Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam von KAITANY, Kip-Chumba J, KLINGER, Neil V, JUNE, Cynthia M, RAMEY, Maddison E, BONOMO, Robert A, POWERS, Rachel A, LEONARD, David A

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Biochemical and Structural Analysis of Inhibitors Targeting the ADC‑7 Cephalosporinase of Acinetobacter baumannii von Powers, Rachel A., Swanson, Hollister C., Taracila, Magdalena A., Florek, Nicholas W., Romagnoli, Chiara, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A., Wallar, Bradley J.

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Structural Origins of Oxacillinase Specificity in Class D β-Lactamases von JUNE, Cynthia M, VALLIER, Beth C, BONOMO, Robert A, LEONARD, David A, POWERS, Rachel A

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Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to... von Introvigne, Maria Luisa, Beardsley, Trevor J, Fernando, Micah C, Leonard, David A, Wallar, Bradley J, Rudin, Susan D, Taracila, Magdalena A, Rather, Philip N, Colquhoun, Jennifer M, Song, Shaina, Fini, Francesco, Hujer, Kristine M, Hujer, Andrea M, Prati, Fabio, Powers, Rachel A, Bonomo, Robert A, Caselli, Emilia

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Class D β‑Lactamases: A Reappraisal after Five Decades von Leonard, David A, Bonomo, Robert A, Powers, Rachel A

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Structural and Dynamic Features of Acinetobacter baumannii OXA-66 β-Lactamase Explain Its Stability and Evolution of Novel Variants von Klamer, Zachary L., June, Cynthia M., Wawrzak, Zdzislaw, Taracila, Magdalena A., Grey, Joshua A., Benn, Alyssa M.I., Russell, Christopher P., Bonomo, Robert A., Powers, Rachel A., Leonard, David A., Szarecka, Agnieszka

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Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40 von Mitchell, Joshua M., June, Cynthia M., Baggett, Vincent L., Lowe, Beth C., Ruble, James F., Bonomo, Robert A., Leonard, David A., Powers, Rachel A.

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Exploring the potential of boronic acids as inhibitors of OXA‐24/40 β‐lactamase von Werner, Josephine P., Mitchell, Joshua M., Taracila, Magdalena A., Bonomo, Robert A., Powers, Rachel A.

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Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-S... von Powers, Rachel A., June, Cynthia M., Fernando, Micah C., Fish, Erin R., Maurer, Olivia L., Baumann, Rachelle M., Beardsley, Trevor J., Taracila, Magdalena A., Rudin, Susan D., Hujer, Kristine M., Hujer, Andrea M., Santi, Nicolò, Villamil, Valentina, Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Bonomo, Robert A., Wallar, Bradley J.

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Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239 von Harper, Thomas M, June, Cynthia M, Taracila, Magdalena A, Bonomo, Robert A, Powers, Rachel A, Leonard, David A

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The structure of a doripenem‐bound OXA‐51 class D β‐lactamase variant with enhanced carbapenemase activity von June, Cynthia M., Muckenthaler, Taylor J., Schroder, Emma C., Klamer, Zachary L., Wawrzak, Zdzislaw, Powers, Rachel A., Szarecka, Agnieszka, Leonard, David A.

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Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog von Curtis, Brandy N., Smolen, Kali A., Barlow, Sara J., Caselli, Emilia, Prati, Fabio, Taracila, Magdalena A., Bonomo, Robert A., Wallar, Bradley J., Powers, Rachel A.

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Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem von Schneider, Kyle D., Ortega, Caleb J., Renck, Nicholas A., Bonomo, Robert A., Powers, Rachel A., Leonard, David A.

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A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii von Hujer, Andrea M., Hujer, Kristine M., Leonard, David A., Powers, Rachel A., Wallar, Bradley J., Mack, Andrew R., Taracila, Magdalena A., Rather, Philip N., Higgins, Paul G., Prati, Fabio, Caselli, Emilia, Marshall, Steven H., Clarke, Thomas, Greco, Christopher, Venepally, Pratap, Brinkac, Lauren, Kreiswirth, Barry N., Fouts, Derrick E., Bonomo, Robert A.

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Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D β‑Lactamases from Acinetobacter baumannii von Mitchell, Joshua M, Clasman, Jozlyn R, June, Cynthia M, Kaitany, Kip-Chumba J, LaFleur, James R, Taracila, Magdalena A, Klinger, Neil V, Bonomo, Robert A, Wymore, Troy, Szarecka, Agnieszka, Powers, Rachel A, Leonard, David A

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The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem von Schneider, Kyle D, Karpen, Mary E, Bonomo, Robert A, Leonard, David A, Powers, Rachel A

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Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase von Powers, Rachel A, Shoichet, Brian K

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1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β‑Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase von Caselli, Emilia, Fini, Francesco, Introvigne, Maria Luisa, Stucchi, Mattia, Taracila, Magdalena A, Fish, Erin R, Smolen, Kali A, Rather, Philip N, Powers, Rachel A, Wallar, Bradley J, Bonomo, Robert A, Prati, Fabio

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Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C β‑Lactamase von Bouza, Alexandra A, Swanson, Hollister C, Smolen, Kali A, VanDine, Alison L, Taracila, Magdalena A, Romagnoli, Chiara, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A, Powers, Rachel A, Wallar, Bradley J

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Structure-based efforts to optimize a non-β-lactam inhibitor of AmpC β-lactamase von Hendershot, Jenna M., Mishra, Uma J., Smart, Robert P., Schroeder, William, Powers, Rachel A.

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