Post-translational modifications regulate signalling by Ror1 von Kaucká, M., Krejčí, P., Plevová, K., Pavlová, Š., Procházková, J., Janovská, P., Valnohová, J., Kozubík, A., Pospíšilová, Š., Bryja, V.

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Isomerizational and conformational study of 3-fluorophenylamino-2-acetyl propenenitrile (FPAAPN) von Gatial, A., Dorotíková, S., Plevová, K., Milata, V., Prónayová, N., Matějka, P.

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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia von Malcikova, J, Stano-Kozubik, K, Tichy, B, Kantorova, B, Pavlova, S, Tom, N, Radova, L, Smardova, J, Pardy, F, Doubek, M, Brychtova, Y, Mraz, M, Plevova, K, Diviskova, E, Oltova, A, Mayer, J, Pospisilova, S, Trbusek, M

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High-quality full-length immunoglobulin profiling with unique molecular barcoding von Turchaninova, M A, Davydov, A, Britanova, O V, Shugay, M, Bikos, V, Egorov, E S, Kirgizova, V I, Merzlyak, E M, Staroverov, D B, Bolotin, D A, Mamedov, I Z, Izraelson, M, Logacheva, M D, Kladova, O, Plevova, K, Pospisilova, S, Chudakov, D M

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Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status von Kubesova, B, Pavlova, S, Malcikova, J, Kabathova, J, Radova, L, Tom, N, Tichy, B, Plevova, K, Kantorova, B, Fiedorova, K, Slavikova, M, Bystry, V, Kissova, J, Gisslinger, B, Gisslinger, H, Penka, M, Mayer, J, Kralovics, R, Pospisilova, S, Doubek, M

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Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL von Brazdilova, K, Plevova, K, Skuhrova Francova, H, Kockova, H, Borsky, M, Bikos, V, Malcikova, J, Oltova, A, Kotaskova, J, Tichy, B, Brychtova, Y, Mayer, J, Doubek, M, Pospisilova, S

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Chromothripsis – Extensive Chromosomal Rearrangements and Their Significance in Cancer von Závacká, Kristýna, Plevová, Karla, Jarošová, Marie, Pospíšilová, Šárka

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FOXO1‐RICTOR AXIS INDUCES AKT PHOSPHORYLATION DURING CLL CELL ADAPTATION TO BCR INHIBITORS: IMPLICATIONS FOR COMBINATORIAL THERAPY von Ondrisova, L., Seda, V., Hoferkova, E., Chiodin, G., Hlavac, K., Kostalova, L., Pavlasova, G. Mladonicka, Filip, D., Zeni, P. Faria, Oppelt, J., Panovska, A., Plevova, K., Pospisilova, S., Simkovic, M., Vrbacky, F., Lysak, D., Fernandes, S. M., Davids, M. S., Maiques‐Diaz, A., Charalampopoulou, S., Martin‐Subero, J. I., Brown, J. R., Doubek, M., Forconi, F., Mayer, J., Mraz, M.

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P620: DYNAMICS OF GENOMIC ABERRATIONS IN RELATION TO DISEASE ACTIVITY IN UNTREATED PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA von Navrkalova, V., Kotaskova, J., Plevova, K., Reigl, T., Valisova, M., Bohunova, M., Zenatova, M., Radova, L., Panovska, A., Pospisilova, S.

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Clinical impact of genomic analysis in children with B-acute lymphoblastic leukemia: A pilot study in Slovakia von Vaska, A, Makohusova, M, Plevova, K, Skalicka, K, Cermak, M, Chovanec, F, Fabri, O, Svec, P, Kolenova, A

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P608: DISTINCT P53 PHOSPHORYLATION PATTERNS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS ARE REFLECTED IN CIRCUMJACENT PATHWAYS’ ACTIVATION UPON DNA DAMAGE von Pesova, M., Mancikova, V., Helma, R., Pavlova, S., Hejret, V., Taus, P., Hynst, J., Plevova, K., Kotaskova, J., Malcikova, J., Pospisilova, S.

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PF363 UNDETECTABLE EXPRESSION OF WNT5A, A GENE ENCODING A ROR1 LIGAND, DEFINES MEMORY B‐CELL LIKE CHRONIC LYMPHOCYTIC LEUKEMIA von Poppová, L., Janovská, P., Alonso, S., Gonzalez, B., Dumbovic, G., Pavlová, Š., Plevová, K., Kotašková, J., Doubek, M., Brychtová, Y., Mayer, J., Bryja, V., Pospíšilová, Š.

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Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact von Baliakas, Panagiotis, Jeromin, Sabine, Iskas, Michalis, Puiggros, Anna, Plevova, Karla, Nguyen-Khac, Florence, Davis, Zadie, Rigolin, Gian Matteo, Visentin, Andrea, Xochelli, Aliki, Delgado, Julio, Baran-Marszak, Fanny, Stalika, Evangelia, Abrisqueta, Pau, Durechova, Kristina, Papaioannou, George, Eclache, Virginie, Dimou, Maria, Iliakis, Theodoros, Collado, Rosa, Doubek, Michael, Calasanz, M. Jose, Ruiz-Xiville, Neus, Moreno, Carolina, Jarosova, Marie, Leeksma, Alexander C., Panayiotidis, Panayiotis, Podgornik, Helena, Cymbalista, Florence, Anagnostopoulos, Achilles, Trentin, Livio, Stavroyianni, Niki, Davi, Fred, Ghia, Paolo, Kater, Arnon P., Cuneo, Antonio, Pospisilova, Sarka, Espinet, Blanca, Athanasiadou, Anastasia, Oscier, David, Haferlach, Claudia, Stamatopoulos, Kostas

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REFINING PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH SOMATICALLY HYPERMUTATED B-CELL RECEPTORS: A NOVEL PROGNOSTIC INDEX ON BEHALF OF THE EUROPEAN RESEARCH INITIATIVE ON CLL (ER... von Baliakas, Panagiotis, Hadzidimitriou, A., Mattsson, Mattias, Xochelli, Aliki, Sutton, L. A., Minga, E., Scarfo, L., Rossi, D., Davis, Z., Agathangelidis, A., Villamor, N., Parker, H., Kotaskova, J., Stalika, E., Plevova, K., Mansouri, Larry, Cortese, Diego, Navarro Lopez, A., Delgado, J., Larrayoz, M., Anagnostopoulos, A., Belessi, C., Smedby, K. E., Juliusson, G., Strefford, J. C., Pospisilova, S., Oscier, D., Gaidano, G., Campo, E., Ghia, P., Rosenquist, Richard, Stamatopoulos, Kostas

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Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study von Leeksma, Alexander C, Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, Van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E, Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, Van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Österborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loïc, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Strefford, Jonathan C, Mellink, Clemens, Kater, Arnon P

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Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study von Leeksma, Alexander C., Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E., Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Osterborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loic, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Strefford, Jonathan C., Mellink, Clemens, Kater, Arnon P.

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Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL von Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Gemenetzi, Katerina, Giudicelli, Veronique, Karypidou, Maria, Plevova, Karla, Davis, Zadie, Yan, Xiao-Jie, Jeromin, Sabine, Schneider, Christof, Pedersen, Lone Bredo, Tschumper, Renee C., Sutton, Lesley-Ann, Baliakas, Panagiotis, Scarfò, Lydia, van Gastel, Ellen J., Armand, Marine, Tausch, Eugen, Biderman, Bella, Baer, Constance, Bagnara, Davide, Navarro, Alba, Langlois de Septenville, Anne, Guido, Valentina, Mitterbauer-Hohendanner, Gerlinde, Dimovski, Aleksandar, Brieghel, Christian, Lawless, Sarah, Meggendorfer, Manja, Brazdilova, Kamila, Ritgen, Matthias, Facco, Monica, Tresoldi, Cristina, Visentin, Andrea, Patriarca, Andrea, Catherwood, Mark, Bonello, Lisa, Sudarikov, Andrey, Vanura, Katrina, Roumelioti, Maria, Skuhrova Francova, Hana, Moysiadis, Theodoros, Veronese, Silvio, Giannopoulos, Krzysztof, Mansouri, Larry, Karan-Djurasevic, Teodora, Sandaltzopoulos, Raphael, Bödör, Csaba, Fais, Franco, Kater, Arnon, Panovska, Irina, Rossi, Davide, Alshemmari, Salem, Panagiotidis, Panagiotis, Costeas, Paul, Espinet, Blanca, Antic, Darko, Foroni, Letizia, Montillo, Marco, Trentin, Livio, Stavroyianni, Niki, Gaidano, Gianluca, Francia di Celle, Paola, Niemann, Carsten, Campo, Elias, Anagnostopoulos, Achilles, Pott, Christiane, Fischer, Kirsten, Hallek, Michael, Oscier, David, Stilgenbauer, Stephan, Haferlach, Claudia, Jelinek, Diane, Chiorazzi, Nicholas, Pospisilova, Sarka, Lefranc, Marie-Paule, Kossida, Sofia, Langerak, Anton W., Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, Stamatopoulos, Kostas

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Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data von Baliakas, Panagiotis, Iskas, Michalis, Gardiner, Anne, Davis, Zadie, Plevova, Karla, Nguyen‐Khac, Florence, Malcikova, Jitka, Anagnostopoulos, Achilles, Glide, Sharron, Mould, Sarah, Stepanovska, Kristina, Brejcha, Martin, Belessi, Chrysoula, Davi, Frederic, Pospisilova, Sarka, Athanasiadou, Anastasia, Stamatopoulos, Kostas, Oscier, David

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Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia von Baliakas, Panagiotis, Moysiadis, Theodoros, Hadzidimitriou, Anastasia, Xochelli, Aliki, Jeromin, Sabine, Agathangelidis, Andreas, Mattsson, Mattias, Sutton, Lesley-Ann, Minga, Eva, Scarfò, Lydia, Rossi, Davide, Davis, Zadie, Villamor, Neus, Parker, Helen, Kotaskova, Jana, Stalika, Evangelia, Plevova, Karla, Mansouri, Larry, Cortese, Diego, Navarro, Alba, Delgado, Julio, Larrayoz, Marta, Young, Emma, Anagnostopoulos, Achilles, Smedby, Karin E, Juliusson, Gunnar, Sheehy, Oonagh, Catherwood, Mark, Strefford, Jonathan C, Stavroyianni, Niki, Belessi, Chrysoula, Pospisilova, Sarka, Oscier, David, Gaidano, Gianluca, Campo, Elias, Haferlach, Claudia, Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas

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Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia von Papakonstantinou, Nikos, Ntoufa, Stavroula, Tsagiopoulou, Maria, Moysiadis, Theodoros, Bhoi, Sujata, Malousi, Andigoni, Psomopoulos, Fotis, Mansouri, Larry, Laidou, Stamatia, Papazoglou, Despoina, Gounari, Maria, Pasentsis, Konstantinos, Plevova, Karla, Kuci‐Emruli, Venera, Duran‐Ferrer, Marti, Davis, Zadie, Ek, Sara, Rossi, Davide, Gaidano, Gianluca, Ritgen, Matthias, Oscier, David, Stavroyianni, Niki, Pospisilova, Sarka, Davi, Frederic, Ghia, Paolo, Hadzidimitriou, Anastasia, Belessi, Chrysoula, Martin‐Subero, Jose I, Pott, Christiane, Rosenquist, Richard, Stamatopoulos, Kostas

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