Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index von Pissarnitski, Dmitri A, Kekec, Ahmet, Yan, Lin, Zhu, Yuping, Feng, Danqing D, Huo, Pei, Madsen-Duggan, Christina, Moyes, Christopher R, Nargund, Ravi P, Kelly, Terri, Zhang, Xiaoping, Carballo-Jane, Ester, Gorski, Judith, Zafian, Peter, Qatanani, Mo, Kaarsholm, Niels, Meng, Fanyu, Jia, Xiujuan, Lee, Keun-Joong, Wang, Weixun, Xu, Sherrie, Hohn, Michael J, Iammarino, Michael J, McCoy, Mark A, Okoh, Grace A, Liang, Yingkai, Hollingsworth, Scott A, Erion, Mark D, Kelley, David E, Garbaccio, Robert M, Zhang, Amy, Mu, James, Lin, Songnian

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Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors von Zhao, Zhiqiang, Pissarnitski, Dmitri A, Josien, Hubert B, Wu, Wen-Lian, Xu, Ruo, Li, Hongmei, Clader, John W, Burnett, Duane A, Terracina, Giuseppe, Hyde, Lynn, Lee, Julie, Song, Lixin, Zhang, Lili, Parker, Eric M

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Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors von Zhao, Zhiqiang, Pissarnitski, Dmitri A., Josien, Hubert B., Bara, Thomas A., Clader, John W., Li, Hongmei, McBriar, Mark D., Rajagopalan, Murali, Xu, Ruo, Terracina, Giuseppe, Hyde, Lynn, Song, Lixin, Zhang, Lili, Parker, Eric M., Osterman, Rebecca, Buevich, Alexei V.

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors von Pissarnitski, Dmitri A., Zhao, Zhiqiang, Cole, David, Wu, Wen-Lian, Domalski, Martin, Clader, John W., Scapin, Giovanna, Voigt, Johannes, Soriano, Aileen, Kelly, Theresa, Powles, Mary Ann, Yao, Zuliang, Burnett, Duane A.

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Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo von Sun, Zhong-Yue, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane, Chu, Inhou, Clader, John, Cohen-Williams, Mary, Cole, David, Czarniecki, Michael, Durkin, James, Gallo, Gioconda, Greenlee, William, Josien, Hubert, Huang, Xianhai, Hyde, Lynn, Jones, Nicholas, Kazakevich, Irina, Li, Hongmei, Liu, Xiaoxiang, Lee, Julie, MacCoss, Malcolm, Mandal, Mihir B, McCracken, Troy, Nomeir, Amin, Mazzola, Robert, Palani, Anandan, Parker, Eric M, Pissarnitski, Dmitri A, Qin, Jun, Song, Lixin, Terracina, Giuseppe, Vicarel, Monica, Voigt, Johannes, Xu, Ruo, Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang, Zhu, Xiaohong, Zhu, Zhaoning

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Discovery of a Tetrahydrobenzisoxazole Series of γ‑Secretase Modulators von Zhao, Zhiqiang, Pissarnitski, Dmitri A, Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J, Hyde, Lynn A, Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M

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Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors von McBriar, Mark D., Clader, John W., Chu, Inhou, Del Vecchio, Robert A., Favreau, Leonard, Greenlee, William J., Hyde, Lynn A., Nomeir, Amin A., Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Zhang, Lili, Zhao, Zhiqiang

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Tetrahydroquinoline sulfonamides as γ-secretase inhibitors von Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Zhang, Lili, Zhao, Zhiqiang

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Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors von Li, Hongmei, Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Josien, Hubert B., McBriar, Mark D., Nomeir, Amin, Pissarnitski, Dmitri A., Rajagopalan, Murali, Xu, Ruo, Zhao, Zhiqiang, Song, Lixin, Zhang, Lili

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors von Pissarnitski, Dmitri A., Asberom, Theodros, Bara, Thomas A., Buevich, Alex V., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, McEwan, Michael, McKittrick, Brian A., Nechuta, Terry L., Parker, Eric M., Sinning, Lisa, Smith, Elizabeth M., Song, Lixin, Vaccaro, Henry A., Voigt, Johannes H., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang

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Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors von Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Asberom, Theodros, Clader, John W., Favreau, Leonard, Greenlee, William J., Hyde, Lynn A., Nomeir, Amin A., Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Wong, Gwendolyn T., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang

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Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease von Asberom, Theodros, Zhao, Zhiqiang, Bara, Thomas A., Clader, John W., Greenlee, William J., Hyde, Lynn A., Josien, Hubert B., Li, Wei, McPhail, Andrew T., Nomeir, Amin A., Parker, Eric M., Rajagopalan, Murali, Song, Lixin, Wong, Gwendolyn T., Zhang, Lili, Zhang, Qi, Pissarnitski, Dmitri A.

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Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED von Boyle, Craig D., Xu, Ruo, Asberom, Theodros, Chackalamannil, Samuel, Clader, John W., Greenlee, William J., Guzik, Henry, Hu, Yuequing, Hu, Zhiyong, Lankin, Claire M., Pissarnitski, Dmitri A., Stamford, Andrew W., Wang, Yuguang, Skell, Jeffrey, Kurowski, Stanley, Vemulapalli, Subbarao, Palamanda, Jairam, Chintala, Madhu, Wu, Ping, Myers, Joyce, Wang, Peng

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SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction von PISSARNITSKI, Dmitri A, ASBEROM, Theodros, PALAMANDA, Jairam, STAMFORD, Andrew W, VEMULAPALLI, Subbarao, YUGUANG WANG, PENG WANG, PING WU, RUO XU, BOYLE, Craig D, CHACKALAMANNIL, Samuel, CHINTALA, Madhu, CLADER, John W, GREENLEE, William J, YUEQING HU, KUROWSKI, Stanley, MYERS, Joyce

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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects von Cohen-Williams, Mary E., Leach, Prescott T., Del Vecchio, Robert A., Zhang, Qi, Hyde, Lynn A., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

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Solution-Phase Parallel Synthesis of Carbamates as γ-Secretase Inhibitors von Vaccaro, Henry A, Zhao, Zhiqiang, Clader, John W, Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Pissarnitski, Dmitri A

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INSULIN RECEPTOR PARTIAL AGONISTS von FENG, Danqing, LIN, Songnian, PISSARNITSKI, Dmitri, A, HUO, Pei, KEKEC, Ahmet, YAN, Lin

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GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES von HUNTER, David, N, ZHU, Yuping, ZHAO, Zhiqiang, LIN, Songnian, PISSARNITSKI, Dmitri, A, HUO, Pei, MOYES, Christopher, R

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GLUCOSE-RESPONSIVE INSULIN CONJUGATES von ZHU, Yuping, FENG, Danqing, LIN, Songnian, PIPIK, Brenda, PISSARNITSKI, Dmitri, A, YAN, Lin

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INSULIN RECEPTOR PARTIAL AGONISTS von FENG, Danqing, LIN, Songnian, PISSARNITSKI, Dmitri, A, HUO, Pei, KEKEC, Ahmet, YAN, Lin

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