Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells von Ramirez, Michael, Rajaram, Satwik, Steininger, Robert J., Osipchuk, Daria, Roth, Maike A., Morinishi, Leanna S., Evans, Louise, Ji, Weiyue, Hsu, Chien-Hsiang, Thurley, Kevin, Wei, Shuguang, Zhou, Anwu, Koduru, Prasad R., Posner, Bruce A., Wu, Lani F., Altschuler, Steven J.

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Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer von Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D., White, Michael A.

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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan von Wang, Chensu, Niederstrasser, Hanspeter, Douglas, Peter M., Lin, Rueyling, Jaramillo, Juan, Li, Yang, Oswald, Nathaniel W., Zhou, Anwu, McMillan, Elizabeth A., Mendiratta, Saurabh, Wang, Zhaohui, Zhao, Tian, Lin, Zhiqaing, Luo, Min, Huang, Gang, Brekken, Rolf A., Posner, Bruce A., MacMillan, John B., Gao, Jinming, White, Michael A.

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ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression von Zhou, Huanyu, Morales, Maria Gabriela, Hashimoto, Hisayuki, Dickson, Matthew E, Song, Kunhua, Ye, Wenduo, Kim, Min S, Niederstrasser, Hanspeter, Wang, Zhaoning, Chen, Beibei, Posner, Bruce A, Bassel-Duby, Rhonda, Olson, Eric N

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TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer von Cooper, Jonathan M, Ou, Yi-Hung, McMillan, Elizabeth A, Vaden, Rachel M, Zaman, Aubhishek, Bodemann, Brian O, Makkar, Gurbani, Posner, Bruce A, White, Michael A

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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers von Tagal, Vural, Wei, Shuguang, Zhang, Wei, Brekken, Rolf A., Posner, Bruce A., Peyton, Michael, Girard, Luc, Hwang, TaeHyun, Wheeler, David A., Minna, John D., White, Michael A., Gazdar, Adi F., Roth, Michael G.

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Autosis is a Na⁺,K⁺-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia von Liu, Yang, Shoji-Kawata, Sanae, Sumpter, Rhea M., Wei, Yongjie, Ginet, Vanessa, Zhang, Liying, Posner, Bruce, Tran, Khoa A., Green, Douglas R., Xavier, Ramnik J., Shaw, Stanley Y., Clarke, Peter G. H., Puyal, Julien, Levine, Beth

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B., Frink, Robin E., Gao, Boning, Roth, Michael, Minna, John D., Daelemans, Dirk, Wistuba, Ignacio I., Posner, Bruce A., Scaglioni, Pier Paolo, White, Michael A.

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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells von Xu, Shimeng, Smothers, Jared C, Rye, Daphne, Endapally, Shreya, Chen, Hong, Li, Shili, Liang, Guosheng, Kinnebrew, Maia, Rohatgi, Rajat, Posner, Bruce A, Radhakrishnan, Arun

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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency von Tesla, Rachel, Guhl, Charlotte, Werthmann, Gordon C., Dixon, Danielle, Cenik, Basar, Addepalli, Yesu, Liang, Jue, Fass, Daniel M., Rosenthal, Zachary, Haggarty, Stephen J., Williams, Noelle S., Posner, Bruce A., Ready, Joseph M., Herz, Joachim

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A highly-sensitive high throughput assay for dynamin's basal GTPase activity von Mohanakrishnan, Aparna, Tran, Triet Vincent M, Kumar, Meera, Chen, Hong, Posner, Bruce A, Schmid, Sandra L

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HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress von Nichols, Brandt A, Oswald, Nathaniel W, McMillan, Elizabeth A, McGlynn, Kathleen, Yan, Jingsheng, Kim, Min S, Saha, Janapriya, Mallipeddi, Prema L, LaDuke, Sydnie A, Villalobos, Pamela A, Rodriguez-Canales, Jaime, Wistuba, Ignacio I, Posner, Bruce A, Davis, Anthony J, Minna, John D, MacMillan, John B, Whitehurst, Angelique W

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1,25-Dihydroxyvitamin D 3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vi... von Kjalarsdottir, Lilja, Tersey, Sarah A, Vishwanath, Mridula, Chuang, Jen-Chieh, Posner, Bruce A, Mirmira, Raghavendra G, Repa, Joyce J

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Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines von Kang, Jungseog, Hsu, Chien-Hsiang, Wu, Qi, Liu, Shanshan, Coster, Adam D, Posner, Bruce A, Altschuler, Steven J, Wu, Lani F

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Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration von Zhang, Yongyou, Desai, Amar, Yang, Sung Yeun, Bae, Ki Beom, Antczak, Monika I., Fink, Stephen P., Tiwari, Shruti, Willis, Joseph E., Williams, Noelle S., Dawson, Dawn M., Wald, David, Chen, Wei-Dong, Wang, Zhenghe, Kasturi, Lakshmi, Larusch, Gretchen A., He, Lucy, Cominelli, Fabio, Di Martino, Luca, Djuric, Zora, Milne, Ginger L., Chance, Mark, Sanabria, Juan, Dealwis, Chris, Mikkola, Debra, Naidoo, Jacinth, Wei, Shuguang, Tai, Hsin-Hsiung, Gerson, Stanton L., Ready, Joseph M., Posner, Bruce, Willson, James K. V., Markowitz, Sanford D.

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Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase von Theodoropoulos, Panayotis C, Gonzales, Stephen S, Winterton, Sarah E, Rodriguez-Navas, Carlos, McKnight, John S, Morlock, Lorraine K, Hanson, Jordan M, Cross, Bethany, Owen, Amy E, Duan, Yingli, Moreno, Jose R, Lemoff, Andrew, Mirzaei, Hamid, Posner, Bruce A, Williams, Noelle S, Ready, Joseph M, Nijhawan, Deepak

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Synthesis of the 5/5-spiroindimicin alkaloids: development of a general synthetic approach and biological investigations von Banerjee, Ankush, Brisco, Tiffany A, Ray, Sneha, Datta, Arani, Zhang, Xiaoyu, Zhang, Zhen, Busse, Alexander A, Niederstrasser, Hanspeter, Sumida, Krissty, Posner, Bruce A, Wetzel, Dawn M, Phillips, Margaret A, Smith, Myles W

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High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl‑2 Binding von Chiang, Wei-Chung, Wei, Yongjie, Kuo, Yi-Chun, Wei, Shuguang, Zhou, Anwu, Zou, Zhongju, Yehl, Jenna, Ranaghan, Matthew J, Skepner, Adam, Bittker, Joshua A, Perez, Jose R, Posner, Bruce A, Levine, Beth

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Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity von Zhang, Zhen, Ray, Sneha, Imlay, Leah, Callaghan, Lauren T, Niederstrasser, Hanspeter, Mallipeddi, Prema Latha, Posner, Bruce A, Wetzel, Dawn M, Phillips, Margaret A, Smith, Myles W

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Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase von Winterton, Sarah E, Capota, Emanuela, Wang, Xiaoyu, Chen, Hong, Mallipeddi, Prema L, Williams, Noelle S, Posner, Bruce A, Nijhawan, Deepak, Ready, Joseph M

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