Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases von Gingipalli, Lakshmaiah, Block, Michael H., Bao, Larry, Cooke, Emma, Dakin, Les A., Denz, Christopher R., Ferguson, Andrew D., Johannes, Jeffrey W., Larsen, Nicholas A., Lyne, Paul D., Pontz, Timothy W., Wang, Tao, Wu, Xiaoyun, Wu, Allan, Zhang, Hai-Jun, Zheng, Xiaolan, Dowling, James E., Lamb, Michelle L.

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Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology von Johannes, Jeffrey W, Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A, Dishington, Allan P, Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L, Holmes, Jane L, Howard, Tina, Huang, Jian, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, Ogg, Derek, Patel, Anil, Pike, Kurt G, Pontz, Timothy, Robb, Graeme R, Su, Nancy, Wang, Haiyun, Wu, Xiaoyun, Zhang, Hai-Jun, Zhang, Yue, Zheng, Xiaolan, Wang, Tao

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Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo von Dowling, James E, Alimzhanov, Marat, Bao, Larry, Block, Michael H, Chuaqui, Claudio, Cooke, Emma L, Denz, Christopher R, Hird, Alex, Huang, Shan, Larsen, Nicholas A, Peng, Bo, Pontz, Timothy W, Rivard-Costa, Caroline, Saeh, Jamal Carlos, Thakur, Kumar, Ye, Qing, Zhang, Tao, Lyne, Paul D

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Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibito... von Theoclitou, Maria-Elena, Aquila, Brian, Block, Michael H, Brassil, Patrick J, Castriotta, Lillian, Code, Erin, Collins, Michael P, Davies, Audrey M, Deegan, Tracy, Ezhuthachan, Jayachandran, Filla, Sandra, Freed, Ellen, Hu, Haiqing, Huszar, Dennis, Jayaraman, Muthusamy, Lawson, Deborah, Lewis, Paula M, Nadella, Murali V. P, Oza, Vibha, Padmanilayam, Maniyan, Pontz, Timothy, Ronco, Lucienne, Russell, Daniel, Whitston, David, Zheng, Xiaolan

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Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization von Dowling, James E, Chuaqui, Claudio, Pontz, Timothy W, Lyne, Paul D, Larsen, Nicholas A, Block, Michael H, Chen, Huawei, Su, Nancy, Wu, Allan, Russell, Daniel, Pollard, Hannah, Lee, John W, Peng, Bo, Thakur, Kumar, Ye, Qing, Zhang, Tao, Brassil, Patrick, Racicot, Vicki, Bao, Larry, Denz, Christopher R, Cooke, Emma

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Role of Trace Amine in the Metathesis of Imines by CpTa(NR)Cl2 von Burland, Matthew C, Pontz, Timothy W, Meyer, Tara Y

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Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo von Dowling, James E, Alimzhanov, Marat, Bao, Larry, Chuaqui, Claudio, Denz, Christopher R, Jenkins, Emma, Larsen, Nicholas A, Lyne, Paul D, Pontz, Timothy, Ye, Qing, Holdgate, Geoff A, Snow, Lindsay, O’Connell, Nichole, Ferguson, Andrew D

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors von Vasbinder, Melissa M, Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P, Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

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Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles von Holmes, Jane L., Almeida, Lynsie, Barlaam, Bernard, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Laksmaiah, Hassall, Lorraine A., Hawkins, Janet L., Ioannidis, Stephanos, Johannes, Jeffrey W., McGuire, Thomas M., Moore, Jane E., Patel, Anil, Pike, Kurt G., Pontz, Timothy, Wu, Xiaoyun, Wang, Tao, Zhang, Hai-Jun, Zheng, Xiaolan

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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI) von JUSWINDER SINGH, CHUAQUI, Claudio E, PAPADATOS, James L, BOWES, Scott, JOSIAH, Serene, LING, Leona E, BORIACK-SJODIN, P. Ann, LEE, Wen-Cherng, PONTZ, Timothy, CORBLEY, Michael J, CHEUNG, H.-Kam, ARDUINI, Robert M, MEAD, Jonathan N, NEWMAN, Miki N

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Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2 von Casás‐Selves, Matias, Zhang, Andrew X., Dowling, James E., Hallén, Stefan, Kawatkar, Aarti, Pace, Nicholas J., Denz, Christopher R., Pontz, Timothy, Garahdaghi, Farzin, Cao, Qing, Sabirsh, Alan, Thakur, Kumar, O'Connell, Nichole, Hu, Jun, Cornella‐Taracido, Iván, Weerapana, Eranthie, Zinda, Michael, Goodnow, Robert A., Castaldi, M. Paola

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Cover Picture: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2 (ChemMedChem 12/2017) von Casás‐Selves, Matias, Zhang, Andrew X., Dowling, James E., Hallén, Stefan, Kawatkar, Aarti, Pace, Nicholas J., Denz, Christopher R., Pontz, Timothy, Garahdaghi, Farzin, Cao, Qing, Sabirsh, Alan, Thakur, Kumar, O'Connell, Nichole, Hu, Jun, Cornella‐Taracido, Iván, Weerapana, Eranthie, Zinda, Michael, Goodnow, Robert A., Castaldi, M. Paola

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Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors von Vasbinder, Melissa M., Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P., Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

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Role of Trace Amine in the Metathesis of Imines by CpTa(NR)Cl 2 von Burland, Matthew C., Pontz, Timothy W., Meyer, Tara Y.

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Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity von Lyne, Paul D., Aquila, Brian, Cook, Donald J., Dakin, Les A., Ezhuthachan, Jay, Ioannidis, Stephanos, Pontz, Timothy, Su, Mei, Ye, Qing, Zheng, Xiaolan, Block, Michael H., Cowen, Scott, Deegan, Tracy L., Lee, John W., Scott, David A., Custeau, Dominique, Drew, Lisa, Poondru, Srinivasu, Shen, Minhui, Wu, Allan

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Corrigendum to “Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)”: [Bioorg. Med. Chem. Lett. 13 (2003) 4355]... von Singh, Juswinder, Chuaqui, Claudio E., Ann Boriack-Sjodin, P., Lee, Wen-Cherng, Pontz, Timothy, Corbley, Michael J., Cheung, H.-Kam, Arduini, Robert M., Mead, Jonathan N., Newman, Miki N., Papadatos, James L., Bowes, Scott, Josiah, Serene, Ling, Leona E.

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Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI) von Singh, Juswinder, Chuaqui, Claudio E, Boriack-Sjodin, P Ann, Lee, Wen Cherng, Pontz, Timothy, Corbley, Michael J, Cheung, H-Kam, Arduini, Robert M, Mead, Jonathan N, Newman, Miki N, Papadatos, James L, Bowes, Scott, Josiah, Serene, Ling, Leona E

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Discovery and Optimization of a Novel Series of Potent Mutant B‑RafV600E Selective Kinase Inhibitors von Vasbinder, Melissa M, Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P, Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Mörtl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei

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QUINAZOLINONE DERIVATIVES HAVING B-RAF INHIBITORY ACTIVITY von AQUILA BRIAN, PONTZ TIMOTHY, LYNE PAUL

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SUBSTITUTED QUINAZOLINES WITH ANTI-CANCER ACTIVITY von PONTZ TIMOTHY, AQUILA BRIAN A, LYNE PAUL

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