Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39 von Jeffrey, Jenna L, Lawson, Kenneth V, Powers, Jay P

Volltext

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN von HONG XIAO, DAIRAGHI, Daniel J, BAO LU, GERARD, Norma P, GERARD, Craig, SCHALL, Thomas J, JAEN, Juan C, FALK, Ronald J, JENNETTE, J. Charles, POWERS, Jay P, ERTL, Linda S, BAUMGART, Trageen, YU WANG, SEITZ, Lisa C, PENFOLD, Mark E. T, LIN GAN, PEIQI HU

Volltext

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers von Seitz, Lisa, Jin, Lixia, Leleti, Manmohan, Ashok, Devika, Jeffrey, Jenna, Rieger, Aimee, Tiessen, Renger G., Arold, Gerhard, Tan, Joanne B. L., Powers, Jay P., Walters, Matthew J., Karakunnel, Joyson

Volltext

Discovery of AB680: A Potent and Selective Inhibitor of CD73 von Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P

Volltext

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evalua... von Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J

Volltext

Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity von Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J

Volltext

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73 von Beatty, Joel W, Lindsey, Erick A, Thomas-Tran, Rhiannon, Debien, Laurent, Mandal, Debashis, Jeffrey, Jenna L, Tran, Anh T, Fournier, Jeremy, Jacob, Steven D, Yan, Xuelei, Drew, Samuel L, Ginn, Elaine, Chen, Ada, Pham, Amber T, Zhao, Sharon, Jin, Lixia, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Moschütz, Susanne, Sträter, Norbert, Powers, Jay P, Lawson, Kenneth V

Volltext

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors von Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.

Volltext

Discovery of Potent and Selective PI3Kγ Inhibitors von Drew, Samuel L, Thomas-Tran, Rhiannon, Beatty, Joel W, Fournier, Jeremy, Lawson, Kenneth V, Miles, Dillon H, Mata, Guillaume, Sharif, Ehesan U, Yan, Xuelei, Mailyan, Artur K, Ginn, Elaine, Chen, Jie, Wong, Kent, Soni, Divyank, Dhanota, Puja, Chen, Pei-Yu, Shaqfeh, Stefan G, Meleza, Cesar, Pham, Amber T, Chen, Ada, Zhao, Xiaoning, Banuelos, Jesus, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

Volltext

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands von Zabel, Brian A, Wang, Yu, Lewen, Susanna, Berahovich, Robert D, Penfold, Mark E. T, Zhang, Penglie, Powers, Jay, Summers, Bretton C, Miao, Zhenhua, Zhao, Bin, Jalili, Ali, Janowska-Wieczorek, Anna, Jaen, Juan C, Schall, Thomas J

Volltext

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease von Dairaghi, Daniel J., Oyajobi, Babatunde O., Gupta, Anjana, McCluskey, Brandon, Miao, Shichang, Powers, Jay P., Seitz, Lisa C., Wang, Yu, Zeng, Yibin, Zhang, Penglie, Schall, Thomas J., Jaen, Juan C.

Volltext

Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ) von Mata, Guillaume, Miles, Dillon H, Drew, Samuel L, Fournier, Jeremy, Lawson, Kenneth V, Mailyan, Artur K, Sharif, Ehesan U, Yan, Xuelei, Beatty, Joel W, Banuelos, Jesus, Chen, Jie, Ginn, Elaine, Chen, Ada, Gerrick, Kimberline Y, Pham, Amber T, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Narasappa, Nell, Singh, Hema, Zhao, Xiaoning, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

Volltext

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice von Sullivan, Timothy, Miao, Zhenhua, Dairaghi, Daniel J, Krasinski, Antoni, Wang, Yu, Zhao, Bin N, Baumgart, Trageen, Ertl, Linda S, Pennell, Andrew, Seitz, Lisa, Powers, Jay, Zhao, Ruiping, Ungashe, Solomon, Wei, Zheng, Boring, Landin, Tsou, Chia-Lin, Charo, Israel, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

Volltext

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes von Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

Volltext

Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper von Wang, Zhulun, Liu, Jinsong, Sudom, Athena, Ayres, Merrill, Li, Shyun, Wesche, Holger, Powers, Jay P., Walker, Nigel P.C.

Volltext

Discovery of Potent and Selective 7‑Azaindole Isoindolinone-Based PI3Kγ Inhibitors von Miles, Dillon H, Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U, Drew, Samuel L, Mata, Guillaume, Lawson, Kenneth V, Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Chen, Ada, Pham, Amber T, Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J, Walker, Nigel P, Zhao, Xiaoning, Young, Stephen W, Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

Volltext

Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors von Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

Volltext

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 von Powers, Jay P., Li, Shyun, Jaen, Juan C., Liu, Jinqian, Walker, Nigel P.C., Wang, Zhulun, Wesche, Holger

Volltext

Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Precli... von Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J

Volltext

CCR9 Antagonists in the Treatment of Ulcerative Colitis von Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.

Volltext