The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion von Richards, Alexsia L, Sollars, Patricia J, Pitts, Jared D, Stults, Austin M, Heldwein, Ekaterina E, Pickard, Gary E, Smith, Gregory A

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GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein von Clark, Margaret J., Miduturu, Chandra, Schmidt, Aaron G., Zhu, Xuling, Pitts, Jared D., Wang, Jinhua, Potisopon, Supanee, Zhang, Jianming, Wojciechowski, Amy, Hann Chu, Justin Jang, Gray, Nathanael S., Yang, Priscilla L.

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Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus von Pitts, Jared D., Li, Pi-Chun, de Wispelaere, Melissanne, Yang, Priscilla L.

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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells von Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P., Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P., Li, Li, Schultz, Brian E., Sakowicz, Roman, Smith, Bill J., Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y.

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Structure of anellovirus-like particles reveal a mechanism for immune evasion von Liou, Shu-hao, Boggavarapu, Rajendra, Cohen, Noah R., Zhang, Yue, Sharma, Ishwari, Zeheb, Lynn, Mukund Acharekar, Nidhi, Rodgers, Hillary D., Islam, Saadman, Pitts, Jared, Arze, Cesar, Swaminathan, Harish, Yozwiak, Nathan, Ong, Tuyen, Hajjar, Roger J., Chang, Yong, Swanson, Kurt A., Delagrave, Simon

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Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking von Pitts, Jared D, Klabis, Jenifer, Richards, Alexsia L, Smith, Gregory A, Heldwein, Ekaterina E

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Identification of Buffer Conditions for Optimal Thermostability and Solubility of Herpesviral Protein UL37 Using the Thermofluor Assay von Koenigsberg, Andrea L, Pitts, Jared D, Heldwein, Ekaterina E

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Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein von de Wispelaere, Melissanne, Lian, Wenlong, Potisopon, Supanee, Li, Pi-Chun, Jang, Jaebong, Ficarro, Scott B., Clark, Margaret J., Zhu, Xuling, Kaplan, Jenifer B., Pitts, Jared D., Wales, Thomas E., Wang, Jinhua, Engen, John R., Marto, Jarrod A., Gray, Nathanael S., Yang, Priscilla L.

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Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo von Li, Pi-Chun, Jang, Jaebong, Hsia, Chih-Yun, Groomes, Patrice V, Lian, Wenlong, de Wispelaere, Melissanne, Pitts, Jared D, Wang, Jinhua, Kwiatkowski, Nicholas, Gray, Nathanael S, Yang, Priscilla L

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Sialyltransferase regulates nervous system function in Drosophila von Repnikova, Elena, Koles, Kate, Nakamura, Michiko, Pitts, Jared, Li, Haiwen, Ambavane, Apoorva, Zoran, Mark J, Panin, Vladislav M

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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice von Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.

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Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants von Pitts, Jared, Li, Jiani, Perry, Jason K, Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P, Mo, Hongmei, Maiorova, Evguenia, Bilello, John P

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Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in t... von Mackman, Richard L, Hui, Hon C, Perron, Michel, Murakami, Eisuke, Palmiotti, Christopher, Lee, Gary, Stray, Kirsten, Zhang, Lijun, Goyal, Bindu, Chun, Kwon, Byun, Daniel, Siegel, Dustin, Simonovich, Scott, Du Pont, Venice, Pitts, Jared, Babusis, Darius, Vijjapurapu, Arya, Lu, Xianghan, Kim, Cynthia, Zhao, Xiaofeng, Chan, Julie, Ma, Bin, Lye, Diane, Vandersteen, Adelle, Wortman, Sarah, Barrett, Kimberly T, Toteva, Maria, Jordan, Robert, Subramanian, Raju, Bilello, John P, Cihlar, Tomas

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Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys von Mackman, Richard L., Kalla, Rao V., Babusis, Darius, Pitts, Jared, Barrett, Kimberly T., Chun, Kwon, Du Pont, Venice, Rodriguez, Lauren, Moshiri, Jasmine, Xu, Yili, Lee, Michael, Lee, Gary, Bleier, Blake, Nguyen, Anh-Quan, O’Keefe, B. Michael, Ambrosi, Andrea, Cook, Meredith, Yu, Joy, Dempah, Kassibla Elodie, Bunyan, Elaine, Riola, Nicholas C., Lu, Xianghan, Liu, Renmeng, Davie, Ashley, Hsiang, Tien-Ying, Dearing, Justin, Vermillion, Meghan, Gale, Michael, Niedziela-Majka, Anita, Feng, Joy Y., Hedskog, Charlotte, Bilello, John P., Subramanian, Raju, Cihlar, Tomas

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Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses von Gordon, Calvin J., Walker, Simon M., Tchesnokov, Egor P., Kocincova, Dana, Pitts, Jared, Siegel, Dustin S., Perry, Jason K., Feng, Joy Y., Bilello, John P., Götte, Matthias

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Identification of small molecule inhibitors targeting the Zika virus envelope protein von Pitts, Jared, Hsia, Chih-Yun, Lian, Wenlong, Wang, Jinhua, Pfeil, Marc-Philipp, Kwiatkowski, Nicholas, Li, Zhengnian, Jang, Jaebong, Gray, Nathanael S., Yang, Priscilla L.

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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection von Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.

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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys von Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.

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539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir von Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P

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BACULOVIRUS EXPRESSION SYSTEMS von PITTS, Jared, David, DELAGRAVE, Simon

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