OP20.08: Ovarian stroma in PCOS: relationship with circulating androgens von Fulghesu, A. M., Angioni, S., Frau, E., Milano, F., Spettu, F., Portoghese, E., Melis, G. B., Apa, R.

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ADOLESCENCE AND HYPERINSULINEMIA: IT IS ALWAYS THE FIRST STEP TOWARDS PCOS? von Fulghesu, A M, Portoghese, E, Piccaluga, M P, Spettu, F

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P143 IL-6 SERUM LEVELS AND PRODUCTION IN PCOS ADOLESCENTS IS RELATED TO INSULIN RESISTANCE von Uda, S., Fulghesu, A.M., Sanna, F., Magnini, R., Portoghese, E., Accossu, S., Contini, P.P., Batetta, B.

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INFLAMMATORY RESPONSE TO LYPOPOLYSACCHARIDE IN MONONUCLEAR CELLS FROM POLYCYSTIC OVARY SYNDROME INSULIN RESISTANT ADOLESCENTS von Fulghesu, A., Sanna, F., Uda, S., Portoghese, E., Magnini, R., Saddi, A., Batetta, B.

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A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance von Dutta, Raini, Lunzer, Mary M, Auger, Jennifer L, Akgün, Eyup, Portoghese, Philip S, Binstadt, Bryce A

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Peripherally mediated opioid combination therapy in mouse and pig von Peterson, C.D., Larson, C.M., Bruce, D.J., Clements, B.M., Pflepsen, K.R., Akgün, E., Kitto, K.F., Lunzer, M.M., Fairbanks, C.A., Portoghese, P.S., Wilcox, G.L.

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A Heterodimer-Selective Agonist Shows in vivo Relevance of G Protein-Coupled Receptor Dimers von Waldhoer, Maria, Fong, Jamie, Jones, Robert M., Lunzer, Mary M., Sharma, Shiv K., Kostenis, Evi, Portoghese, Philip S., Whistler, Jennifer L., Lifton, Richard P.

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Monfalcone, storia di un cantiere navale von Carnemolla, Stefania Elena

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FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR–DOR Heteromer von Akgün, Eyup, Lunzer, Mary M, Tian, Defeng, Ansonoff, Michael, Pintar, John, Bruce, Daniel, Hawkinson, Jon E, Wilcox, George L, Portoghese, Philip S

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Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects von Le Naour, Morgan, Lunzer, Mary M, Powers, Michael D, Kalyuzhny, Alexander E, Benneyworth, Michael A, Thomas, Mark J, Portoghese, Philip S

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Safety assessment of allylalkoxybenzene derivatives used as flavouring substances — methyl eugenol and estragole von Smith, R.L, Adams, T.B, Doull, J, Feron, V.J, Goodman, J.I, Marnett, L.J, Portoghese, P.S, Waddell, W.J, Wagner, B.M, Rogers, A.E, Caldwell, J, Sipes, I.G

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An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands von Yekkirala, Ajay S, Kalyuzhny, Alexander E, Portoghese, Philip S

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Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance von Le Naour, Morgan, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M, Powers, Mike D, Kalyuzhny, Alexander E, Portoghese, Philip S

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Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease von Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.

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N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers von Yekkirala, Ajay S, Lunzer, Mary M, McCurdy, Christopher R, Powers, Michael D, Kalyuzhny, Alexander E, Roerig, Sandra C, Portoghese, Philip S

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Benefits from using combined dynamical-statistical downscaling approaches – lessons from a case study in the Mediterranean region von Guyennon, N, Romano, E, Portoghese, I, Salerno, F, Calmanti, S, Petrangeli, A. B, Tartari, G, Copetti, D

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From Models to Molecules:  Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes von Portoghese, Philip S

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Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands von Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G, Hopson, Jessika, Powers, Michael D, Lunzer, Mary M, Miller, Laurence J, Portoghese, Philip S

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Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice von Goudie-DeAngelis, Elizabeth M., Abdelhamid, Ramy E., Nunez, Myra G., Kissel, Casey L., Kovács, Katalin J., Portoghese, Philip S., Larson, Alice A.

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A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors von Zhang, Shijun, Yekkirala, Ajay, Tang, Ye, Portoghese, Philip S.

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