meade, Tom, Maitland-van der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Thuillier, Dorothée, Balkau, Beverley, Bonnefond, Amélie, Cariou, Bertrand, Smart, Melissa, Bao, Yanchun, Kumari, Meena, Mahajan, Anubha, Chasman, Daniel I, Ritchie, Marylyn D, Casas, Juan-Pablo, Preiss, David, Hingorani, Aroon D, Sattar, Naveed


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    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 von Schmidt, Amand F, Swerdlow, Daniel I, Denaxas, Spiros, Faraway, Rupert, Finan, Chris, Fairhurst-Hunter, Zammy, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, van Iperen, Erik, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Welch, Catherine, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N. Charlotte, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Scott, Robert A, Luan, Jian’an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Grarup, Niels, Humphries, Steve E, Brilliant, Murray, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Yusuf, Salim, Chong, Michael, van der Harst, Pim, Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, D. O, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Völzke, Henry, Meade, Tom, Maitland-van der Zee, Anke H, Ford, Ian, Campbell, Archie, Froguel, Philippe, Thuillier, Dorothée, Bonnefond, Amélie, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Reiner, Alex P, Dobbins, Sara E, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Casas, Juan P

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    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 von Schmidt, Amand F, Swerdlow, Daniel I, Denaxas, Spiros, Faraway, Rupert, Finan, Chris, Fairhurst-Hunter, Zammy, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, van Iperen, Erik, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Welch, Catherine, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N Charlotte, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Scott, Robert A, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Grarup, Niels, Humphries, Steve E, Brilliant, Murray, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Denny, Joshua C, Carty, Cara, Hancock, Stephen, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, van der Harst, Pim, Verweij, Niek, Snieder, Harold, Lifelines Cohort authors, Mook-Kanamori, DO, ICBP Consortium, Ingelsson, Erik, Pazoki, Raha, Hofman, Albert, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M, Völker, Uwe, Völzke, Henry, Pell, Jill P, Christophersen, Ingrid E, Baranova, Ekaterina V, Young, Robin, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Roussel, Ronan, Bonnefond, Amélie, Cariou, Bertrand, Bao, Yanchun, METASTROKE Consortium of the ISGC, Dale, Caroline, Costa, Rui Providencia E, Chasman, Daniel I, Reiner, Alex P, Lange, Leslie A, Dobbins, Sara E, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Speedy, Helen, Allan, James, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Goldschmidt, Hartmut, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Hingorani, Aroon D

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    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 von Schmidt, Amand F, Swerdlow, Daniel I, Denaxas, Spiros, Faraway, Rupert, Finan, Chris, Fairhurst-Hunter, Zammy, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, van Iperen, Erik, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Welch, Catherine, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N. Charlotte, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Scott, Robert A, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Grarup, Niels, Humphries, Steve E, Brilliant, Murray, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Denny, Joshua C, Carty, Cara, Hancock, Stephen, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, van der Harst, Pim, Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, D. O, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Voelker, Uwe, Voelzke, Henry, Meade, Tom, Maitland-van der Zee, Anke H, Ford, Ian, Campbell, Archie, Froguel, Philippe, Thuillier, Dorothee, Bonnefond, Amelie, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Reiner, Alex P, Dobbins, Sara E, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Bjorn, Goldschmidt, Hartmut, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Casas, Juan P

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    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 von Schmidt, Amand F, Swerdlow, Daniel I, Denaxas, Spiros, Faraway, Rupert, Finan, Chris, Fairhurst-Hunter, Zammy, Hartwig, Fernando P, Horta, Bernardo L, Hypponen, Elina, Power, Christine, van Iperen, Erik, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Welch, Catherine, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N. C, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Scott, Robert A, Luan, Jian’an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Grarup, Niels, Humphries, Steve E, Brilliant, Murray, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Yusuf, Salim, Chong, Michael, van der Harst, Pim, Said, M. A, Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, D. O, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Völzke, Henry, Meade, Tom, Maitland-van der Zee, Anke H, Ford, Ian, Campbell, Archie, Froguel, Philippe, Bonnefond, Amélie, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, Dale, Caroline, Costa, Rui P E, Ridker, Paul M, Reiner, Alex P, Dobbins, Sara E, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Casas, Juan P

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