ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response von Pawlikowska, P, Leray, I, de Laval, B, Guihard, S, Kumar, R, Rosselli, F, Porteu, F

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SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia von Pasmant, E, Gilbert-Dussardier, B, Petit, A, de Laval, B, Luscan, A, Gruber, A, Lapillonne, H, Deswarte, C, Goussard, P, Laurendeau, I, Uzan, B, Pflumio, F, Brizard, F, Vabres, P, Naguibvena, I, Fasola, S, Millot, F, Porteu, F, Vidaud, D, Landman-Parker, J, Ballerini, P

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B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK von Letourneux, Claire, Rocher, Géraldine, Porteu, Françoise

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Shedding of tumor necrosis factor receptors by activated human neutrophils von PORTEU, F, NATHAN, C

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Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils von PORTEU, F, HIEBLOT, C

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Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways von Garcia, Josefina, de Gunzburg, Jean, Eychène, Alain, Gisselbrecht, Sylvie, Porteu, Françoise

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Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway von Rouyez, Marie-Christine, Boucheron, Christine, Gisselbrecht, Sylvie, Dusanter-Fourt, Isabelle, Porteu, Françoise

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HETEROCHROMATIN CHANGES IN HSCS FROM CMML PATIENTS CONFER SENSITIVITY TO THE COMBINATION OF G9A/GLP INHIBITORS AND DNA HYPOMETHYLATING AGENTS VIA DEREPRESSION OF RETROELEMENTS von Hidaoui, D., Alcazer, V., Chelbi, R., Droin, N., Depil, S., Elvira-Matelot, E., Solary, E., Porteu, F.

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Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution: IMPROVING THE CLONAL EVOLUTION MODEL: THE CASE OF CMML von Laplane, L., Selimoglu-Buet, D., Renneville, A., Willekens, C., Droin, N., Porteu, F., Perie, L., Solary, E.

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Mutation in RAP1 is a rare event in myelodysplastic syndromes von CYAN, E, FREW, M, BOWEN, D, BELDJORD, C, PREUDHOMME, C, LACOMBE, C, MAYEUX, P, DREYFUS, F, PORTEU, F, FONTENAY, M

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Topic: AS04-MDS Biology and Pathogenesis/AS04a-Normal, MDS, and leukemic stem cells: CALPROTECTIN (S100A8/A9) EFFECTS ON HEALTHY CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS ARE A... von Marchand, V., Laplane, L., Valensi, L., Boutonnet, H., Selimoglu-Buet, D., Plo, I., Renneville, A., Elvira-Matelot, E., Porteu, F., Droin, N., Fontenay, M., Solary, E.

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Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding... von Porteu, F, Brockhaus, M, Wallach, D, Engelmann, H, Nathan, C F

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Reply to 'hRap1B-retro: a novel human processed Rap1B gene blurs the picture?' by Zemojtel et al von Gyan, E, Porteu, F, Fontenay, M

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Topic: AS04-MDS Biology and Pathogenesis/AS04i-Microenvironment and stem cell niche: MESENCHYMAL STROMAL CELLS OF THE BONE MARROW NICHE CONTRIBUTE TO THE PROINFLAMMATORY PHENOTYPE... von Marchand, V., Jego, C., Valensi, L., Fenaux, P., Itzykson, R., Willekens, C., Thépot, S., Berthon, C., Braun, T., Etienne, G., Selimoglu-Buet, D., Renneville, A., Elvira-Matelot, E., Porteu, F., Droin, N., Laplane, L., Solary, E.

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Topic: AS04-MDS Biology and Pathogenesis/AS04f-Gene expression profiling: CMML PATIENTS WITH LOW EXPRESSION OF TP53 POINT TO AML TRANSFORMATION von Imanci, A., Laplane, L., Selimoglu-Buet, D., Morabito, M., Francillette, M., Bouchra, B., Wagner-Ballon, O., Thépot, S., Porteu, F., Fenaux, P., Figueroa, M., Itzykson, R., Solary, E., Droin, N.

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Topic: AS04-MDS Biology and Pathogenesis/AS04h-Immune deregulation/inflammation: CXCL8 SECRETED BY IMMATURE GRANULOCYTES INHIBITS WILD-TYPE STEM AND PROGENITOR CELL EXPANSION IN CH... von Deschamps, P., Gosseye, A., Morabito, M., Imanci, A., Marchand, V., Patnaik, M., Badaoui, B., Braun, T., Berthon, C., Willekens, C., Itzykson, R., Wagner-Ballon, O., Thépot, S., Fenaux, P., Porteu, F., Droin, N., Laplane, L., Solary, E., Selimoglu-Buet, D.

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Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropo... von Porteu, Françoise, Rouyez, Marie-Christine, Cocault, Laurence, Bénit, Laurence, Charon, Martine, Picard, Françoise, Gisselbrecht, Sylvie, Souyri, Michèle, Dusanter-Fourt, Isabelle

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C034 Biological factors of response to erythropoiesis-stimulating agents in low/int-1 grade MDS von Pawlikowska, P, Kosmider, O, Park, S, Bardet, V, Kuhnowsky, F, Pierre-Eugene, C, Picard, F, Viallon, V, Viguie, F, Mayeux, P, Lacombe, C, Porteu, F, Dreyfus, F, Fontenay, M

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IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation von Garcia, Josefina, Ye, Yunbin, Arranz, Valérie, Letourneux, Claire, Pezeron, Guillaume, Porteu, Françoise

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Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation von Hamelin, Virginie, Letourneux, Claire, Romeo, Paul-Henri, Porteu, Françoise, Gaudry, Murielle

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