Optimizing treatment with anti-epidermal growth factor receptor drugs for patients with metastatic colorectal cancer: novel mechanisms of resistance beyond RAS von Cardone, C., Blauensteiner, B., Moreno-Viedma, V., Paul, M., Martini, G., Troiani, T., Vitiello, P., Ciardiello, D., Poliero, L., Borrelli, C., Rachiglio, A., Rizzi, D., Maiello, E., Latiano, T., Normanno, N., Sibilia, M., Ciardiello, F., Martinelli, E.

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Clinical practice use of liquid biopsy to identify RAS/BRAF mutational status in patients with metastatic colorectal cancer: A single institution experience von De Falco, V., Vitiello, P., Giunta, E., Ciardiello, D., Stefania, N., Cardone, C., Vitale, P., Zanaletti, N., Terminiello, M., Poliero, L., Borrelli, C., Caputo, V., Arrichiello, G., Mattera Iacono, V., Marrone, F., Famiglietti, V., Martinelli, E., Ciardiello, F., Troiani, T.

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Retrospective study of Regorafenib versus Trifluridine/Tipiracil efficacy in chemorefractory metastatic colorectal cancer patients: a single Italian institution real-life clinical... von Vitale, P., Zanaletti, N., Vitiello, P., martinelli, e., Ciardiello, D., De Falco, V., Giunta, E., Poliero, L., Terminiello, M., Borrelli, C., Caputo, V., Arrichiello, G., Martini, G., Stefania, N., Famiglietti, V., Cardone, C., Ciardiello, F., Troiani, T.

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Receptor tyrosine kinase dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated colorectal cancer cell lines von Vitiello, P.P., Cardone, C., Ciardiello, D., Barra, G., Matrone, N., Belli, V., Martini, G., Poliero, L., Borrelli, C., Terminiello, M., Troiani, T., Morgillo, F., Ciardiello, F., Martinelli, E.

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Combination treatment with the PARP inhibitor niraparib and chemotherapeutics in a preclinical model of KRAS/BRAF mutated colorectal cancer cell lines across the four consensus mol... von Vitiello, P.P., Cardone, C., Ciardiello, D., Belli, V., Matrone, N., Borrelli, C., Poliero, L., De Falco, V., Giunta, E.F., Vitale, P., Zanaletti, N., Tirino, G., Troiani, T., Ciardiello, F., Martinelli, E.

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Functional inhibition of TGF-β in colorectal cancer cells and its interaction with AXL receptor von Ciardiello, D., Martini, G., Matrone, N., Belli, V., Vitiello, P.P., Cardone, C., Ciaramella, V., Barra, G., Poliero, L., Borrelli, C., Troiani, T., Melisi, D., Morgillo, F., Giunta, E.F., De Falco, V., Ciardiello, F., Martinelli, E.

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AXL has a prognostic role in metastatic colorectal cancer (mCRC) and is a predictive biomarker of lack of efficacy of chemotherapy (CT) + cetuximab in RAS wild type (WT) patients (... von Cardone, C., Blauensteiner, B., Moreno-Viedma, V., Paul, M.C., Martini, G., Vitiello, P.P., Ciardiello, D., Borrelli, C., Poliero, L., Vitale, P., Zanaletti, N., Famiglietti, V., Rachiglio, A.M., Rizzi, D., Maiello, E., Latiano, T.P., Normanno, N., Sibilia, M., Ciardiello, F., Martinelli, E.

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1951P Niraparib and irinotecan combination in ATM-mutated colorectal cancer von Vitiello, P.P., Martini, G., Mele, L., Giunta, E.F., De Falco, V., Ciardiello, D., Belli, V., Cardone, C., Matrone, N., Poliero, L., Tirino, V., Selvaggi, F., Papaccio, G., Troiani, T., Desiderio, V., Ciardiello, F., Martinelli, E.

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461P Real-time PCR-based assessment of RAS/BRAF mutations in the plasma of metastatic colorectal cancer (mCRC) patients: A single institution experience von Vitiello, P.P., De Falco, V., Giunta, E.F., Ciardiello, D., Canciello, M.A., Cardone, C., Vitale, P., Zanaletti, N., Borrelli, C., Poliero, L., Terminiello, M., Arrichiello, G., Caputo, V., Martini, G., Napolitano, S., Lombardi, A., Caraglia, M., Troiani, T., Ciardiello, F., Martinelli, E.

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P-200 Bone metastases from colorectal cancer correlate with biological characteristics of primary tumors: A retrospective analysis from a single institution von Giunta, E., De Falco, V., Napolitano, S., Vitale, P., Zanaletti, N., Terminiello, M., Caputo, V., Vitiello, P., Ciardiello, D., Borrelli, C., Poliero, L., Arrichiello, G., Cardone, C., Martini, G., Martinelli, E., Ciardiello, F., Troiani, T.

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28P - GLPG 1790, a new selective EPHA2 inhibitor, is active in colorectal cancer cell lines belonging to the CMS4/mesenchymal-like subtype von Vitiello, P.P., Mele, L., Prisco, C., Cardone, C., Ciardiello, D., Poliero, L., Borrelli, C., Zanaletti, N., Vitale, P., Tirino, V., Papaccio, G., Troiani, T., Ciardiello, F., Marampon, F., Desiderio, V., Martinelli, E.

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28PGLPG 1790, a new selective EPHA2 inhibitor, is active in colorectal cancer cell lines belonging to the CMS4/mesenchymal-like subtype von Vitiello, P P, Mele, L, Prisco, C, Cardone, C, Ciardiello, D, Poliero, L, Borrelli, C, Zanaletti, N, Vitale, P, Tirino, V, Papaccio, G, Troiani, T, Ciardiello, F, Marampon, F, Desiderio, V, Martinelli, E

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GLPG 1790, a new selective EPHA2 inhibitor, is active in colorectal cancer cell lines belonging to the CMS4/mesenchymal-like subtype von Vitiello, P.P., Mele, L., Prisco, C., Cardone, C., Ciardiello, D., Poliero, L., Borrelli, C., Zanaletti, N., Vitale, P., Tirino, V., Papaccio, G., Troiani, T., Ciardiello, F., Marampon, F., Desiderio, V., Martinelli, E.

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55PSynergistic activity between niraparib and chemotherapy in colorectal cancer: Molecular determinants from a preclinical model von Vitiello, P P, Ciardiello, D, Cardone, C, Martini, G, Belli, V, Borrelli, C, Poliero, L, Arrichiello, G, De Falco, V, Giunta, E F, Terminiello, M, Troiani, T, Ciardiello, F, Martinelli, E

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Dual inhibition of TGF-β and AXL as a novel treatment for colorectal cancer von Ciardiello, D., Belli, V., Cardone, C., Vitiello, P.P., Martini, G., Poliero, L., Borrelli, C., Arrichiello, G., Ciaramella, V., Matrone, N., Barra, G., De Falco, V., Giunta, E.F., Morgillo, F., Troiani, T., Terminiello, M., Melisi, D., Ciardiello, F., Martinelli, E.

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66P - Dual inhibition of TGF-β and AXL as a novel treatment for colorectal cancer von Ciardiello, D., Belli, V., Cardone, C., Vitiello, P.P., Martini, G., Poliero, L., Borrelli, C., Arrichiello, G., Ciaramella, V., Matrone, N., Barra, G., De Falco, V., Giunta, E.F., Morgillo, F., Troiani, T., Terminiello, M., Melisi, D., Ciardiello, F., Martinelli, E.

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Synergistic activity between niraparib and chemotherapy in colorectal cancer: Molecular determinants from a preclinical model von Vitiello, P.P., Ciardiello, D., Cardone, C., Martini, G., Belli, V., Borrelli, C., Poliero, L., Arrichiello, G., De Falco, V., Giunta, E.F., Terminiello, M., Troiani, T., Ciardiello, F., Martinelli, E.

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55P - Synergistic activity between niraparib and chemotherapy in colorectal cancer: Molecular determinants from a preclinical model von Vitiello, P.P., Ciardiello, D., Cardone, C., Martini, G., Belli, V., Borrelli, C., Poliero, L., Arrichiello, G., De Falco, V., Giunta, E.F., Terminiello, M., Troiani, T., Ciardiello, F., Martinelli, E.

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66PDual inhibition of TGF-β and AXL as a novel treatment for colorectal cancer von Ciardiello, D, Belli, V, Cardone, C, Vitiello, P P, Martini, G, Poliero, L, Borrelli, C, Arrichiello, G, Ciaramella, V, Matrone, N, Barra, G, De Falco, V, Giunta, E F, Morgillo, F, Troiani, T, Terminiello, M, Melisi, D, Ciardiello, F, Martinelli, E

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P-330Retrospective study of Regorafenib versus Trifluridine/Tipiracil efficacy in chemorefractory metastatic colorectal cancer patients: a single Italian institution real-life clin... von Vitale, P, Zanaletti, N, Vitiello, P, martinelli, e, Ciardiello, D, Falco, V De, Giunta, E, Poliero, L, Terminiello, M, Borrelli, C, Caputo, V, Arrichiello, G, Martini, G, Stefania, N, Famiglietti, V, Cardone, C, Ciardiello, F, Troiani, T

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