On the relationship between block of the cardiac Na+ channel and drug‐induced prolongation of the QRS complex von Harmer, AR, Valentin, J‐P, Pollard, CE

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An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk von Pollard, CE, Abi Gerges, N, Bridgland‐Taylor, MH, Easter, A, Hammond, TG, Valentin, J‐P

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Strategies to reduce the risk of drug‐induced QT interval prolongation: a pharmaceutical company perspective von Pollard, C E, Valentin, J‐P, Hammond, T G

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hERG subunit composition determines differential drug sensitivity von Abi‐Gerges, N, Holkham, H, Jones, EMC, Pollard, CE, Valentin, J‐P, Robertson, GA

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A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes von Lawrence, C L, Bridgland‐Taylor, M H, Pollard, C E, Hammond, T G, Valentin, J‐P

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Validation of an in vitro contractility assay using canine ventricular myocytes von Harmer, A.R., Abi-Gerges, N., Morton, M.J., Pullen, G.F., Valentin, J.P., Pollard, C.E.

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Predicting changes in cardiac myocyte contractility during early drug discovery with in vitro assays von Morton, M.J., Armstrong, D., Abi Gerges, N., Bridgland-Taylor, M., Pollard, C.E., Bowes, J., Valentin, J.-P.

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In vitro models of proarrhythmia von Lawrence, C L, Pollard, C E, Hammond, T G, Valentin, J‐P

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Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG‐encoded potassium channel von Männikkö, R, Overend, G, Perrey, C, Gavaghan, CL, Valentin, J‐P, Morten, J, Armstrong, M, Pollard, CE

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Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks von Harmer, A.R., Abi-Gerges, N., Easter, A., Woods, A., Lawrence, C.L., Small, B.G., Valentin, J.-P., Pollard, C.E.

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Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability von Easter, A., Sharp, T.H., Valentin, J.-P., Pollard, C.E.

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An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment von Davies, M R, Mistry, H B, Hussein, L, Pollard, C E, Valentin, J-P, Swinton, J, Abi-Gerges, N

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Pharmacological and electrophysiological characterization of AZSMO‐23, an activator of the hERG K+ channel von Mannikko, R, Bridgland‐Taylor, M H, Pye, H, Swallow, S, Abi‐Gerges, N, Morton, M J, Pollard, C E

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Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs von Burnham, M P, Sharpe, P M, Garner, C, Hughes, R, Pollard, C E, Bowes, J

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Use of in vitro methods to predict QT prolongation von Hammond, T.G., Pollard, C.E.

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A T-type Ca2+ current underlies low-threshold Ca2+ potentials in cells of the cat and rat lateral geniculate nucleus von Crunelli, V, Lightowler, S, Pollard, C E

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Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT von Bridgland-Taylor, M.H., Hargreaves, A.C., Easter, A., Orme, A., Henthorn, D.C., Ding, M., Davis, A.M., Small, B.G., Heapy, C.G., Abi-Gerges, N., Persson, F., Jacobson, I., Sullivan, M., Albertson, N., Hammond, T.G., Sullivan, E., Valentin, J.-P., Pollard, C.E.

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Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto‐ATPase von Crack, B.E., Pollard, C.E., Beukers, M.W., Roberts, S.M., Hunt, S.F., Ingall, A.H., McKechnie, K.C.W., IJzerman, A.P., Leff, P.

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A tutorial on model informed approaches to cardiovascular safety with focus on cardiac repolarisation von Cheung, S. Y. A., Parkinson, J., Wählby-Hamrén, U., Dota, C. D., Kragh, Å. M., Bergenholm, L., Vik, T., Collins, T., Arfvidsson, C., Pollard, C. E., Tomkinson, H. K., Hamrén, B.

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Two inward currents and the transformation of low-frequency oscillations of rat and cat thalamocortical cells von Soltesz, I, Lightowler, S, Leresche, N, Jassik‐Gerschenfeld, D, Pollard, C E, Crunelli, V

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