Substrate interactions guide cyclase engineering and lasso peptide diversification von Barrett, Susanna E, Yin, Song, Jordan, Peter, Brunson, John K, Gordon-Nunez, Jessica, Costa Machado da Cruz, Gabriella, Rosario, Christopher, Okada, Bethany K, Anderson, Kelsey, Pires, Thomas A, Wang, Ruoyang, Shukla, Diwakar, Burk, Mark J, Mitchell, Douglas A

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Setter, Jocelyn R, Hunter, Joshua H, Cochran, Julia H, Waight, Andrew B, Gordon, Kristine A, Toki, Brian E, Emmerton, Kim K, Zeng, Weiping, Stone, Ivan J, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C

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Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Lai, Holden W H, Leiske, Christopher I, Emmerton, Kim K, Waight, Andrew B, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C

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SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models von Mazahreh, Rebecca, Mason, Marsha L, Gosink, John J, Olson, Devra J, Thurman, Robert, Hale, Christopher, Westendorf, Lori, Pires, Thomas A, Leiske, Christopher I, Carlson, Markus, Nguyen, Liem T, Cochran, Julia H, Okeley, Nicole M, Yumul, Roma, Jin, Steven, Stone, Ivan J, Sahetya, Disha, Nesterova, Albina, Allred, Sean, Hensley, Kelly M, Hu, Rachael, Lawrence, Robert, Lewis, Timothy S, Sandall, Sharsti

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Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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Effects of Cationic Proteins on Gold Nanoparticle/Aptamer Assays von Pires, Thomas A, Narovec, Conor M, Whelan, Rebecca J

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Abstract PS10-08: Tucatinib potentiates the activity of the antibody-drug conjugate T-DM1 in preclinical models of HER2-positive breast cancer von Kulukian, Anita, Taylor, Janelle, Jain, Nishi, Olson, Devra, Zaval, Margo, Thurman, Robert, Hengel, Shawna, Farr, Lauren, Pires, Thomas, Peterson, Scott R.

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Abstract A097: Tubulysin ADC payloads: An antimitotic drug class that retains activity in multidrug resistant models von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Emmerton, Kim K, Senter, Peter D, Jeffrey, Scott C

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Rebalanceamento Endógeno para Portfólios de Variância Mínima von Demos, Guilherme, Pires, Thomas, Moura, Guilherme Valle

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract von Gendreau, Ségolène, Porcher, Raphael, Thoreau, Benjamin, Paule, Romain, Maurier, François, Goulenok, Tiphaine, Frumholtz, Laure, Bernigaud, Charlotte, Ingen-Housz-Oro, Saskia, Mekinian, Arsène, Audemard-Verger, Alexandra, Gaillet, Antoine, Perard, Laurent, Samson, Maxime, Sonneville, Romain, Arlet, Jean-Benoît, Mirouse, Adrien, Kahn, Jean-Emmanuel, Charpentier, Julien, Hachulla, Éric, Hummel, Aurélie, Pires, Thomas, Carron, Pierre-Louis, Durel, Cécile-Audrey, Jourde, Wendy, Puechal, Xavier, Lega, Jean-Christophe, Sarrot-Reynauld, Françoise, Tieulie, Nathalie, Diot, Elisabeth, Guillevin, Loïc, Terrier, Benjamin

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Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021) von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity von Burke, Patrick J., Hamilton, Joseph Z., Pires, Thomas A., Leiske, Christopher I., Cochran, Julia H., Setter, Jocelyn R., Emmerton, Kim K., Waight, Andrew B., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract von Gendreau, Ségolène, Porcher, Raphael, Thoreau, Benjamin, Paule, Romain, Maurier, François, Goulenok, Tiphaine, Frumholtz, Laure, Bernigaud, Charlotte, Ingen-Housz-Oro, Saskia, Mekinian, Arsène, Audemard-Verger, Alexandra, Gaillet, Antoine, Perard, Laurent, Samson, Maxime, Sonneville, Romain, Arlet, Jean-Benoît, Mirouse, Adrien, Kahn, Jean-Emmanuel, Charpentier, Julien, Hachulla, Éric, Hummel, Aurélie, Pires, Thomas, Carron, Pierre-Louis, Durel, Cécile-Audrey, Jourde, Wendy, Puechal, Xavier, Lega, Jean-Christophe, Sarrot-Reynauld, Françoise, Tieulie, Nathalie, Diot, Elisabeth, Guillevin, Loïc, Terrier, Benjamin

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract von Gendreau, Ségolène, Porcher, Raphael, Thoreau, Benjamin, Paule, Romain, Maurier, François, Goulenok, Tiphaine, Frumholtz, Laure, Bernigaud, Charlotte, Ingen-Housz-Oro, Saskia, Mekinian, Arsène, Audemard-Verger, Alexandra, Gaillet, Antoine, Perard, Laurent, Samson, Maxime, Sonneville, Romain, Arlet, Jean-Benoît, Mirouse, Adrien, Kahn, Jean-Emmanuel, Charpentier, Julien, Hachulla, Éric, Hummel, Aurélie, Pires, Thomas, Carron, Pierre-Louis, Durel, Cécile-Audrey, Jourde, Wendy, Puechal, Xavier, Lega, Jean-Christophe, Sarrot-Reynauld, Françoise, Tieulie, Nathalie, Diot, Elisabeth, Guillevin, Loïc, Terrier, Benjamin

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Abstract 4075: Effect of PEG chain length on antibody-drug conjugate tumor and tissue distribution in tumor bearing xenograft mice von Chemuturi, Nagendra V., Anderson, Martha, Cochran, Julia, Pires, Thomas, Hunter, Josh, Meyer, David, Neale, Jason, Chin, Alice, Pittman, Paul, Balasubramanian, Cindy, Zapata, Francisco, Simmons, Jessica, Lyon, Robert, Alley, Steve

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Abstract 56: Antibody-drug conjugates containing glucuronide-tubulysin payloads display activity in MDR+ and heterogeneous tumor models von Burke, Patrick J., Hamilton, Joseph Z., Hunter, Joshua H., Cochran, Julia H., Pires, Thomas A., Leiske, Christopher I., Emmerton, Kim K., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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Abstract 2056: Development of quaternary amine linkers for ADCs: Application to auristatin E and tubulysin von Burke, Patrick J., Hamilton, Joseph Z., Pires, Thomas A., Setter, Jocelyn R., Hunter, Joshua H., Cochran, Julia H., Toki, Brian E., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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A Useful Synthetic Route to Yield Silver-Nanoparticles on Phyllosilicates and Morphologic Structural Investigations von Vilela Menegaz Teixeira Pires, Cléo Thomás Gabriel, Airoldi, Claudio, de Melo, Júlio César Perin

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A utilização do modelo de ultrapassagem (overshooting) dos preços das commodities como modelo de previsão da inflação futura von Boassi, Rinald, Seabra, Fernando, Pires, Thomas Henrique Schreurs, Meurer, Roberto

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Data from: Substrate interactions guide cyclase engineering and lasso peptide diversification von Barrett, Susanna, Yin, Song, Jordan, Peter, Brunson, John, Gordon-Nunez, Jessica, Costa Machado Da Cruz, Gabriella, Rosario, Christopher, Okada, Bethany, Anderson, Kelsey, Pires, Thomas, Wang, Ruoyang, Shukla, Diwakar, Burk, Mark, Mitchell, Douglas

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