SU-F-J-187: The Statistical NTCP and TCP Models in the Proton Therapy von Jang, S, Frometa, T, Pyakuryal, A, Sio, T, Piseaux, R, Acosta, S, Ocana, K

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D21 IMMUNE PATHWAYS IN ACUTE LUNG INJURY AND FIBROSIS: Tissue Resident Alveolar Macrophages Are Lost During Influenza A Infection In Mice von Gonzalez, F, McQuattie-Pimentel, A, Soberanes, S, Casalino-Matsuda, M, Chi, M, Piseaux, R, Misharin, A V, Sporn, P H, Budinger, G S

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C37 PULMONARY FIBROSIS: Dexamethasone Therapy Does Not Prevent The Recruitment Of Monocyte-Derived Alveolar Macrophages During Lung Fibrosis von Gonzalez-Gonzalez, F J, Morales-Nebreda, L, McQuattie-Pimentel, A C, Piseaux, R, Chi, M, Radigan, K A, Jain, M, Misharin, A V, Perlman, H R, Budinger, G

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C103 OUTDOOR AIR POLLUTION: EPIDEMIOLOGY AND MECHANISMS: Metformin Inhibits Mitochondrial Ros Upstream Of Crac Channels In Alveolar Macrophages And Prevents Particulate Matter Air... von Soberanes, S, Misharin, A V, Jairaman, A, Chi, M, Chiarella, S E, Meliton, A, Anekalla, K Reddy, Gonzalez, F J, McQuattie-Pimentel, A, Piseaux, R, Perlman, H, Chandel, N S, Prakriya, M, Mutlu, G M, Budinger, G S

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D27 MACROPHAGES: RESOLVERS, RESPONDERS OR BOTH?: Tissue-Resident Alveolar Macrophages Persist Over The Lifespan With Minimal Input From The Bone Marrow But Are Replaced By Monocyte... von Mc Quattie-Pimentel, A C, Gonzalez, F J, Chen, C-I, Walter, J M, Chi, M, Soberanes, S, Piseaux, R, Ridge, K M, Perlman, H R, Budinger, G, Misharin, A V

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D96 DAMAGING EFFECTS OF INHALED PARTICULATES: Metformin Attenuates Particulate Matter Air Pollution Induced Thrombosis By Inhibiting Mitochondrial Ros Upstream Of Crac Channels In... von Soberanes, S, Jairaman, A, Chi, M, Meliton, A Y, Cho, J, Gonzalez-Gonzalez, F J, Mc Quattie-Pimentel, A C, Piseaux, R, Weinberg, S, Perlman, H R, Chandel, N S, Misharin, A V, Prakriya, M, Mutlu, G M, Budinger, G

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C67 ACUTE LUNG INJURY: Mitochondrial Catalase Enforced Expression (mcat-Ee) Transgenic Mice Are Protected Against Asbestos- And Bleomycin-Induced Lung Fibrosis In Part Via Benefici... von Cheresh, P, Kim, S-J, Jablonski, R P, Yeldandi, A, Nebreda, L Morales, Cheng, Y, Chi, M, Piseaux, R, Ridge, K M, Hart, C, Chandel, N S, Budinger, G, Kamp, D

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Impaired phagocytic function in CX3CR1+ tissue‐resident skeletal muscle macrophages prevents muscle recovery after influenza A virus‐induced pneumonia in old mice von Runyan, Constance E., Welch, Lynn C., Lecuona, Emilia, Shigemura, Masahiko, Amarelle, Luciano, Abdala‐Valencia, Hiam, Joshi, Nikita, Lu, Ziyan, Nam, Kiwon, Markov, Nikolay S., McQuattie‐Pimentel, Alexandra C., Piseaux‐Aillon, Raul, Politanska, Yuliya, Sichizya, Lango, Watanabe, Satoshi, Williams, Kinola J.N., Budinger, G. R. Scott, Sznajder, Jacob I., Misharin, Alexander V.

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Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis von Watanabe, Satoshi, Markov, Nikolay S., Lu, Ziyan, Aillon, Raul Piseaux, Soberanes, Saul, Runyan, Constance E., Ren, Ziyou, Grant, Rogan A., Maciel, Mariana, Abdala-Valencia, Hiam, Politanska, Yuliya, Nam, Kiwon, Sichizya, Lango, Kihshen, Hermon G., Joshi, Nikita, McQuattie-Pimentel, Alexandra C., Gruner, Katherine A., Jain, Manu, Sznajder, Jacob I., Morimoto, Richard I., Reyfman, Paul A., Gottardi, Cara J., Budinger, G. R. Scott, Misharin, Alexander V.

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Mitochondrial ubiquinol oxidation is necessary for tumour growth von Martínez-Reyes, Inmaculada, Cardona, Luzivette Robles, Kong, Hyewon, Vasan, Karthik, McElroy, Gregory S., Werner, Marie, Kihshen, Hermon, Reczek, Colleen R., Weinberg, Samuel E., Gao, Peng, Steinert, Elizabeth M., Piseaux, Raul, Budinger, G. R. Scott, Chandel, Navdeep S.

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A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages von Joshi, Nikita, Watanabe, Satoshi, Verma, Rohan, Jablonski, Renea P., Chen, Ching-I, Cheresh, Paul, Markov, Nikolay S., Reyfman, Paul A., McQuattie-Pimentel, Alexandra C., Sichizya, Lango, Lu, Ziyan, Piseaux-Aillon, Raul, Kirchenbuechler, David, Flozak, Annette S., Gottardi, Cara J., Cuda, Carla M., Perlman, Harris, Jain, Manu, Kamp, David W., Budinger, G. R. Scott, Misharin, Alexander V.

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The lung microenvironment shapes a dysfunctiona response of alveolar macrophages in aging von McQuattie-Pimentel, Alexandra C., Ren, Ziyou, Joshi, Nikita, Watanabe, Satoshi, Stoeger, Thomas, Chi, Monica, Lu, Ziyan, Sichizya, Lango, Aillon, Raul Piseaux, Chen, Ching, Soberanes, Saul, Chen, Zhangying, Reyfman, Paul A., Walter, James M., Anekalla, Kishore R., Davis, Jennifer M., Helmin, Kathryn A., Runyan, Constance E., Abdala-Valencia, Hiam, Nam, Kiwon, Meliton, Angelo Y., Winter, Deborah R., Morimoto, Richard, Mutlu, Gokhan M., Bharat, Ankit, Perlman, Harris, Gottardi, Cara J., Ridge, Karen M., Chandel, Navdeep S., Sznajder, Jacob, Balch, William E., Singer, Benjamin D., Misharin, Alexander, Budinger, G. R. Scott

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The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging von McQuattie-Pimentel, Alexandra C, Ren, Ziyou, Joshi, Nikita, Watanabe, Satoshi, Stoeger, Thomas, Chi, Monica, Lu, Ziyan, Sichizya, Lango, Aillon, Raul Piseaux, Chen, Ching-I, Soberanes, Saul, Chen, Zhangying, Reyfman, Paul A, Walter, James M, Anekalla, Kishore R, Davis, Jennifer M, Helmin, Kathryn A, Runyan, Constance E, Abdala-Valencia, Hiam, Nam, Kiwon, Meliton, Angelo Y, Winter, Deborah R, Morimoto, Richard I, Mutlu, Gökhan M, Bharat, Ankit, Perlman, Harris, Gottardi, Cara J, Ridge, Karen M, Chandel, Navdeep S, Sznajder, Jacob I, Balch, William E, Singer, Benjamin D, Misharin, Alexander V, Budinger, G R Scott

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Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage von Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Morales-Nebreda, Luisa, Cheng, Yuan, Hogan, Erin, Yeldandi, Anjana, Chi, Monica, Piseaux, Raul, Ridge, Karen, Michael Hart, C., Chandel, Navdeep, Scott Budinger, G.R., Kamp, David W.

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Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5 von Ghosh, Asish K., Soberanes, Saul, Lux, Elizabeth, Shang, Meng, Aillon, Raul Piseaux, Eren, Mesut, Budinger, G.R. Scott, Miyata, Toshio, Vaughan, Douglas E.

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A Genomic Approach To Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs during Multistrain Pneumonia von Agard, Mallory J, Ozer, Egon A, Morris, Andrew R, Piseaux, Raul, Hauser, Alan R

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Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration von Weng, Anthea, Maciel Herrerias, Mariana, Watanabe, Satoshi, Welch, Lynn C, Flozak, Annette S, Grant, Rogan A, Aillon, Raul Piseaux, Dada, Laura A, Han, Seung Hye, Hinchcliff, Monique, Misharin, Alexander V, Budinger, G R Scott, Gottardi, Cara J

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Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM 2.5 von Ghosh, Asish K, Soberanes, Saul, Lux, Elizabeth, Shang, Meng, Aillon, Raul Piseaux, Eren, Mesut, Budinger, G R Scott, Miyata, Toshio, Vaughan, Douglas E

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