Targeting tau: Clinical trials and novel therapeutic approaches von VandeVrede, Lawren, Boxer, Adam L., Polydoro, Manuela

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease von de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.

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Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology von Polydoro, Manuela, Acker, Christopher M, Duff, Karen, Castillo, Pablo E, Davies, Peter

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The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease von Crimins, Johanna L, Pooler, Amy, Polydoro, Manuela, Luebke, Jennifer I, Spires-Jones, Tara L

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Tau: From research to clinical development von Holtzman, David M, Carrillo, Maria C, Hendrix, James A, Bain, Lisa J, Catafau, Ana M, Gault, Laura M, Goedert, Michel, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Miller, David S, Ostrowitzki, Susanne, Polydoro, Manuela, Smith, Sean, Wittmann, Marion, Hutton, Michael

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Synaptic alterations in the rTg4510 mouse model of tauopathy von Kopeikina, Katherine J., Polydoro, Manuela, Tai, Hwan-Ching, Yaeger, Erich, Carlson, George A., Pitstick, Rose, Hyman, Bradley T., Spires-Jones, Tara L.

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease von Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T

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Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model von Polydoro, Manuela, Dzhala, Volodymyr I., Pooler, Amy M., Nicholls, Samantha B., McKinney, A. Patrick, Sanchez, Laura, Pitstick, Rose, Carlson, George A., Staley, Kevin J., Spires-Jones, Tara L., Hyman, Bradley T.

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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons von Sanchez, Carlos G., Acker, Christopher M., Gray, Audrey, Varadarajan, Malini, Song, Cheng, Cochran, Nadire R., Paula, Steven, Lindeman, Alicia, An, Shaojian, McAllister, Gregory, Alford, John, Reece-Hoyes, John, Russ, Carsten, Craig, Lucas, Capre, Ketthsy, Doherty, Christian, Hoffman, Gregory R., Luchansky, Sarah J., Polydoro, Manuela, Dolmetsch, Ricardo, Elwood, Fiona

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Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets von Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T

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Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation von RITTER, Cristiane, ANDRADES, Michael, DAL-PIZZOL, Felipe, FROTA, Mario Luis C, BONATTO, Fernanda, PINHO, Ricardo A, POLYDORO, Manuela, KLAMT, Fabio, PINHEIRO, Cleovaldo T. S, MENNA-BARRETO, Sérgio S, MOREIRA, José Claudio F

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Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase von Heijnen, Harry F.G., van Donselaar, Elly, Slot, Jan W., Fries, Diana M., Blachard-Fillion, Beatrice, Hodara, Roberto, Lightfoot, Richard, Polydoro, Manuela, Spielberg, Dave, Thomson, Leonor, Regan, Elizabeth A., Crapo, James, Ischiropoulos, Harry

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Haloperidol- and clozapine-induced oxidative stress in the rat brain von Polydoro, Manuela, Schröder, Nadja, Lima, Maria Noemia M., Caldana, Fábio, Laranja, Daniela C., Bromberg, Elke, Roesler, Rafael, Quevedo, João, Moreira, José Cláudio F., Dal-Pizzol, Felipe

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Effect of protein malnutrition on redox state of the hippocampus of rat von Bonatto, Fernanda, Polydoro, Manuela, Andrades, Michael Éverton, Frota, Mário Luís Conte da, Dal-Pizzol, Felipe, Rotta, Liane Nanci, Souza, Diogo Onofre, Perry, Marcos Luiz, Moreira, José Cláudio Fonseca

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αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction von Greten-Harrison, Becket, Polydoro, Manuela, Morimoto-Tomita, Megumi, Diao, Ling, Williams, Andrew M, Nie, Esther H, Makani, Sachin, Tian, Ning, Castillo, Pablo E, Buchman, Vladimir L, Chandra, Sreeganga S

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Effects of maternal protein malnutrition on oxidative markers in the young rat cortex and cerebellum von Bonatto, Fernanda, Polydoro, Manuela, Andrades, Michael Éverton, Júnior, Mário Luiz Conte da Frota, Dal-Pizzol, Felipe, Rotta, Liane Nanci, Souza, Diogo Onofre, Perry, Marcos Luiz, Moreira, José Cláudio Fonseca

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alpha beta gamma -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction von Greten-Harrison, Becket, Polydoro, Manuela, Morimoto-Tomita, Megumi, Diao, Ling, Williams, Andrew M, Nie, Esther H, Makani, Sachin, Tian, Ning, Castillo, Pablo E, Buchman, Vladimir L, Chandra, Sreeganga S

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Antioxidant effects of selegiline in oxidative stress induced by iron neonatal treatment in rats von Budni, Patrícia, de Lima, Maria Noemia Martins, Polydoro, Manuela, Moreira, José Cláudio Fonseca, Schroder, Nadja, Dal-Pizzol, Felipe

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Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy von Spires-Jones, Tara L., Friedman, Taylor, Pitstick, Rose, Polydoro, Manuela, Roe, Allyson, Carlson, George A., Hyman, Bradley T.

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Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease von Polydoro, Manuela, de Calignon, Alix, Suárez-Calvet, Marc, Sanchez, Laura, Kay, Kevin R, Nicholls, Samantha B, Roe, Allyson D, Pitstick, Rose, Carlson, George A, Gómez-Isla, Teresa, Spires-Jones, Tara L, Hyman, Bradley T

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