Transcriptional and epigenetic regulation of macrophages in atherosclerosis von Kuznetsova, Tatyana, Prange, Koen H. M., Glass, Christopher K., de Winther, Menno P. J.

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Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques von Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan

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MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia von Prange, K H M, Mandoli, A, Kuznetsova, T, Wang, S-Y, Sotoca, A M, Marneth, A E, van der Reijden, B A, Stunnenberg, H G, Martens, J H A

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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease von Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther

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Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics von Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard

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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation von Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

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Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotei... von Stiekema, Lotte C A, Prange, Koen H M, Hoogeveen, Renate M, Verweij, Simone L, Kroon, Jeffrey, Schnitzler, Johan G, Dzobo, Kim E, Cupido, Arjen J, Tsimikas, Sotirios, Stroes, Erik S G, de Winther, Menno P J, Bahjat, Mahnoush

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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study von Otto, M, Cepek, L, Ratzka, P, Doehlinger, S, Boekhoff, I, Wiltfang, J, Irle, E, Pergande, G, Ellers-Lenz, B, Windl, O, Kretzschmar, H A, Poser, S, Prange, H

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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia von Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow von Stiekema, Lotte C A, Willemsen, Lisa, Kaiser, Yannick, Prange, Koen H M, Wareham, Nicholas J, Boekholdt, S Matthijs, Kuijk, Carlijn, de Winther, Menno P J, Voermans, Carlijn, Nahrendorf, Matthias, Stroes, Erik S G, Kroon, Jeffrey

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The oncofusion protein FUS–ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia von Sotoca, A M, Prange, K H M, Reijnders, B, Mandoli, A, Nguyen, L N, Stunnenberg, H G, Martens, J H A

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Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques von Diez Benavente, Ernest, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J G, Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M, de Borst, Gert J, de Kleijn, Dominique P V, Prange, Koen H M, Depuydt, Marie A C, de Winther, Menno P J, Kuiper, Johan, Björkegren, Johan L M, Erdmann, Jeanette, Civelek, Mete, Mokry, Michal, Owens, Gary K, Pasterkamp, Gerard, den Ruijter, Hester M

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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs von Mandoli, Amit, Singh, Abhishek A., Prange, Koen H.M., Tijchon, Esther, Oerlemans, Marjolein, Dirks, Rene, Ter Huurne, Menno, Wierenga, Albertus T.J., Janssen-Megens, Eva M., Berentsen, Kim, Sharifi, Nilofar, Kim, Bowon, Matarese, Filomena, Nguyen, Luan N., Hubner, Nina C., Rao, Nagesha A., van den Akker, Emile, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability von Willemsen, Lisa, Prange, Koen H M, Neele, Annette E, van Roomen, Cindy P A A, Gijbels, Marion, Griffith, Guillermo R, Toom, Myrthe den, Beckers, Linda, Siebeler, Ricky, Spann, Nathanael J, Chen, Hung-Jen, Bosmans, Laura A, Gorbatenko, Andrej, van Wouw, Suzanne, Zelcer, Noam, Jacobs, Heinz, van Leeuwen, Fred, de Winther, Menno P J

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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes von Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

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Myeloid Kdm6b deficiency results in advanced atherosclerosis von Neele, Annette E., Gijbels, Marion J.J., van der Velden, Saskia, Hoeksema, Marten A., Boshuizen, Marieke C.S., Prange, Koen H.M., Chen, Hung-Jen, Van den Bossche, Jan, van Roomen, Cindy P.P.A., Shami, Annelie, Levels, Johannes H.M., Kroon, Jeffrey, Lucas, Tina, Dimmeler, Stefanie, Lutgens, Esther, de Winther, Menno P.J.

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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells von Depuydt, Marie A C, Schaftenaar, Frank H, Prange, Koen H M, Boltjes, Arjan, Hemme, Esmeralda, Delfos, Lucie, de Mol, Jill, de Jong, Maaike J M, Bernabé Kleijn, Mireia N A, Peeters, Judith A H M, Goncalves, Lauren, Wezel, Anouk, Smeets, Harm J, de Borst, Gert J, Foks, Amanda C, Pasterkamp, Gerard, de Winther, Menno P J, Kuiper, Johan, Bot, Ilze, Slütter, Bram

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AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis von Singh, Abhishek A, Mandoli, Amit, Prange, Koen H M, Laakso, Marko, Martens, Joost H A

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Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections von NAU, R, SÖRGEL, F, PRANGE, H. W

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The genome-wide molecular signature of transcription factors in leukemia von Prange, Koen H.M, Singh, Abhishek A, Martens, Joost H.A

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