Palladium(II)‐Catalyzed Site‐Selective C(sp3)−H Alkynylation of Oligopeptides: A Linchpin Approach for Oligopeptide–Drug Conjugation von Liu, Tao, Qiao, Jennifer X., Poss, Michael A., Yu, Jin‐Quan

Volltext

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials von Bloom, Steven, Liu, Chun, Kölmel, Dominik K., Qiao, Jennifer X., Zhang, Yong, Poss, Michael A., Ewing, William R., MacMillan, David W. C.

Volltext

Ligand-accelerated non-directed C–H functionalization of arenes von Wang, Peng, Verma, Pritha, Xia, Guoqin, Shi, Jun, Qiao, Jennifer X., Tao, Shiwei, Cheng, Peter T. W., Poss, Michael A., Farmer, Marcus E., Yeung, Kap-Sun, Yu, Jin-Quan

Volltext

Decarboxylative Peptide Macrocyclization through Photoredox Catalysis von McCarver, Stefan J., Qiao, Jennifer X., Carpenter, Joseph, Borzilleri, Robert M., Poss, Michael A., Eastgate, Martin D., Miller, Michael M., MacMillan, David W. C.

Volltext

A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling von Ni, Shengyang, Garrido‐Castro, Alberto F., Merchant, Rohan R., de Gruyter, Justine N., Schmitt, Daniel C., Mousseau, James J., Gallego, Gary M., Yang, Shouliang, Collins, Michael R., Qiao, Jennifer X., Yeung, Kap‐Sun, Langley, David R., Poss, Michael A., Scola, Paul M., Qin, Tian, Baran, Phil S.

Volltext

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers von Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark

Volltext

Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9) von Mussari, Christopher P, Dodd, Dharmpal S, Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L, Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L, Salter-Cid, Luisa M, Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A, Carter, Percy H, Dyckman, Alaric J

Volltext

A novel small molecule inhibitor of hepatitis C virus entry von Baldick, Carl J, Wichroski, Michael J, Pendri, Annapurna, Walsh, Ann W, Fang, Jie, Mazzucco, Charles E, Pokornowski, Kevin A, Rose, Ronald E, Eggers, Betsy J, Hsu, Mayla, Zhai, Weixu, Zhai, Guangzhi, Gerritz, Samuel W, Poss, Michael A, Meanwell, Nicholas A, Cockett, Mark I, Tenney, Daniel J

Volltext

Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation von Wu, Qing-Feng, Shen, Peng-Xiang, He, Jian, Wang, Xiao-Bing, Zhang, Forrest, Shao, Qian, Zhu, Ru-Yi, Mapelli, Claudio, Qiao, Jennifer X, Poss, Michael A, Yu, Jin-Quan

Volltext

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1) von Purandare, Ashok V., Chen, Zhong, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Oconnell, Jonathan, Nowak, Kimberly, Jayaraman, Lata

Volltext

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) von Huynh, Tram, Chen, Zhong, Pang, Suhong, Geng, Jieping, Bandiera, Tiziano, Bindi, Simona, Vianello, Paola, Roletto, Fulvia, Thieffine, Sandrine, Galvani, Arturo, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.

Volltext

Ligand-Enabled β‑C(sp3)–H Olefination of Free Carboxylic Acids von Zhuang, Zhe, Yu, Chang-Bin, Chen, Gang, Wu, Qing-Feng, Hsiao, Yi, Joe, Candice L, Qiao, Jennifer X, Poss, Michael A, Yu, Jin-Quan

Volltext

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)­p... von Qiao, Jennifer X, Wang, Tammy C, Adam, Leonard P, Chen, Alice Ye A, Taylor, David S, Yang, Richard Z, Zhuang, Shaobin, Sleph, Paul G, Li, Julia P, Li, Danshi, Yin, Xiaohong, Chang, Ming, Chen, Xue-Qing, Shen, Hong, Li, Jianqing, Smith, Daniel, Wu, Dauh-Rurng, Leith, Leslie, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Miller, Michael M, Bilder, Donna, Rampulla, Richard, Li, Yi-Xin, Xu, Carrie, Lawrence, R. Michael, Poss, Michael A, Levesque, Paul, Gordon, David A, Huang, Christine S, Finlay, Heather J, Wexler, Ruth R, Salvati, Mark E

Volltext

Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis von Palkowitz, Maximilian D., Laudadio, Gabriele, Kolb, Simon, Choi, Jin, Oderinde, Martins S., Ewing, Tamara El-Hayek, Bolduc, Philippe N., Chen, TeYu, Zhang, Hao, Cheng, Peter T. W., Zhang, Benxiang, Mandler, Michael D., Blasczak, Vanna D., Richter, Jeremy M., Collins, Michael R., Schioldager, Ryan L., Bravo, Martin, Dhar, T. G. Murali, Vokits, Benjamin, Zhu, Yeheng, Echeverria, Pierre-Georges, Poss, Michael A., Shaw, Scott A., Clementson, Sebastian, Petersen, Nadia Nasser, Mykhailiuk, Pavel K., Baran, Phil S.

Volltext

Lipidation of a bioactive cyclotide-based CXCR4 antagonist greatly improves its pharmacokinetic profile in vivo von Chaudhuri, Dipankar, Lu, Tiangong, Jacob, Binu, Abraham, Sojan, Shankar, Premlata, Poss, Michael A., Neamati, Nouri, Camarero, Julio A.

Volltext

Ligand-Enabled β‑C–H Arylation of α‑Amino Acids Using a Simple and Practical Auxiliary von Chen, Gang, Shigenari, Toshihiko, Jain, Pankaj, Zhang, Zhipeng, Jin, Zhong, He, Jian, Li, Suhua, Mapelli, Claudio, Miller, Michael M, Poss, Michael A, Scola, Paul M, Yeung, Kap-Sun, Yu, Jin-Quan

Volltext

Ligand Enabled Pd(II)-Catalyzed γ‑C(sp3)–H Lactamization of Native Amides von Liu, Shuang, Zhuang, Zhe, Qiao, Jennifer X, Yeung, Kap-Sun, Su, Shun, Cherney, Emily C, Ruan, Zheming, Ewing, William R, Poss, Michael A, Yu, Jin-Quan

Volltext

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus von Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.

Volltext

Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2:  Synthesis, X-ray Crystallographic Analysis, and Biological Activities von Kim, Kyoung Soon, Kimball, S. David, Misra, Raj N, Rawlins, David B, Hunt, John T, Xiao, Hai-Yun, Lu, Songfeng, Qian, Ligang, Han, Wen-Ching, Shan, Weifang, Mitt, Toomas, Cai, Zhen-Wei, Poss, Michael A, Zhu, Hong, Sack, John S, Tokarski, John S, Chang, Chieh Ying, Pavletich, Nikola, Kamath, Amrita, Humphreys, William G, Marathe, Punit, Bursuker, Isia, Kellar, Kristen A, Roongta, Urvashi, Batorsky, Roberta, Mulheron, Janet G, Bol, David, Fairchild, Craig R, Lee, Francis Y, Webster, Kevin R

Volltext

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase von Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.

Volltext