Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate von Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion

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Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery von Powley, Ian R., Patel, Meeta, Miles, Gareth, Pringle, Howard, Howells, Lynne, Thomas, Anne, Kettleborough, Catherine, Bryans, Justin, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin

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Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate von Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion

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An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy von Demetriou, Constantinos, Abid, Naila, Butterworth, Michael, Lezina, Larissa, Sandhu, Pavandeep, Howells, Lynne, Powley, Ian R., Pringle, James H., Sidat, Zahirah, Qassid, Omar, Purnell, Dave, Kaushik, Monika, Duckworth, Kaitlin, Hartshorn, Helen, Thomas, Anne, Shaw, Jacqui A., MacFarlane, Marion, Pritchard, Catrin, Miles, Gareth J.

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Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes von Powley, Ian R, Kondrashov, Alexander, Young, Lucy A, Dobbyn, Helen C, Hill, Kirsti, Cannell, Ian G, Stoneley, Mark, Kong, Yi-Wen, Cotes, Julia A, Smith, Graeme C M, Wek, Ron, Hayes, Christopher, Gant, Timothy W, Spriggs, Keith A, Bushell, Martin, Willis, Anne E

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The ‘complexities’ of life and death: Death receptor signalling platforms von Dickens, Laura S., Powley, Ian R., Hughes, Michelle A., MacFarlane, Marion

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Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf) von Chernova, Tatyana, Murphy, Fiona A., Galavotti, Sara, Sun, Xiao-Ming, Powley, Ian R., Grosso, Stefano, Schinwald, Anja, Zacarias-Cabeza, Joaquin, Dudek, Kate M., Dinsdale, David, Le Quesne, John, Bennett, Jonathan, Nakas, Apostolos, Greaves, Peter, Poland, Craig A., Donaldson, Ken, Bushell, Martin, Willis, Anne E., MacFarlane, Marion

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Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors von Greenhalgh, Calum J, Karekla, Ellie, Miles, Gareth J, Powley, Ian R, Costa, Catia, de Jesus, Janella, Bailey, Melanie J, Pritchard, Catrin, MacFarlane, Marion, Pringle, J. Howard, Managh, Amy J

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Development of a patient-derived explant model for prediction of drug responses in endometrial cancer von Collins, Anna, Miles, Gareth J., Powley, Ian R., Hew, Roger, Pringle, J. Howard, MacFarlane, Marion, Pritchard, Catrin, Moss, Esther L.

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Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration von May, Stephanie, Müller, Miryam, Livingstone, Callum R., Skalka, George L., Walsh, Peter J., Nixon, Colin, Hedley, Ann, Shaw, Robin, Clark, William, Vande Voorde, Johan, Officer-Jones, Leah, Ballantyne, Fiona, Powley, Ian R., Drake, Thomas M., Kiourtis, Christos, Keith, Andrew, Rocha, Ana Sofia, Tardito, Saverio, Sumpton, David, Le Quesne, John, Bushell, Martin, Sansom, Owen J., Bird, Thomas G.

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Compromised vitamin D receptor signalling in malignant melanoma is associated with tumour progression and mitogen-activated protein kinase activity von Hutchinson, Peter E, Halsall, John A, Popovici, Silvia, Papadogeorgakis, Eftychios, Osborne, Joy E, Powley, Ian R, Dasari, Deepthi, Saldanha, Gerald, Pringle, James H

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Modulation of the sensitivity of Jurkat T-cells to inhibition of protein synthesis by tumor necrosis factor α-related apoptosis-inducing ligand von Elia, Androulla, Powley, Ian R, MacFarlane, Marion, Clemens, Michael J

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Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression von Xavier, Vanessa, Martinelli, Silvia, Corbyn, Ryan, Pennie, Rachel, Rakovic, Kai, Powley, Ian R, Officer-Jones, Leah, Ruscica, Vincenzo, Galloway, Alison, Carlin, Leo M, Cowling, Victoria H, Le Quesne, John, Martinou, Jean-Claude, MacVicar, Thomas

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Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor [alpha]-Related Apoptosis-Inducing Ligand von Elia, Androulla, Powley, Ian R, MacFarlane, Marion, Clemens, Michael J

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The acomplexitiesa of life and death: Death receptor signalling platforms von Dickens, Laura S, Powley, Ian R, Hughes, Michelle A, MacFarlane, Marion

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Exploration of matrix effects in laser ablation inductively coupled plasma mass spectrometry imaging of cisplatin treated tumors von Calum Greenhalgh, Ellie Karekla, Gareth J Miles, Ian R Powley, Catia Costa, Janella de Jesus, Melanie Jane Bailey, Catrin Pritchard, Marion MacFarlane, J Howard Pringle, Amy Managh

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Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate von Fox, Joanna L, Hughes, Michelle A, Meng, Xin, Sarnowska, Nikola A, Powley, Ian R, Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J, Fairall, Louise, Schwabe, John W. R, Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion

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Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate von Fox, Joanna L, Hughes, Michelle A, Meng, Xin, Sarnowska, Nikola A, Powley, Ian R, Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J, Fairall, Louise, Schwabe, John WR, Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion

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Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf) von Chernova, Tatyana, Murphy, Fiona A, Galavotti, Sara, Sun, Xiao-Ming, Powley, Ian R, Grosso, Stefano, Schinwald, Anja, Zacarias-Cabeza, Joaquin, Dudek, Kate M, Dinsdale, David, Le Quesne, John, Bennett, Jonathan, Nakas, Apostolos, Greaves, Peter, Poland, Craig A, Donaldson, Ken, Bushell, Martin, Willis, Anne E, MacFarlane, Marion

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Abstract 666: A novel, highly selective PI3Kδ inhibitor for the treatment of solid malignancies that express high levels of target protein as assessed by immunohistochemistry von MacQueen, Amy R., Viticchie, Giuditta, Niewola, Karolina, Finotello, Francesca, Powley, Ian, Shah, Pritom, van der Veen, Lars, Lahn, Michael, Johnson, Zoe

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