Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors von Schramme, Florence, Crosignani, Stefano, Frederix, Kim, Hoffmann, Delia, Pilotte, Luc, Stroobant, Vincent, Preillon, Julie, Driessens, Gregory, Van den Eynde, Benoit J.

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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies von Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noemie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joao R., Nyawouame, Florence, Carter, Mathew J., Baron-Bodo, Veronique, Marie-Cardine, Anne, Cragg, Mark, Dechanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

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Beyond PD-1: Investigating the Therapeutic Potential of TIGIT Blockade in DLBCL von Sunseri, Nicole, Chen, Xiufen, Wald, Noemie, Preillon, Julie, Smith, Sonali M., Driessens, Gregory, Kline, Justin

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Abstract 3249: a-TIGIT mediates antitumor activity through multiple mechanisms of action involving activation of intratumor effector T cells and depletion of regulatory T cells von Preillon, Julie, Denies, Sofie, Jamart, Diane, Carter, Matthew J., Cragg, Mark S., Driessens, Gregory

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Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile von Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory

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DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation von De Clercq, Sarah, Keruzore, Marc, Desmaris, Elodie, Pollart, Charlotte, Assimacopoulos, Stavroula, Preillon, Julie, Ascenzo, Sabrina, Matson, Clinton K, Lee, Melody, Nan, Xinsheng, Li, Meng, Nakagawa, Yasushi, Hochepied, Tino, Zarkower, David, Grove, Elizabeth A, Bellefroid, Eric J

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Abstract 4147: EOS100850, an A2Areceptor antagonist with prolonged pharmacodynamic activity, mediates the generation ofspecific durable immune responses in a murine breast cancer m... von Pirson, Romain, Michaux, Anne-Catherine, Jamart, Diane, Preillon, Julie, Frederix, Kim, Basilico, Paola, Martinoli, Chiara, Leroy, Xavier, Driessens, Gregory, Houthuys, Erica, Chappel, Scott, Crosignani, Stefano, Marillier, Reece

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Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg von LEROY, XAVIER, Hoofd, Catherine, Cuende, Julia, Denies, Sofie, Rabolli, Virginie, Preillon, Julie, Lambolez, Florence, Prasad, Shruthi, Mercier, Marjorie, Nyawouame, Florence, Bodo, Véronique, Wald, Noémie, Driessens, Grégory, Detheux, Michel

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Abstract LB-291: EOS100850, an insurmountable and non-brain penetrant A2A receptor antagonist, inhibits adenosine-mediated T cell suppression, demonstrates anti-tumor activity and... von Houthuys, Erica, Marillier, Reece, Deregnaucourt, Théo, Brouwer, margreet, Basilico, Paola, Pirson, Romain, Marchante, Joao, Prasad, Shruthi, Hermant, Annelise, Nyawouame, Florence, Preillon, Julie, Frederix, Kim, Michaux, Anne Catherine, Lambolez, Florence, Swiercz, Jakub, Driessens, Gregory, Wald, Noemie, Martinoli, Chiara, Bodo, Veronique, Detheux, Michel, Leroy, Xavier, Crosignani, Stefano

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Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors von Schramme, Florence, Crosignani, Stefano, Frederix, Kim, Hoffmann, Delia, Pilotte, Luc, Stroobant, Vincent, Preillon, Julie, Driessens, Gregory, Van den Eynde, Benoit J

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Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors von Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion

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Macrophage migration inhibitory factor in head and neck squamous cell carcinoma: clinical and experimental studies von Kindt, Nadège, Preillon, Julie, Kaltner, Herbert, Gabius, Hans-Joachim, Chevalier, Dominique, Rodriguez, Alexandra, Johnson, Bryon D., Megalizzi, Véronique, Decaestecker, Christine, Laurent, Guy, Saussez, Sven

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Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors von Tumang, Joseph, Gomes, Bruno, Wythes, Martin, Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Chaplin, Jenny, Dalvie, Deepak, Denies, Sofie, De Maeseneire, Coraline, Folger, Peter, Frederix, Kim, Guo, Jie, Hardwick, James, Hook, Ken, Jessen, Katti, Kindt, Erick, Letellier, Marie-Claire, Liao, Kai-Hsin, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Murray, Brion, Pirson, Romain, Preillon, Julie, Rabolli, Virginie, Ray, Chad, Scales, Stephanie, Srirangam, Jay, Solowiej, Jim, Streiner, Nicole, Torti, Vince, Tsaparikos, Konstantinos, Vicini, Paolo, Driessens, Gregory, Kraus, Manfred

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The Xenopus doublesex-related gene Dmrt5 is required for olfactory placode neurogenesis von Parlier, Damien, Moers, Virginie, Van Campenhout, Claude, Preillon, Julie, Leclère, Lucas, Saulnier, Amandine, Sirakov, Maria, Busengdal, Henriette, Kricha, Sadia, Marine, Jean-Christophe, Rentzsch, Fabian, Bellefroid, Eric J.

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