The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing von Hu, Xiaohui, Harvey, Samuel E., Zheng, Rong, Lyu, Jingyi, Grzeskowiak, Caitlin L., Powell, Emily, Piwnica-Worms, Helen, Scott, Kenneth L., Cheng, Chonghui

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Contribution of p53 to metastasis von Powell, Emily, Piwnica-Worms, David, Piwnica-Worms, Helen

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Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast von Sinha, Vidya C., Rinkenbaugh, Amanda L., Xu, Mingchu, Zhou, Xinhui, Zhang, Xiaomei, Jeter-Jones, Sabrina, Shao, Jiansu, Qi, Yuan, Zebala, John A., Maeda, Dean Y., McAllister, Florencia, Piwnica-Worms, Helen

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A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations von Reddy, Tejaswini P., Rosato, Roberto R., Li, Xiaoxian, Moulder, Stacy, Piwnica-Worms, Helen, Chang, Jenny C.

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Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation von Molkentine, Jessica M., Fujimoto, Tara N., Horvath, Thomas D., Grossberg, Aaron J., Garcia, Carolina J. Garcia, Deorukhkar, Amit, de la Cruz Bonilla, Marimar, Lin, Daniel, Samuel, Errol L. G., Chan, Wai Kin, Lorenzi, Philip L., Piwnica-Worms, Helen, Dantzer, Robert, Tour, James M., Mason, Kathryn A., Taniguchi, Cullen M.

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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 von Cha, Jong-Ho, Yang, Wen-Hao, Xia, Weiya, Wei, Yongkun, Chan, Li-Chuan, Lim, Seung-Oe, Li, Chia-Wei, Kim, Taewan, Chang, Shih-Shin, Lee, Heng-Huan, Hsu, Jennifer L., Wang, Hung-Ling, Kuo, Chu-Wei, Chang, Wei-Chao, Hadad, Sirwan, Purdie, Colin A., McCoy, Aaron M., Cai, Shirong, Tu, Yizheng, Litton, Jennifer K., Mittendorf, Elizabeth A., Moulder, Stacy L., Symmans, William F., Thompson, Alastair M., Piwnica-Worms, Helen, Chen, Chung-Hsuan, Khoo, Kay-Hooi, Hung, Mien-Chie

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics von Ma, Cynthia X, Janetka, James W, Piwnica-Worms, Helen

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ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1 von Zhao, H, Piwnica-Worms, H

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CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib von Sen, Triparna, Tong, Pan, Stewart, C Allison, Cristea, Sandra, Valliani, Aly, Shames, David S, Redwood, Abena B, Fan, You Hong, Li, Lerong, Glisson, Bonnie S, Minna, John D, Sage, Julien, Gibbons, Don L, Piwnica-Worms, Helen, Heymach, John V, Wang, Jing, Byers, Lauren Averett

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The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors von Redwood, Abena B., Zhang, Xiaomei, Seth, Sahil B., Ge, Zhongqi, Bindeman, Wendy E., Zhou, Xinhui, Sinha, Vidya C., Heffernan, Timothy P., Piwnica-Worms, Helen

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Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival von Tinkum, Kelsey L., Stemler, Kristina M., White, Lynn S., Loza, Andrew J., Jeter-Jones, Sabrina, Michalski, Basia M., Kuzmicki, Catherine, Pless, Robert, Stappenbeck, Thaddeus S., Piwnica-Worms, David, Piwnica-Worms, Helen

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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer von Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen

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Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers von Liu, Xuan, Ge, Zhongqi, Yang, Fei, Contreras, Alejandro, Lee, Sanghoon, White, Jason B., Lu, Yiling, Labrie, Marilyne, Arun, Banu K., Moulder, Stacy L., Mills, Gordon B., Piwnica-Worms, Helen, Litton, Jennifer K., Chang, Jeffrey T.

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Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence von Sinha, Vidya C., Piwnica-Worms, Helen

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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding von GRAVES, Paul R, LOVLY, Christine M, UY, Geoffrey L, PIWNICA-WORMS, Helen

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Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer von Jaggupilli, Appalaraju, Ly, Stanley, Nguyen, Khoa, Anand, Vivek, Yuan, Bin, El-Dana, Fouad, Yan, Yuanqing, Arvanitis, Zoe, Piyarathna, Danthasinghe Waduge Badrajee, Putluri, Nagireddy, Piwnica-Worms, Helen, Manning, Henry Charles, Andreeff, Michael, Battula, V. Lokesh

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Kinetics of Regulated Protein-Protein Interactions Revealed with Firefly Luciferase Complementation Imaging in Cells and Living Animals von Luker, Kathryn E., Matthew C. P. Smith, Luker, Gary D., Gammon, Seth T., Piwnica-Worms, Helen, Piwnica-Worms, David, Cantley, Lewis C.

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DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress von VAN LEUNG PINEDA, HUH, Jiwon, PIWNICA-WORMS, Helen

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints von Zhao, Hui, Watkins, Janis L, Piwnica-Worms, Helen

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Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer von Shah, Vrutant V., Duncan, Aundrietta D., Jiang, Shiming, Stratton, Sabrina A., Allton, Kendra L., Yam, Clinton, Jain, Abhinav, Krause, Patrick M., Lu, Yue, Cai, Shirong, Tu, Yizheng, Zhou, Xinhui, Zhang, Xiaomei, Jiang, Yan, Carroll, Christopher L., Kang, Zhijun, Liu, Bin, Shen, Jianjun, Gagea, Mihai, Manu, Sebastian M., Huo, Lei, Gilcrease, Michael, Powell, Reid T., Guo, Lei, Stephan, Clifford, Davies, Peter J., Parker-Thornburg, Jan, Lozano, Guillermina, Behringer, Richard R., Piwnica-Worms, Helen, Chang, Jeffrey T., Moulder, Stacy L., Barton, Michelle Craig

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