Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics von Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard

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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation von Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia von Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs von Mandoli, Amit, Singh, Abhishek A., Prange, Koen H.M., Tijchon, Esther, Oerlemans, Marjolein, Dirks, Rene, Ter Huurne, Menno, Wierenga, Albertus T.J., Janssen-Megens, Eva M., Berentsen, Kim, Sharifi, Nilofar, Kim, Bowon, Matarese, Filomena, Nguyen, Luan N., Hubner, Nina C., Rao, Nagesha A., van den Akker, Emile, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

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Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis von Slenders, Lotte, Landsmeer, Lennart P L, Cui, Kai, Depuydt, Marie A C, Verwer, Maarten, Mekke, Joost, Timmerman, Nathalie, van den Dungen, Noortje A M, Kuiper, Johan, de Winther, Menno P J, Prange, Koen H M, Ma, Wei Feng, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, de Borst, Gert J, de Kleijn, Dominique P V, Asselbergs, Folkert W, den Ruijter, Hester M, Boltjes, Arjan, Pasterkamp, Gerard, van der Laan, Sander W, Mokry, Michal

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The genome-wide molecular signature of transcription factors in leukemia von Prange, Koen H.M, Singh, Abhishek A, Martens, Joost H.A

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Transcriptional and epigenetic regulation of macrophages in atherosclerosis von Kuznetsova, Tatyana, Prange, Koen H. M., Glass, Christopher K., de Winther, Menno P. J.

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Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotei... von Stiekema, Lotte C A, Prange, Koen H M, Hoogeveen, Renate M, Verweij, Simone L, Kroon, Jeffrey, Schnitzler, Johan G, Dzobo, Kim E, Cupido, Arjen J, Tsimikas, Sotirios, Stroes, Erik S G, de Winther, Menno P J, Bahjat, Mahnoush

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Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques von Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow von Stiekema, Lotte C A, Willemsen, Lisa, Kaiser, Yannick, Prange, Koen H M, Wareham, Nicholas J, Boekholdt, S Matthijs, Kuijk, Carlijn, de Winther, Menno P J, Voermans, Carlijn, Nahrendorf, Matthias, Stroes, Erik S G, Kroon, Jeffrey

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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease von Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther

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Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation von Dzobo, Kim E, Cupido, Arjen J, Mol, Barend M, Stiekema, Lotte C.A, Versloot, Miranda, Winkelmeijer, Maaike, Peter, Jorge, Pennekamp, Anne Marije, Havik, Stefan R, Vaz, Frédéric M, Van Weeghel, Michel, Prange, Koen H.M, Levels, Johannes H.M, De Winther, Menno P.J, Tsimikas, Sotirios, Groen, Albert K, Stroes, Erik S.G, De Kleijn, Dominique P.V, Kroon, Jeffrey

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Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation von Dzobo, Kim E, Cupido, Arjen J, Mol, Barend M, Stiekema, Lotte C.A, Versloot, Miranda, Winkelmeijer, Maaike, Peter, Jorge, Pennekamp, Anne-Marije, Havik, Stefan R, Vaz, Frederic M, van Weeghel, Michel, Prange, Koen H.M, Levels, Johannes H.M, de Winther, Menno P.J, Tsimikas, Sotirios, Groen, Albert K, Stroes, Erik S.G, de Kleijn, Dominique P.V, Kroon, Jeffrey

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Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques von Diez Benavente, Ernest, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J G, Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M, de Borst, Gert J, de Kleijn, Dominique P V, Prange, Koen H M, Depuydt, Marie A C, de Winther, Menno P J, Kuiper, Johan, Björkegren, Johan L M, Erdmann, Jeanette, Civelek, Mete, Mokry, Michal, Owens, Gary K, Pasterkamp, Gerard, den Ruijter, Hester M

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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability von Willemsen, Lisa, Prange, Koen H M, Neele, Annette E, van Roomen, Cindy P A A, Gijbels, Marion, Griffith, Guillermo R, Toom, Myrthe den, Beckers, Linda, Siebeler, Ricky, Spann, Nathanael J, Chen, Hung-Jen, Bosmans, Laura A, Gorbatenko, Andrej, van Wouw, Suzanne, Zelcer, Noam, Jacobs, Heinz, van Leeuwen, Fred, de Winther, Menno P J

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Myeloid Kdm6b deficiency results in advanced atherosclerosis von Neele, Annette E., Gijbels, Marion J.J., van der Velden, Saskia, Hoeksema, Marten A., Boshuizen, Marieke C.S., Prange, Koen H.M., Chen, Hung-Jen, Van den Bossche, Jan, van Roomen, Cindy P.P.A., Shami, Annelie, Levels, Johannes H.M., Kroon, Jeffrey, Lucas, Tina, Dimmeler, Stefanie, Lutgens, Esther, de Winther, Menno P.J.

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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes von Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells von Depuydt, Marie A C, Schaftenaar, Frank H, Prange, Koen H M, Boltjes, Arjan, Hemme, Esmeralda, Delfos, Lucie, de Mol, Jill, de Jong, Maaike J M, Bernabé Kleijn, Mireia N A, Peeters, Judith A H M, Goncalves, Lauren, Wezel, Anouk, Smeets, Harm J, de Borst, Gert J, Foks, Amanda C, Pasterkamp, Gerard, de Winther, Menno P J, Kuiper, Johan, Bot, Ilze, Slütter, Bram

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AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis von Singh, Abhishek A, Mandoli, Amit, Prange, Koen H M, Laakso, Marko, Martens, Joost H A

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Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation von Mokry, Michal, Boltjes, Arjan, Slenders, Lotte, Bel-Bordes, Gemma, Cui, Kai, Brouwer, Eli, Mekke, Joost M., Depuydt, Marie A. C., Timmerman, Nathalie, Waissi, Farahnaz, Verwer, Maarten C., Turner, Adam W., Khan, Mohammad Daud, Hodonsky, Chani J., Diez Benavente, Ernest, Hartman, Robin J. G., van den Dungen, Noortje A. M., Lansu, Nico, Nagyova, Emilia, Prange, Koen H. M., Kovacic, Jason C., Björkegren, Johan L. M., Pavlos, Eleftherios, Andreakos, Evangelos, Schunkert, Heribert, Owens, Gary K., Monaco, Claudia, Finn, Aloke V., Virmani, Renu, Leeper, Nicholas J., de Winther, Menno P. J., Kuiper, Johan, de Borst, Gert J., Stroes, Erik S. G., Civelek, Mete, de Kleijn, Dominique P. V., den Ruijter, Hester M., Asselbergs, Folkert W., van der Laan, Sander W., Miller, Clint L., Pasterkamp, Gerard

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