Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9 von Batra, Ranjan, Nelles, David A., Pirie, Elaine, Blue, Steven M., Marina, Ryan J., Wang, Harrison, Chaim, Isaac A., Thomas, James D., Zhang, Nigel, Nguyen, Vu, Aigner, Stefan, Markmiller, Sebastian, Xia, Guangbin, Corbett, Kevin D., Swanson, Maurice S., Yeo, Gene W.

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Aberrant protein S -nitrosylation contributes to the pathophysiology of neurodegenerative diseases von Nakamura, Tomohiro, Prikhodko, Olga A, Pirie, Elaine, Nagar, Saumya, Akhtar, Mohd Waseem, Oh, Chang-Ki, McKercher, Scott R, Ambasudhan, Rajesh, Okamoto, Shu-ichi, Lipton, Stuart A

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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell von Knerr, Laurent, Prakash, Thazha P, Lee, Richard, Drury III, William J, Nikan, Mehran, Fu, Wuxia, Pirie, Elaine, Maria, Leonardo De, Valeur, Eric, Hayen, Ahlke, Ölwegård-Halvarsson, Maria, Broddefalk, Johan, Ämmälä, Carina, Østergaard, Michael E, Meuller, Johan, Sundström, Linda, Andersson, Patrik, Janzén, David, Jansson-Löfmark, Rasmus, Seth, Punit P, Andersson, Shalini

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Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS von Krach, Florian, Batra, Ranjan, Wheeler, Emily C., Vu, Anthony Q., Wang, Ruth, Hutt, Kasey, Rabin, Stuart J., Baughn, Michael W., Libby, Ryan T., Diaz-Garcia, Sandra, Stauffer, Jennifer, Pirie, Elaine, Saberi, Shahram, Rodriguez, Maria, Madrigal, Assael A., Kohl, Zacharias, Winner, Beate, Yeo, Gene W., Ravits, John

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forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity von Arnold, Carrie N, Pirie, Elaine, Dosenovic, Pia, McInerney, Gerald M, Xia, Yu, Wang, Nathaniel, Li, Xiaohong, Siggs, Owen M, Karlsson Hedestam, Gunilla B, Beutler, Bruce

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The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow von Siggs, Owen M, Arnold, Carrie N, Huber, Christoph, Pirie, Elaine, Xia, Yu, Lin, Pei, Nemazee, David, Beutler, Bruce

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Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained... von Pirie, Elaine, Ray, Shayoni, Pan, Calvin, Fu, Wuxia, Powers, Andrew F, Polikoff, Danielle, Miller, Colton M, Kudrna, Katrina M, Harris, Edward N, Lusis, Aldons J, Crooke, Rosanne M, Lee, Richard G

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Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide von Gurlo, Tatyana, Prakash, Thazha P, Wang, Zhongying, Archang, Maani, Pei, Lina, Rosenberger, Madeline, Pirie, Elaine, Lee, Richard G, Butler, Peter C

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Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice von Brandl, Katharina, Tomisato, Wataru, Li, Xiaohong, Neppl, Christina, Pirie, Elaine, Falk, Werner, Xia, Yu, Moresco, Eva Marie Y, Baccala, Roberto, Theofilopoulos, Argyrios N, Schnabl, Bernd, Beutler, Bruce

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mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα von Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

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S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD von Pirie, Elaine, Oh, Chang-ki, Zhang, Xu, Han, Xuemei, Cieplak, Piotr, Scott, Henry R., Deal, Amanda K., Ghatak, Swagata, Martinez, Fernando J., Yeo, Gene W., Yates, John R., Nakamura, Tomohiro, Lipton, Stuart A.

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Persistent Hyperalgesia in the Cisplatin-Treated Mouse as Defined by Threshold Measures, the Conditioned Place Preference Paradigm, and Changes in Dorsal Root Ganglia Activated Tra... von Park, Hue Jung, Stokes, Jennifer A., Pirie, Elaine, Skahen, James, Shtaerman, Yuri, Yaksh, Tony L.

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2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated... von FU, WUXIA, LEE, RICHARD, PIRIE, ELAINE C., PRAKASH, THAZHA, MURRAY, SUE, POWERS, ANDREW F., CROOKE, ROSANNE M.

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2066-P: Dyrk1a Antisense Oligonucleotides Conjugated to GLP-1R Agonist Promote Pancreatic Beta-Cell Proliferation von FU, WUXIA, LEE, RICHARD, PIRIE, ELAINE C., PRAKASH, THAZHA, MURRAY, SUE, POWERS, ANDREW, MULLICK, ADAM E., CROOKE, ROSANNE M.

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Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2′-O-Methoxyethyl Antisense Oli... von Pirie, Elaine, Cauntay, Patrick, Fu, Wuxia, Ray, Shayoni, Pan, Calvin, Lusis, Aldonis J., Hsiao, Jill, Burel, Sebastien A., Narayanan, Padma, Crooke, Rosanne M., Lee, Richard G.

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Modeling IBD in the mouse through random germline mutagenesis: P-173 von Brandl, Katharina, Tomisato, Wataru, Neppl, Christina, Pirie, Elaine, Schnabl, Bernd, Beutler, Bruce

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Modeling IBD in the mouse through random germline mutagenesis von Brandl, Katharina, Tomisato, Wataru, Neppl, Christina, Pirie, Elaine, Schnabl, Bernd, Beutler, Bruce

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A mutation of Ikbkg causes immune deficiency without impairing degradation of IkB[alpha] von Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Hedestam, Gunilla B Karlsson, Nemazee, David, Beutler, Bruce

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A Mutation of Ikbkg Causes Immune Deficiency without Impairing Degradation of lkBα von Siggs, Owen M., Berger, Michael, Krebs, Philippe, Arnold, Carrie N., Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G., Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Hedestam, Gunilla B. Karlsson, Nemazee, David, Beutler, Bruce

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mutation of Ikbkg causes immune deficiency without impairing degradation of IκBΠvon Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

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