Reinfusion-drains reduce blood transfusions in total joint arthroplasty von Galasso, O, Castioni, D, Mercurio, M, Sticozzi, M, Porco, E, De Gori, M, Gasparini, G

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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus von Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, Cowen, Leah E.

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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling von Shaashua, Lee, Ben-Shmuel, Aviad, Pevsner-Fischer, Meirav, Friedman, Gil, Levi-Galibov, Oshrat, Nandakumar, Subhiksha, Barki, Debra, Nevo, Reinat, Brown, Lauren E., Zhang, Wenhan, Stein, Yaniv, Lior, Chen, Kim, Han Sang, Bojmar, Linda, Jarnagin, William R., Lecomte, Nicolas, Mayer, Shimrit, Stok, Roni, Bishara, Hend, Hamodi, Rawand, Levy-Lahad, Ephrat, Golan, Talia, Porco, John A., Iacobuzio-Donahue, Christine A., Schultz, Nikolaus, Tuveson, David A., Lyden, David, Kelsen, David, Scherz-Shouval, Ruth

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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris von Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer von Wolfe, Andrew L., Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K., Sanghvi, Viraj R., Mavrakis, Konstantinos J., Jiang, Man, Roderick, Justine E., Van der Meulen, Joni, Schatz, Jonathan H., Rodrigo, Christina M., Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A., Speleman, Frank, Porco, John A., Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma von Chan, Karina, Robert, Francis, Oertlin, Christian, Kapeller-Libermann, Dana, Avizonis, Daina, Gutierrez, Johana, Handly-Santana, Abram, Doubrovin, Mikhail, Park, Julia, Schoepfer, Christina, Da Silva, Brandon, Yao, Melissa, Gorton, Faith, Shi, Junwei, Thomas, Craig J., Brown, Lauren E., Porco, John A., Pollak, Michael, Larsson, Ola, Pelletier, Jerry, Chio, Iok In Christine

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma von Volegova, Marina P., Brown, Lauren E., Banerjee, Ushashi, Dries, Ruben, Sharma, Bandana, Kennedy, Alyssa, Porco, John A., George, Rani E.

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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F von Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, O’Connor, Patrick B.F., Robert, Francis, Devine, William G., Selznick, Asher, Henkel, Thomas, Merrick, William C., Brown, Lauren E., Baranov, Pavel V., Porco, John A., Pelletier, Jerry

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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors von Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, Devine, William G., Beglov, Dmitri, Henkel, Thomas, Brown, Lauren E., Vajda, Sandor, Porco, John A., Pelletier, Jerry

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Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa von Keenan, Jeremy D, Bailey, Robin L, West, Sheila K, Arzika, Ahmed M, Hart, John, Weaver, Jerusha, Kalua, Khumbo, Mrango, Zakayo, Ray, Kathryn J, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S, Emerson, Paul M, Porco, Travis C, Lietman, Thomas M

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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML von Nishida, Yuki, Zhao, Ran, Heese, Lauren E., Akiyama, Hiroki, Patel, Shreya, Jaeger, Alex M., Jacamo, Rodrigo O., Kojima, Kensuke, Ma, Man Chun John, Ruvolo, Vivian R., Chachad, Dhruv, Devine, William, Lindquist, Susan, Davis, R. Eric, Porco, John A., Whitesell, Luke, Andreeff, Michael, Ishizawa, Jo

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Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas von Zhang, Xuan, Bi, Chengfeng, Lu, Ting, Zhang, Weiwei, Yue, Ting, Wang, Cheng, Tian, Tian, Zhang, Xiaoyan, Huang, Yuhua, Lunning, Matthew, Hao, Xinbao, Brown, Lauren E., Devine, William G., Vose, Julie, Porco, John A., Fu, Kai

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Gut microbiome alteration in MORDOR I: a community-randomized trial of mass azithromycin distribution von Doan, T., Hinterwirth, A., Worden, L., Arzika, A. M., Maliki, R., Abdou, A., Kane, S., Zhong, L., Cummings, M. E., Sakar, S., Chen, C., Cook, C., Lebas, E., Chow, E. D., Nachamkin, I., Porco, T. C., Keenan, J. D., Lietman, T. M.

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Cassini Observes the Active South Pole of Enceladus von Porco, C. C, Helfenstein, P, Thomas, P. C, Ingersoll, A. P, Wisdom, J, West, R, Neukum, G, Denk, T, Wagner, R, Roatsch, T, Kieffer, S, Turtle, E, McEwen, A, Johnson, T. V, Rathbun, J, Veverka, J, Wilson, D, Perry, J, Spitale, J, Brahic, A, Burns, J. A, DelGenio, A. D, Dones, L, Murray, C. D, Squyres, S

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Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited‐State Intramolecular Proton‐Transfer Photocycloaddition von Wang, Wenyu, Clay, Anthony, Krishnan, Retheesh, Lajkiewicz, Neil J., Brown, Lauren E., Sivaguru, Jayaraman, Porco, John A.

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Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris von Iyer, Kali R, Whitesell, Luke, Porco, Jr, John A, Henkel, Thomas, Brown, Lauren E, Robbins, Nicole, Cowen, Leah E

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Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation von Itoua Maïga, Rayelle, Cencic, Regina, Chu, Jennifer, Waller, Daniel D., Brown, Lauren E., Devine, William G., Zhang, Wenhan, Sebag, Michael, Porco Jr, John A., Pelletier, Jerry

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Divergent, C–C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates von Xu, Wenqing, Brown, Lauren E, Porco, John A

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Mass azithromycin distribution for hyperendemic trachoma following a cluster-randomized trial: A continuation study of randomly reassigned subclusters (TANA II) von Keenan, Jeremy D, Tadesse, Zerihun, Gebresillasie, Sintayehu, Shiferaw, Ayalew, Zerihun, Mulat, Emerson, Paul M, Callahan, Kelly, Cotter, Sun Y, Stoller, Nicole E, Porco, Travis C, Oldenburg, Catherine E, Lietman, Thomas M

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Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis von Keiser, Patrick T., Zhang, Wenhan, Ricca, Michael, Wacquiez, Alan, Grimins, Autumn, Cencic, Regina, Patten, J.J., Shah, Pranav, Padilha, Elias, Connor, John H., Pelletier, Jerry, Lyons, Shawn M., Saeed, Mohsan, Brown, Lauren E., Porco, John A., Davey, Robert A.

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