Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b von Stiborová, Marie, Poljaková, Jitka, Martínková, Eva, Ulrichová, Jitka, Šimánek, Vilím, Dvořák, Zdeněk, Frei, Eva

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The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells von Poljaková, Jitka, Eckschlager, Tomáš, Hraběta, Jan, Hřebačková, Jana, Smutný, Svatopluk, Frei, Eva, Martínek, Václav, Kizek, René, Stiborová, Marie

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Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12‐hydroxyelli... von Stiborová, Marie, Poljaková, Jitka, Ryšlavá, Helena, Dračínský, Martin, Eckschlager, Tomáš, Frei, Eva

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DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells von Poljaková, Jitka, Frei, Eva, Gomez, Jacobo E, Aimová, Dagmar, Eckschlager, Tomáš, Hraběta, Jan, Stiborová, Marie

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Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5 von Stiborová, Marie, Poljaková, Jitka, Martínková, Eva, Ulrichová, Jitka, Šimánek, Vilím, Dvořák, Zdeněk, Frei, Eva

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Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells von POLJAKOVÁ, JITKA, GROH, TOMÁŠ, GUDINO, ŽANETA OMANA, HRABĚTA, JAN, BOŘEK-DOHALSKÁ, LUCIE, KIZEK, RENÉ, DOKTOROVÁ, HELENA, ECKSCHLAGER, TOMÁŠ, STIBOROVÁ, MARIE

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Valproic acid overcomes hypoxia-induced resistance to apoptosis von CIPRO, ŠIMON, HŘEBAČKOVÁ, JANA, HRABĚTA, JAN, POLJAKOVÁ, JITKA, ECKSCHLAGER, TOMÁŠ

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Mechanisms of ellipticine‐mediated resistance in UKF‐NB‐4 neuroblastoma cells von Procházka, Pavel, Libra, Antonín, Zemanová, Zuzana, Hřebačková, Jana, Poljaková, Jitka, Hraběta, Jan, Bunček, Martin, Stiborová, Marie, Eckschlager, Tomáš

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Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes von Kotrbová, Vera, Aimová, Dagmar, Brezinová, Anna, Janouchová, Katerina, Poljaková, Jitka, Frei, Eva, Stiborová, Marie

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Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these Cells von Poljaková, Jitka, Eckschlager, Tomáš, Činátl, Jindřich, Kizek, René, Frei, Eva, Stiborová, Marie

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Valproic acid overcomes hypoxia-induced resistance to apoptosis von CIPRO, Simon, HREBACKOVA, Jana, HRABETA, Jan, POLJAKOVA, Jitka, ECKSCHLAGER, Tomáš

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Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study von Stiborova, Marie, Poljakova, Jitka, Mrizova, Iveta, Borek-Dohalska, Lucie, Eckschlager, Tomas, Adam, Vojtech, Kizek, Rene, Frei, Eva

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Ellipticine cytotoxicity to cancer cell lines - a comparative study von Stiborová, Marie, Poljaková, Jitka, Martínková, Eva, Bořek-Dohalská, Lucie, Eckschlager, Tomáš, Kizek, Rene, Frei, Eva

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The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide von STIBOROVA, Marie, SEJBAL, Jan, FREI, Eva, BOREK-DOHALSKA, Lucie, AIMOVA, Dagmar, POLJAKOVA, Jitka, FORSTEROVA, Kristina, RUPERTOVA, Martina, WIESNER, Jiri, HUDECEK, Jiri, WIESSLER, Manfred

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The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N 2-Oxide von Stiborová, Marie, Sejbal, Jan, Bořek-Dohalská, Lucie, Aimová, Dagmar, Poljaková, Jitka, Forsterová, Kristina, Rupertová, Martina, Wiesner, Jiří, Hudeček, Jiří, Wiessler, Manfred, Frei, Eva

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Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells von Hřebačková, Jana, Poljaková, Jitka, Eckschlager, Tomáš, Hraběta, Jan, Procházka, Pavel, Smutný, Svatopluk, Stiborová, Marie

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DNA and histone deacetylases as targets for neuroblastoma treatment von Stiborová, Marie, Poljaková, Jitka, Eckschlager, Tomáš, Kizek, Rene, Frei, Eva

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The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells von Poljaková, Jitka, Eckschlager, Tomáš, Hřebačková, Jana, Hraběta, Jan, Stiborová, Marie

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Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells von HRABETA, JAN, GROH, TOMAS, KHALIL, MOHAMED ASHRAF, POLJAKOVA, JITKA, ADAM, VOJTECH, KIZEK, RENE, UHLIK, JIRI, DOKTOROVA, HELENA, CERNA, TEREZA, FREI, EVA, STIBOROVA, MARIE, ECKSCHLAGER, TOMAS

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Oxidation of an antitumor drug ellipticine by peroxidases von Poljaková, Jitka, Forsterová, Kristina, Sulc, Miroslav, Frei, Eva, Stiborová, Marie

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